Colofac is a branded version of the generic medication Mebeverine. Mebeverine is antispasmodic medication that reduces the spasms of the muscles in the intestines, relieving pain in the gut and reducing symptoms like cramps and bloating. More information

A doctor will review your order and write you a prescription, if appropriate. This prescription is then forwarded to a pharmacy. The pharmacy will have your medicine delivered to you within one to three working days. Read more about this process here.

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Colofac is a form antispasmodic medication which features the active ingredient Mebeverine. Antispasmodic drugs like this one can help to reduce the spasms that can happen within the muscles of the intestines, causing discomfort, stomach pain, and irritable bowel syndrome. Colofac works on the internal muscles in the intestines, causing them to relax and eliminating cramps and pain.  

What is Colofac? 

Colofac is a branded version of the generic medication Mebeverine. Mebeverine is antispasmodic medication that reduces the spasms of the muscles in the intestines, relieving pain in the gut and reducing symptoms like cramps and bloating. Sometimes, Colofac can help with issues like diarrhea and constipation too.  

Colofac is a form of prescription-only medication that is prescribed to people who have been diagnosed with conditions that cause discomfort because of cramping and muscular spasms in the internal walls of their intestines. In some cases, this medication may be given as part of a combination treatment for conditions that require multiple sources of medical help, such as IBS.  

Your consultant may consider offering a generic version of this medication if the Colofac brand is not available.  

When is Colofac used? 

Colofac is intended for use to relieve the problems with irritable bowel syndrome. IBS is a condition that affects a lot of different people of different ages around the world. Although it can be difficult to fully diagnose, IBS can cause a number of problematic symptoms, usually in the gut and stomach. Some people experience alternating diarrhea and constipation, whereas other people have issues with bloating and wind.  

Colofac can also be used to address other conditions that are caused by the spasms in the bowel, such as mucous colitis, chronic irritable colon, and spastic colitis. It may be prescribed to relieve some of the side effects of chronic constipation, or as part of a treatment for a long-term illness that causes diarrhea and constipation.  

Colofac is only intended for use in adults and children over the age of 10. However, in some cases, specialists may be able to prescribe this medication for younger children who suffer severely from intestinal spasms if no better treatment is available. If you suffer from IBS and that is why you are getting this medication, your doctor may also refer you to a specialist for guidance on how you can reduce the number of symptoms that you experience. 

Changing your diet so that you consumer fewer fatty foods and making sure that you get plenty of liquid and fiber into your meals is a good way to start. It’s also important to avoid stress and tension and exercise regularly when you can.  

How do you use Colofac? 

Colofac is generally given in pill or tablet form. Before you begin treatment with this medication, it is important to speak to a consultant for guidance on how you can use the substance safely. You will also benefit from reading the patient leaflet that comes included with this medication, as it will provide you with more information about Colofac and any of the side effects that may come with it. Ensure that you take Colofac exactly as you are told to do so on the label.  

If you have been given the tablet or capsule version of this medication, then you can take one capsule twice per day, once in the morning and once in the evening. It is a good idea to spread the capsules out as much as possible so you can balance your exposure to the medication throughout the day and allow it to have the maximum impact on your symptoms.  

When you take your Colofac pill, make sure that you do not chew, swallow or break the capsules or pills provided to you. Breaking the pills would spoil the coating which can have an impact on how the medication is gradually released into your body. If you forget to take a dose of Colofac according to the instructions provided by your consultant, then you can take the next dose when you remember, unless it is too close to your next dose.  

Do not take two doses of Colofac at the same time to make up for a tablet that you have forgotten to take, simply continue with your next dose as and when it is due. Make sure that you seek help if you have taken an excessive amount of Colofac by accident. 

What dosages are there? 

Colofac is available in multiple forms, including tablets, liquids and capsules. The tablet version of Colofac contains 125mg of Mebeverine, and can be taken three times per day, twenty minutes before a meal. You should swallow this tablet whole and make sure that you don’t take more than three tablets in a 24 hour period.  

