Buccastem tablets are a popular anti-sickness medication. These tablets contain the active ingredient prochlorperazine, which is a kind of phenothiazine. Each table of Buccastem contains around 3mg of prochlorperazine in most cases. More information

A doctor will review your order and write you a prescription, if appropriate. This prescription is then forwarded to a pharmacy. The pharmacy will have your medicine delivered to you within one to three working days. Read more about this process here.

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Patient Leaflet(s)

Buccastem is a commonly used anti-sickness medication containing the active ingredient prochlorperazine. The active ingredient in this medication helps to control feelings of sickness and nausea by blocking crucial receptors in the brain.  

What is Buccastem? 

Buccastem tablets are a popular anti-sickness medication. These tablets contain the active ingredient prochlorperazine, which is a kind of phenothiazine. Each table of Buccastem contains around 3mg of prochlorperazine in most cases.  

The active ingredient in Buccastem helps to reduce feelings of sickness and nausea by blocking the dopamine receptors in the vomiting centre of the brain. This prevents the vomiting centre from getting the messages from the body’s nerves that encourage vomiting and nausea. Buccastem can provide relief from a range of conditions that cause nausea. Buccastem is a prescription-only medication.  

When is Buccastem used? 

Buccastem is a type of phenothiazine, which can be prescribed for a range of unrelated reasons and conditions. Some people are given this medication because they have issues with dizziness and balance. Other people take Buccastem because of nausea and vomiting caused by travel. 

Buccastem has been occassionally prescribed for various other conditions too, including  agitation, restlessness, and more. This medication works by blocking the dopamine reactions in the brain which affects the nervous system. In some cases Buccastem can be purchased from certain pharmacies in the form of a dissolvable tablet. This medication can be helpful in relieving the sickness caused by migraines and severe headaches.  

Buccastem for migraines should only be used if those migraines have been diagnosed by a doctor. Buccastem will not relieve the migraine headache and other symptoms, but it will reduce the feelings of sickness that some people have when experiencing a migraine. In some cases, this medication may be used as part of a combination treatment for a condition.  

How do you use Buccastem? 

Before starting this treatment, it is important to read the information printed on the manufacturer’s label inside of your pack. If you have any questions, you’ll need to speak to a pharmacist or another medical expert. Your patient leaflet will provide you with more information about this medication and the side effects that are common when taking it.  

Take Buccastem exactly as you are told to do so by your consultant or doctor. If you have been given the standard Buccastem tablets with 5mg of the active ingredient prochlorperazine, then you will be able to take them normally, like any tablet, with a glass of water. Some people prefer to take this medication after meals to reduce potential feelings of nausea.  

If you have been given the 3mg buccal tablets for Buccastem, then the tablets will need to be taken in a different way. These tablets are designed to dissolve naturally in your mouth. You should not choose or swallow the medication, just place the tablet in your mouth between your gum and upper lip and leave it to dissolve naturally over the following hour. You should take this medication after meals.  

What dosages are there? 

You will be given a dosage of Buccastem based on your condition and your response to treatment. Adults and children over the age of 12 will usually be given one or two tablets to take twice a day, which can be placed underneath the upper lip. This medication is not suitable for those under the age of 12. You should not continue to use this medication for an extended period of time without the approval of a doctor.  

It is possible to take Buccastem up to three times per day. However, if you are prescribed a regular dose, it is usually a good idea to get into the habit of taking your medication at the same time each day to avoid missing doses accidentally. Buccastem can also be prescribed on an “as needed” basis.  

If you forget to take a dose of your medication, take it when you remember, unless you are close to the time to take your next dose. In that case, you can miss the dose out and continue with your regular medication as usual.  

What are the side effects of Buccastem? 

Most people will respond well to Buccastem and have no significant side effects. However, it’s worth noting that all medications can affect people in different ways. Just because a side effect is stated either in this guide or on a patient leaflet doesn’t mean that you will necessarily experience the side effect for yourself.  

The most common side effects of Buccastem include: 

  • Drowsiness or loss of balance; 
  • Dizziness and discomfort; 
  • Dry mouth; 
  • Problems with sleeping
  • Agitation or mood changes; 
  • Drop in blood pressure; 
  • Irritation in the mouth or gum; 
  • Skin rashes; 
  • High temperatures. 

If you notice high temperatures combined with a sudden reduction in consciousness levels, as well as sweating and a fast heartbeat, it’s important to seek immediate help from a medical expert. This is a rare response to Buccastem, but it is very dangerous. You should stop taking the medication immediately. 

In some circumstances, it is also possible for Buccastem to cause blood clots in the vein, particularly in the legs. These clots may travel through your blood vessels and into your lungs which could lead to difficulty breathing and pain in the chest. If you notice these issues, seek help from a medical professional. Other less likely side effects of Buccastem might include yellowing of the eyes and skin, and convulsions. You may also experience disturbances in the natural number of blood cells in your blood. Alternatively, you can also experience high blood prolactin, which increases the size of breasts and can also increase the production of breast milk. 

