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Co-fluampicil is a form of medication known as an antibiotic. This powerful substance contains two different kinds of penicillin-based antibiotics – ampicillin and flucloxacillin. More information

A doctor will review your order and write you a prescription, if appropriate. This prescription is then forwarded to a pharmacy. The pharmacy will have your medicine delivered to you within one to three working days. Read more about this process here.

Patient Leaflet(s)

Co-fluampicil is a medication that contains two different kinds of antibiotics in the penicillin family. The ingredients in Co-fluampicil are ampicillin and flucloxacillin. This medication is used for the treatment of bacterial infections, and it works to kill the bacteria that it is at the root cause of the infection.  

What is Co-fluampicil? 

Co-fluampicil is a form of medication known as an antibiotic. This powerful substance contains two different kinds of penicillin-based antibiotics – ampicillin and flucloxacillin. This medication works by interfering with the reproduction and growth of bacteria in the body. The substance stops the cell walls from building properly, which means that the bacteria can’t thrive.  

Together, the two active ingredients in Co-fluampicil damage the bonds that hold bacterial walls together, allowing holes to appear in the walls of the bacteria. The Flucloxacillin antibiotic is very different from other types of penicillin antibiotics. Usually, when bacteria becomes resistant to certain kinds of penicillin antibiotics, they produce an enzyme known as penicillinase. This enzyme makes penicillin ineffective by breaking it down. However, Flucloxacillin is not affected by this enzyme. Because of this, it’s possible to use this drug to treat infections caused by bacteria that are resistant to other kinds of penicillin medications.  

The combination of the two medications in Co-fluampicil makes for a very powerful broad-spectrum antibiotic that can kill a wide selection of bacteria.  

When is Co-fluampicil used? 

Co-fluampicil is not usually used as the first line of treatment for most infections. The combination of the two penicillin type antibiotics in this medication means that it is very strong. Additionally, this can increase the chances of you experience side effects when taking the medication. Co-fluampicil is usually reserved for the treatment of very severe infections that include staphylococci based bacteria.  

To ensure that your bacteria is causing an infection that is susceptible to this kind of medication, your doctor may request a tissue sample, a urine sample, or a blood test.  

How do you use Co-fluampicil? 

It is very important to follow the instructions provided by your doctor exactly when taking Co-fluampicil. As with other forms of antibiotics, it is important to complete the full course that has been given to you for this medication. Stopping an antibiotic before your course has finished can lead to some serious side effects and increase your risk of the infection coming back stronger and more resistant in the future.  

Before you begin using this medication, read through the manufacturer’s printed patient leaflet that comes with the substance. The leaflet will offer information on how to use Co-fluampicil, as well as providing guidance into the kind of side effects that you may experience. Make sure that you take Co-fluampicil exactly as you are guided to do so. You will be required to space your doses out evenly throughout the day to get the best results.  

Co-fluampicil is best taken about an hour before a meal. You will get more positive results from Co-fluampicil if there is no food in your stomach. Swallow the capsules given to you whole, and ensure that you do not break, chew, or open them. Some people will be able to swallow Co-fluampicil easier with a glass of water. If you forget to take a dose of Co-fluampicil, take it as soon as you remember. Do not take multiple doses at the same time if you forget to use one dose.  

What dosages are there? 

Various factors can affect the dosage of any medication that you are given. Your body weight, response to treatment, and the condition that you are trying to treat are all things that need to be considered. You will need to take Co-fluampicil exactly as you are told to do so. Usually, the average dose is a capsule taken four times per day. Make sure that you spread your doses out evenly throughout the course of the day. 

If you are given the liquid version of this medication, then your doctor will tell you how to measure it properly. If you have been given liquid medication for a child, read the instructions provided carefully. Remember that Co-fluampicil is best used for short periods of time. Do not take this medication for longer than necessary, and do not take more than your doctor suggests.  

What are the side effects of Co-fluampicil? 

It is possible for any medication to cause unintended side effects. This is because people can respond to medications in different ways depending on their background and body type. Medicines and their possible side effects often need to be monitored. It’s important to let your doctor know or seek medical attention if you notice any negative outcomes when taking Co-fluampicil.  

Crucially, prolonged treatment with various forms of antibiotics can sometimes cause overgrowths of other organisms that aren’t susceptible to the treatment of the antibiotic. This can lead to problems like thrush. Speak to your doctor if you are concerned that you may have developed an additional infection after taking this medication.  

Common side effects of taking Co-fluampicil might include: 

  • Feeling sick of vomiting; 
  • Painful or upset stomach
  • Diarrhea; 
  • Discomfort; 
  • Rashes or hives. 

