Climagest is currently out of stock. In the category Hormone Replacement Therapy (HRT) you will find alternatives.



Climagest is a hormone replacement therapy (HRT) preparation. It contains two active ingredients: estradiol and norethisterone. These are forms of the main female sex hormones oestrogen and progesterone. More information

A doctor will review your order and write you a prescription, if appropriate. This prescription is then forwarded to a pharmacy. The pharmacy will have your medicine delivered to you within one to three working days. Read more about this process here.

Patient Leaflet(s)

Attention please: Climagest has been discontinued by the manufacturer. Please follow this link to find other medicines in the category Hormone Replacement Therapy.

What is Climagest?

Climagest is a hormone replacement therapy (HRT) preparation. It contains two active ingredients: estradiol and norethisterone. These are forms of the main female sex hormones oestrogen and progesterone. Women's ovaries gradually produce less and less oestrogen in the period up to menopause, and oestrogen blood levels decline as a result. Climagest replaces the falling hormone levels in the body and so helps reduce the distressing symptoms of menopause. Climagest is a prescription-only medicine.

What is Climagest used for?

Climagest tablets are used to relieve menopausal symptoms, including:

  • Hot flashes;
  • Night sweats;
  • Dryness of eyes, vagina and/or mouth);
  • Mood swings or depression;
  • Sleep problems (difficulty falling asleep or staying asleep);
  • Loss of libido, painful intercourse;
  • Decrease in bone mass and density (osteoporosis).

HRT is used as a supplement to replace the falling levels of oestrogen in the body in order to relieve the symptoms of menopause. Because oestrogen stimulates the growth of the womb lining, Climagest also contains a progestogen hormone (norethisterone) to oppose oestrogen's effect.

How to use Climagest

Climagest comes in strips of 28 tablets. The tablets taken in the first 16 days of each Climagest cycle contain only estradiol, while the tablets of a different colour that are taken in the last 12 days of each cycle contain both estradiol and norethisterone. Take your first tablet from the blister pack corresponding to the day of the week. Follow the direction of the arrows on the blister pack until all the tablets have been taken. The tablets should be taken at the same time each day with some water, and can be taken with or without food. Climagest tablets should be taken back to back without a tablet-free interval. If used for more than two years, its use should be reviewed by a doctor.


Unless otherwise advised by the doctor, the usual dose in adult women is:

  • one tablet once daily.

Do not exceed the recommended dose and read the package leaflet carefully before use.

Side effects

Climagest may cause side effects. The most commonly noted side effects include:

  • Headache;
  • Gastrointestinal symptoms;
  • Breakthrough bleeding;
  • Increase in vaginal discharge;
  • Breast tenderness or soreness;
  • Mood swings.

Most side effects will disappear with continued use. If your symptoms have not improved after several weeks, consult a doctor. Read the package leaflet before use. It is important to be aware that all women using HRT have a slightly increased risk of serious side effects such as cancer and thrombosis compared with women who don't use HRT. See the package leaflet for further information.

When not to use Climagest

Climagest is not suitable for everyone. Do not use this HRT preparation if:

  • You are allergic to estradiol, norethisterone or any other ingredient in this medicine;
  • You have a known or past history of thrombosis, liver disease, breast cancer or any other oestrogen-related cancer;
  • You have a severe kidney condition, blood disease, vaginal bleeding of unknown cause or an overgrowth of the lining of the womb (endometrial hyperplasia).

Consult a doctor on the use of Climagest if you have a health condition that is not listed above or are currently on medication.

Pregnancy/driving ability/alcohol

Climagest is usually given to women who are no longer in the fertile age bracket. Women who don't fall within this group and who are pregnant or breastfeeding should not use this medicine, unless the doctor advises otherwise. Warning: Climagest is not a contraceptive pill! This medicine does not interact with alcohol or affect your ability to drive safely.