A severe allergic reaction to this medication is rare. However, you should seek immediate medical attention if you notice dizziness, trouble breathing or swelling around the lips, tongue, and mouth. Additionally, keep in mind that this medication can cause a sudden drop in blood pressure when you’re moving from a sitting to a standing position. This could mean that you feel dizzy when you get up too quickly. This isn’t necessarily dangerous but can be disorienting.  

When shouldn’t you use Buccastem? 

Buccastem will be an excellent treatment for sickness and other conditions for many people. However, some medicines are not suitable for people with specific conditions and medical histories. In some cases, it will only be possible to take this medication if you take additional care and get regular checkups from your doctor. 

When speaking to your consultant, make sure that you answer all of the questions that they ask carefully. Buccastem might not be suitable to use if you are breastfeeding or pregnant, and it could be dangerous to take if: 

  • You have a blood vessel disease or heart condition; 
  • You have kidney, liver or prostate problems; 
  • You have breathing problems; 
  • You have issues with your thyroid gland; 
  • You have epilepsy, depression, Parkinson’s disease, myasthenia gravis, or increased pressure in the eyes; 
  • You have ever had jaundice or yellowing in the whites of your eyes or your skin. 
  • You have a tumor on your adrenal gland. 

Do not take this medication if you have ever had an allergic reaction to the ingredients in it. Tell your consultant if you have other allergies, as Buccastem can include inactive ingredients that also lead to common problems. You should not use this medication if you are dehydrated due to severe vomiting, and it may be a good idea to get medical advice if you are taking this drug over the age of 60. You should not use Buccastem if you have dementia, as this medication could increase your risk of stroke.  

People with a higher risk of blood clots may also be required to avoid this medication. In some cases, you will be able to take Buccastem with regular checkups with your doctor.   

Does Buccastem interact with other medications? 

It is always important to ensure that your consultant or doctor is aware of any other medications that you may be taking before you begin a new treatment. Make sure that you inform your consultant of all prescription medications that you are using, as well as over-the-counter medications and herbal supplements. Additionally, check with an expert before you begin taking new medications in combination with Buccastem.  

Buccastem can be more likely to cause certain side effects when taken with some other medications. For instance, other medications that cause drowsiness, such as sedating antihistamines, sleeping tablets, opioid painkillers, tricylic antidepressants, benzodiazepines and others may increase your chances of drowsiness when taking Buccastem. Tell your consultant if you are using pills like diazepam, phenobarbital, phenelzine, or morphine.  

It is also possible that Buccastem could increase the effects of blood-pressure lowering medications. If you notice that you feel dizzy or lightheaded after taking Buccastem, then this could be a sign of an interaction. Buccastem can also be more likely to cause side effects like confusion, constipation, and dry mouth when you take it with anticholinergic medications for Parkinson’s, antihistamines, antipsychotic medications and other anti-sickness tablets. It is not recommended to take Buccastem with antispasmodic medications, medicines for urinary incontinence, muscle relaxants, or MAOI or tricylic antidepressants.  

In certain circumstances, there may be an increased risk of a reduction in the number of white blood cells in your blood if you take Buccastem with other medications that have similar side effects, such as co-trimoxazole, penicillamine, and sulfadiazine. There is also an increased risk of side effects when Buccastem is used with lithium.  

Your consultant will have a complete list of medications that may react with Buccastem. 

Where can you buy Buccastem? 

Buccastem is available to buy online after a consultation with one of our professionals. We can send a prescription to a pharmacy for you within 3 working days.  

Can I get Buccastem without a prescription? 

Buccastem is a prescription-only medication. You will need a consultation and a prescription before you begin using this medication.  


BNF Nice, online, 2019, “PROCHLORPERAZINE”, [Accessed 18th of December 2019], Available on: https://bnf.nice.org.uk/drug/prochlorperazine.html 

Drugs.com online, 2019, “BUCCASTEM 3MG BUCCAL TABLETS” [Accessed 18th of December 2019], Available on: https://www.drugs.com/uk/buccastem-3mg-buccal-tablets-leaflet.html 

Medicines.org, online, 2019, “Buccastem M”[Accessed 18th of December 2019], Available on: https://www.medicines.org.uk/emc/product/478/smpc 

Assessed by:

Dr Imran Malik, General practitioner
Registration number: GMC: 4741365

Dr Imran Malik studied undergraduate medicine at King's College University in Central London and clinical studies at the prestigious King's College Hospital. He graduated with a MBBS degree in 2000 and went on to gain postgraduate memberships with the Royal Society of Medicine and also General Practice in 2006.