Avomine is a medication which uses the drug Promethazine - a sedating antihistamine available to be used for a range of reasons. This substance can treat or prevent feelings of sickness or nausea, and it is commonly recommended for people who experience these symptoms because of vertigo or travel. More information

A doctor will review your order and write you a prescription, if appropriate. This prescription is then forwarded to a pharmacy. The pharmacy will have your medicine delivered to you within one to three working days. Read more about this process here.

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Avomine is the brand name for a medication containing the active ingredient promethazine. This is a form of medication called an antihistamine which may reduce allergy symptoms. Avomine is also effective at reducing the receptors in the brain responsible for causing you to vomit. It can reduce feelings of nausea and sickness.  

What is Avomine? 

Avomine is a medication which uses the drug Promethazine - a sedating antihistamine available to be used for a range of reasons. This substance can treat or prevent feelings of sickness or nausea, and it is commonly recommended for people who experience these symptoms because of vertigo or travel. Avomine may also be used to relieve allergic reactions caused by hay fever and allergic skin rashes, but it can cause a sedative effect. It may sometimes be used to promote sleeping in adults with severe insomnia, but it is recommended that it should not be used for this reason for long term. 

When is Avomine used? 

Avomine is typically used to prevent vomiting and nausea related to conditions like motion sickness and vertigo. Some doctors will prescribe this medication to help people to stop being sick after surgery too. In some cases, you may be given Avomine to treat allergic symptoms like rash, running nose, and itching.  

For very short periods of time, it can be used to help certain pain relievers work better, or help you remain relaxed or get more sleep after surgery. In some cases, it has been used to help with the common cold and stop a runny nose. If you are not using Avomine for motion sickness, it may be dangerous to attempt to use it for other reasons. Avoid taking any medication without guidance and advice from a doctor or pharmacist.  

How do you use Avomine? 

Your doctor or pharmacist will be able to provide you with advice on how to use Avomine. You can also find instructions written on the printed leaflet inside your medication packet. This leaflet will contain a full list of the side effects common when taking Avomine. Make sure that you follow the instructions given by your doctor or pharmacist exactly. You may need to take multiple doses in a single day depending on your reasons for taking this medication.  

If you are using Avomine to prevent travel sickness, you will usually be asked to take the first dose at your bedtime on the night before you travel. You will also be able to take an additional dose on the day that you travel if necessary. Avomine can be taken before or after meals and should be swallowed with a drink of water. If given in liquid form for a child, it is important to follow the instructions for dosing on the bottle very carefully. The majority of people will only need to take Avomine for a short period of time when they are experiencing symptoms. You can stop taking Avomine after your symptoms abide unless your doctor suggests otherwise.  

Avomine should not be taken for more than a couple of days to help with sleeping or relaxation problems as it may lead to addiction and other negative side effects.  

What dosages are available? 

The dose of Avomine you will need to take will usually be advised by your doctor, or you can seek advice from your pharmacist. If you are taking this medication for flight sickness, then a 25mg tablet will usually be the most common dosage, taken once on the night before travel, and once on the morning of the travel.  

If you are taking Avomine for other purposes, such as to prevent sickness after surgery, or to overcome symptoms of hay fever, then you may need to take your medication more regularly. Patients taking Avomine for reasons other than motion sickness should ask their doctor for advice on how to manage their dosage. No more than one tablet should be taken every eight hours. It is important not to take Avomine for extended periods of time.  

What are the side effects of Avomine? 

Like any medication, Avomine can cause some side effects. If you notice any unusual symptoms occurring after you take Avomine, stop taking the medication and tell your doctor. Constipation, drowsiness, dizziness, dry mouth, blurred vision and some other issues may occur. If you have dry mouth frequently but want to continue taking Avomine, you could try chewing sugarless gum, or sucking on ice chips.  

If you notice the presence of more serious side effects when taking Avomine, such as fainting, a sudden change in your mood or state of mind, or a slowing heartbeat, tell your doctor immediately. Other severe side effects might include uncontrolled or unusual movement, tongue movements, shaking or tremors, easy bruising or bleeding, and difficulty urinating. Keep an eye out for signs of infection such as a persistent sore throat or fever too. If you experience severe stomach or abdominal pain, yellowing eyes or skin, or persistent vomiting when using Avomine, tell a doctor straight away. Get medical help immediately if you experience seizures or shallow, slow breathing.  

