Clinorette prescriptions are currently not available via our online consultation service. You can, however, request an online consultation for hormone replacement therapy (hrt).



Clinorette is a medicine that is used to provide relief from the symptoms of menopause. It is a hormone replacement therapy (HRT) preparation that is given as a supplement to replace the falling hormone levels in the body. More information

A doctor will review your order and write you a prescription, if appropriate. This prescription is then forwarded to a pharmacy. The pharmacy will have your medicine delivered to you within one to three working days. Read more about this process here.

Patient Leaflet(s)

What is Clinorette?

Clinorette is a medicine that is used to provide relief from the symptoms of menopause. It is a hormone replacement therapy (HRT) preparation that is given as a supplement to replace the falling hormone levels in the body. The active ingredients estradiol and norethisterone restore hormonal balance, which helps reduce symptoms in women going through menopause. Clinorette is a prescription-only medicine.

What is Clinorette used for?

As women age, hormone production in the body decreases. This can cause different types of pre- and post-menopausal symptoms, including:

  • Irregular periods;
  • Hot flushes;
  • Night sweats;
  • Dryness of eyes and/or mouth;
  • Anxiety;
  • Mood swings or depression;
  • Sleep problems;
  • Loss of libido;
  • Painful sex due to vaginal dryness;
  • Osteoporosis (decrease in bone mass and density).

Clinorette is used to treat women who have not had a hysterectomy. The oestrogen in Clinorette (in this case in the form of estradiol) helps reduce distressing menopausal symptoms. Clinorette also contains a progestogen hormone, norethisterone, which opposes oestrogen's effect on the womb lining to prevent the risk of serious side effects.

How to use Clinorette

Clinorette comes in blister packs of 28 tablets. The white tablets taken in the first 16 days of each Clinorette cycle contain only estradiol, while the pink tablets that are taken in the last 12 days of each cycle contain both estradiol and norethisterone. The tablets should be taken at the same time each day with some water, and can be taken with our without food. Clinorette tablets should be taken back to back without a tablet-free interval. During the fourth week of your cycle, you will have a monthly withdrawal bleed. If Clinorette is used for more than two years, its use should be reviewed by a doctor.


Unless otherwise instructed by your doctor, the usual dose in adult women is:

  • one tablet once daily.

Do not exceed the recommended dose and read the package leaflet carefully before use.

Side effects

HRT can cause side effects. The following are some of the side effects that are known to be associated with Clinorette:

  • Headache;
  • Nausea, stomach ache or other gastrointestinal symptoms;
  • Breakthrough bleeding (spotting);
  • Vaginal discharge;
  • Breast tenderness or soreness;
  • Mood swings.

Most side effects are temporary and mild. Consult a doctor if the side effects are severe or persistent. Read the package leaflet thoroughly before use. It is important to be aware that all women using HRT have a slightly increased risk of serious side effects such as breast cancer and thrombosis compared with women who don't use HRT. See the package leaflet for further information.

When not to use Clinorette

Clinorette is not suitable for everyone. Do not use this HRT preparation if:

  • You are allergic to estradiol, norethisterone or any other ingredient in this medicine;
  • You have a known or past history of thrombosis, liver disease, breast cancer or other hormone-related cancer;
  • You have vaginal bleeding of unknown cause or an overgrowth of the lining of the womb (endometrial hyperplasia);
  • You have a blood disease or kidney disorder.

Consult a doctor on the use of Clinorette if you have a health condition that is not listed above or are currently on medication.

Pregnancy/driving ability/alcohol

Do not use Clinorette if you are pregnant or breastfeeding, unless otherwise advised by your doctor. Warning: Clinorette is not a contraceptive pill! If you are still capable of becoming pregnant, you should use a contraceptive of some kind. This medicine does not interact with alcohol or affect your ability to drive safely.