If you are given the capsule version of the Colofac then it contains 200mg of modified release Mebeverine. Because the capsules are modified release, that means that they allow you to access the active ingredient more slowly – so that’s why they need to be swallowed whole. Swallowing the capsule whole will control how it is released into your body. Colofac capsules are usually prescribed at a dose of one tablet twice a day, once in the morning and once in the evening. If it helps, you can take these tablets 20 minutes before breakfast, and 20 minutes before your last meal of the day.  

Colofac is also available in a non-branded Mebeverine suspension or liquid. If you are given the liquid version of this medication, follow the instructions given by your consultant carefully, or check the instructions on the label. Shake the bottle before you measure the prescribed dose and use a measuring spoon or oral syringe to ensure that the dose is correct. Do not use a normal spoon with Colofac as this will not be accurate. You can take a dose of liquid three times each day, often twenty minutes before meals. 

What are the side effects of Colofac? 

All medications, including Colofac can sometimes cause side effects. If your consultant chooses to give you this medication, they will have assessed your capacity for side effects carefully before giving you the medication. It’s important to note that the side effects that can occur will be listed in your patient leaflet, however, different people respond to medications in different ways. You may find that you do not have any side effects when taking this substance, or that you have a response which hasn’t been listed by the manufacturer.  

Colofac is a very well-tolerated medication with very few side effects. This makes it a very common option for doctors to prescribe to people with IBS and other chronic conditions. In very rare cases, you may develop an allergic or itchy type rash around your face when you are using this medication, but that will not happen for most people. Other uncommon side effects may include slight feelings of nausea and dizziness, or headaches.  

An allergic reaction to this medication is rare. However, you should seek emergency medical attention if you notice any symptoms that indicate you may be having an allergic reaction. Allergies can cause swelling around the throat, lips and neck, as well as trouble breathing and dizziness. If you feel any uncomfortable responses in your body after taking Colofac and you are concerned, stop taking the medication and ask a doctor or pharmacist for further advice on what to do next.  

When shouldn’t you use Colofac? 

Colofac can cause negative reactions in some people more commonly than others. Because different people have different reactions to this medication, it’s important to be honest in your consultation before you begin taking this medication. Make sure that you answer any questions that your consultant has about your medical history and any conditions that you are currently treating or have been treating in the past.  

Sometimes it is only possible to take Colofac if you take extra care when using it. Your consultant will be able to give you more guidance if you provide an insight into your medical background. If you are pregnant or breastfeeding, you should only use this medication when it is recommended by a doctor. The safety of Colofac for pregnant and breastfeeding individuals has not been fully established at this time. For this reason, you will need to be extra careful.  

If you have severe constipation, or you know that something in your bowel is not working as it should be, then you should not take this medication. Additionally, it is important to tell your consultant if you have an allergies, including allergies to Mebeverine, the active ingredient of Colofac, or the non-active ingredients that are included within this medication.  

Does Colofac interact with other medications? 

Colofac and other medications may sometimes interact poorly with the drugs and substances that you are already using. It is important to tell your consultant about any medications that you are taking at the same time as Colofac to ensure that the combination is safe. This includes over-the-counter medications that you are using, and prescriptions given to you by your doctor. You should also make your consultant aware of any herbal supplements that you are using.  

Colofac doesn’t appear to have any dangerous interactions with any other medications at this time. However, as ongoing research into medication interactions continues, the information available may change. It is best to check with your consultant to be sure.  

Where can you buy Colofac? 

You can safely purchase Colofac online after a consultation with one of our professionals. If you are given this medication it will be sent to you to a local pharmacy for you to collect within three working days.  

Can I get Colofac without a prescription? 

Colofac and similar medications are not available without a prescription at this time. Please complete a consultation to access this medication.  


Medsafe, online, 2019, “Mebeverine hydrochloride tablets 135mg” [Accessed 18th of December 2019], Available on:, online, 2019, “Colofac 135 mg Tablets”, [Accessed 18th of December 2019], Available on:, 2019, online, “COLOFAC 135MG TABLETS” [Accessed 18th of December 2019], Available on: 

Assessed by:

Dr Imran Malik, General practitioner
Registration number: GMC: 4741365

Dr Imran Malik studied undergraduate medicine at King's College University in Central London and clinical studies at the prestigious King's College Hospital. He graduated with a MBBS degree in 2000 and went on to gain postgraduate memberships with the Royal Society of Medicine and also General Practice in 2006.