Make sure that you tell your doctor immediately if you get diarrhea that is prolonged or severe. If you notice any mucus or blood in your diarrhea this could be a sign that you are suffering from a problem caused by a resistant bacteria in your gut. Do not take any medications designed to stop diarrhea if it is severe. Other less common side effects of Co-fluampicil might include: 

  • Allergic reactions – tell a doctor immediately if you notice any swelling around the lips, face, or tongue when taking this medication; 
  • Fever or trouble controlling your temperature; 
  • Inflammation of the large intestine causing severe pain and diarrhea; 
  • Yellowing of the eyes and skin otherwise known as jaundice; 
  • Inflammation of the liver causing abdominal pain and trouble urinating; 
  • Aching of the joints or muscles; 
  • Disturbance in the white blood cell count in your blood. 

If you notice other side effects that have not been mentioned here, you may need to seek guidance from a medical professional.  

When shouldn’t you use Co-fluampicil? 

Not everyone will be safe to take this medication. It is important to discuss your condition and medical background with your consultant before you begin using Co-fluampicil. You will be asked questions about your medical history and your current condition to determine whether this substance is safe for you to use. Make sure that you answer these questions carefully and truthfully.  

If you are breast-feeding or pregnant, make sure that your doctor or consultant knows this, so they can let you know whether it’s safe to take this medication. You may not be able to use Co-fluampicil if: 

  • You think you have glandular fever; 
  • You think you have kidney problems; 
  • You think you might have issues with your liver functioning; 
  • You have issues with allergic reactions caused by penicillin. 

Even if you don’t have an allergy to penicillin, it may be crucial to tell your consultant about any allergies that you do have. Sometimes this medication could include inactive ingredients that cause allergic responses. You may be able to take this medication, but require additional monitoring or a lower dose if you are over the age of 50.  

You may also need monitoring if you: 

  • Have signs of a severe underlying illness; 
  • Have problems with your kidneys or liver; 
  • Have a history of allergic reactions; 
  • Have chronic, or acute lymphoid leukaemia; 
  • Have a problem with glandular fever. 

Does Co-fluampicil interact with other medications? 

Before taking any new medication, make sure that your doctor or consultant is aware of any other substances that you might be using. Different medications can interact with Co-fluampicil and cause severe side effects. It is important that you tell your consultant about everything you are using, from prescription medications, to over-the-counter drugs, and herbal substances.  

You should be able to take basic over the counter painkillers with this medication without experiencing any negative side effects. Additionally, although some antibiotics can change the way that your contraceptive pill or hormonal birth control will work, that is not the case with Co-fluampicil. You should not need to use an additional method of contraception with your pill when using Co-fluampicil However you can speak to a doctor or pharmacist if you feel nervous.  

If you are taking the contraceptive pill and you experience a great deal of vomiting and diarrhea when taking this pill, or because of your illness, you may need to use additional forms of protection. In rare circumstances, Co-fluampicil may change the performance of blood clotting medications like warfarin. Because of this, your doctor may need to check your blood clotting processes when you’re using Co-fluampicil. Additionally, Co-fluampicil can sometimes reduce the way that medicines are removed from your body. For instance, if you are taking a substance like methotrexate, your doctor may need to check that you are not likely to experience any further side effects when taking this antibiotic.  

Where can you buy Co-fluampicil? 

You will need to see your doctor and be examined, if your doctor has suggested this antibiotic then you can proceed to an online consultation to enable the purchase of Co-fluampicil through one of our pharmacy partners with a prescription. You will need a consultation for this medication.  

Can I get Co-fluampicil without a prescription? 

Like most antibiotics, Co-fluampicil is not available to purchase at this time without a prescription. It is important to ensure that this medication is right for you.  


BNF. Nice, online, 2020, “CO-FLUAMPICIL”[Accessed 15th of January 2020], Available on:  

Co-fluampicil”[Accessed 15th of January 2020], Available on:, online, “ CO-FLUAMPICIL ORAL SUSPENSION 125 MG/125 MG IN 5 ML”  [Accessed 15th of January 2020], Available on:, online, 2020, “Co-fluampicil” [Accessed 15th of January 2020], Available on:  

Assessed by:

Dr Imran Malik, General practitioner
Registration number: GMC: 4741365

Dr Imran Malik studied undergraduate medicine at King's College University in Central London and clinical studies at the prestigious King's College Hospital. He graduated with a MBBS degree in 2000 and went on to gain postgraduate memberships with the Royal Society of Medicine and also General Practice in 2006.