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Attention please: Isotrexin is temporarily unavailable. Please follow this link to find information about acne treatments. What is Isotrexin? Isotrexin is a medicine that is used to treat acne. More information

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Read the package leaflet for more information about risks and side effects, or ask your doctor or pharmacist for advice.

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Product information
Attention please: Isotrexin is temporarily unavailable. Please follow this link to find information about acne treatments.

What is Isotrexin?

Isotrexin is a medicine that is used to treat acne. The gel contains two active ingredients:
  • Isotretinoin: a medicine that increases the turnover of the skin cells, which aids the natural exfoliation of the outer layers of skin and helps to unblock pores.
  • Erythromycin: an antibiotic that slows down the growth of bacteria and allows subcutaneous infections to heal.

Isotrexin is applied to the skin to treat acne and is only available on prescription.

What is Isotrexin used for?

Isotrexin is used to treat moderate to severe acne. It reduces the production of sebum and attacks the bacteria associated with acne. This helps to bring the inflammation of the sebaceous glands under control and allows pimples to heal while preventing the formation of new impurities. Isotrexin gives the skin a smooth and flawless appearance.

How to use Isotrexin

Isotrexin gel should be applied sparingly to clean, dry skin. Avoid getting the gel in contact with the eyes and other mucous membranes (e.g. linings of the nose). Do not apply to broken or burned areas of skin. Wash your hands thoroughly after applying the product. Wait until the medicine has been absorbed into your skin before using cosmetics or other products. It may take some time before beneficial effects on the skin can be seen. Continue using the gel until you achieve the type of result you desire.

Warning: This medicine makes the skin more sensitive to UV radiation. Avoid exposure to direct sunlight and sunbeds. Use sunscreen with a high SPF to prevent sunburn when outdoors.


Unless otherwise advised, the usual dose is:
  • Adults and children aged 12 and above: a thin layer applied to the affected areas, once or twice daily.

Consult a doctor if the symptoms have not improved after eight weeks. Isotrexin is not suitable for children under the age of 12. Read the package leaflet before use.

Side effects

Isotrexin gel may cause side effects, including:
  • Skin irritation (itching, burning, redness) or scaling of the skin at the application site.

If the side effects are severe, apply less of the gel or use it less often (e.g. every other day) until the irritation has settled. Consult a doctor if you experience other side effects. For more information on side effects, see the package leaflet.

When not to use Isotrexin

Isotrexin gel is not suitable for everyone and should not be used if:
  • You are allergic to isotretinoin, erythromycin or any other ingredient in this medicine;
  • You are pregnant, planning a pregnancy or breastfeeding.

Consult a doctor on the use of Isotrexin if you have or have a history of skin conditions such as skin cancer, rosacea or acne. Isotrexin is known to interact with some medicines. It is therefore important to tell the doctor what medicines you are already taking to make sure the combination is safe.

Pregnancy/driving ability/alcohol

This medicine should not be used by women who are pregnant or trying to conceive, because it may be harmful to a developing baby. It is not known if this medicine passes into breast milk after application to the skin. For this reason, it should not be used by women who are breastfeeding.

This medicine does not interact with alcohol or affect your ability to drive safely.
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