In very rare conditions, it's possible to experiencer neuroleptic malignant syndrome when taking Avomine. Get medical help immediately if you have muscle pain, weakness, stiffness, or tenderness, a sever fever, confusion, excessive sweating, tiredness, fast or irregular heartbeat, or signs of kidney problems (dark or frequent urine). Severe allergic reactions to Avomine is rare, but tell your doctor if you notice a rash, itching, swelling of the tongue, throat or face, or trouble breathing.  

When shouldn't you use Avomine? 

Make sure you tell your doctor or pharmacist about any other medications that you are taking before you use Avomine. This should include prescribed medications, over the counter drugs, herbal remedies and supplements. Before using this medication, tell your pharmacist or doctor if you have a history of breathing problems, including sleep apnea and asthma.  

Avomine may not be suitable for you if you have immune or blood problems, high pressure in the eyes, heart disease, or high blood pressure. It may also be inappropriate for people with certain brain disorders, liver disease, intestine or stomach problems, overactive thyroids, or problems with urination, potentially caused by an enlarged prostate.  

If you feel dizzy or drowsy when using Avomine, do not drive or operate heavy machinery, and avoid alcoholic beverages that could make these conditions worse. Remember that Avomine may make it harder for you to sweat, which means it's more likely that you're more likely to experience heat stroke if you get overly warm. Avoid doing things to cause you to feel too hot such as working out. Get medical help if you have a fever that doesn't go away.  

Avomine may not be ideal for use during pregnancy. It is unknown whether this substance passes into breast milk, so discuss this with your doctor before using it. Most of the time it is not a good idea to use Avomine if you are pregnant unless advised by your doctor. Your doctor will usually be able to recommend an alternative anti histamine or a different solution to deal with your motion sickness.  

Does Avomine interact with any other medications? 

Avomine may interact with other medications, Before you start taking this substance, make sure that you speak to your doctor or pharmacist about any other medications you might be taking, including those you bought without a prescription. It is important to talk to your doctor before you begin using new medications with Avomine, to ensure that the combination of drugs is safe.  

Avomine is not suitable for anyone taking an antidepressant called a monoamine oxidase inhibitor, such as phenelzine, or isocarboxazid. If you have taken those medications in the last fourteen days, do not take Avomine. It is also not a good idea to take Avomine with other medications used to help you sleep, such as zopiclone, or sedating antihistamines like hydroxyzine, or chlorphenamine. Do not take Avomine when using alcoholic or using antipsychotic medications like chlorpromazine. Avoid using this medication with barbiturates like phenobarbital, or benzodiazepines like diazepam. Avomine is not suitable to use with heavy-duty painkillers like codeine or morphine.  

You may have an increased risk of side effects when using Avomine if you have it when you are taking other medications like hyoscine, antihistamines like brompheniramine, or ant sickness medications like meclizine. Avomine may cause more side effects when used with anticholinergic medications given for Parkinson's disease, or muscle relaxants. Antihistamines like Avomine can reduce the effects of the Meniere's disease medication betahistine, and the histamine given for leukemia.  

Where can you buy Avomine? 

Avomine is available to buy online or offline over the counter or with a prescription. Make sure that you speak to your doctor if you are using Avomine for any reason other than motion sickness. It is important to talk to your doctor before using this medication if you're already using any other drugs for any reason, as Avomine can interact with other medications.  

Can you get Avomine without a prescription?  

Avomine is available in some forms over the counter, however it is not a good idea to purchase this substance without speaking to a pharmacist or doctor first. You will need to discuss your condition with your doctor and any medications you might be taking alongside Avomine. Speaking about your condition with your doctor will help you to avoid any dangerous side effects or interactions with other drugs. 




Actavis UK Ltd, the Electronic Medicines Compendium, 2015, Manufacturer's PIL, Sominex tablets [Accessed June 21st 2019], Available on: http://www.medicines.org.uk/EMC/medicine/21226/XPIL/Sominex+Tablets/  

Manufacturer's PIL, Phenergan® 10 mg Tablets; Sanofi, The electronic Medicines Compendium. [Accessed June 21st 2019], Available on: http://www.medicines.org.uk/EMC/medicine/3891/PIL/Phenergan+10mg+Tablets/  

Sanofi, Promethazine Hydrochloride, Phenergan 25mg tablets, [Accessed June 21st 2019], Available on: https://www.medicines.org.uk/emc/product/5588/pil  

Assessed by:

Dr Imran Malik, General practitioner
Registration number: GMC: 4741365

Dr Imran Malik studied undergraduate medicine at King's College University in Central London and clinical studies at the prestigious King's College Hospital. He graduated with a MBBS degree in 2000 and went on to gain postgraduate memberships with the Royal Society of Medicine and also General Practice in 2006.