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Desmotabs (desmopressin)

Desmotabs a pill-based and prescription medication that contain the active ingredient Desmopressin. This is a form of vasopressin analogue, similar to the vasopressin naturally produced by your body. More information

A doctor will review your order and write you a prescription, if appropriate. This prescription is then forwarded to a pharmacy. The pharmacy will have your medicine delivered to you within one to three working days. Read more about this process here.

Patient Leaflet(s)

Desmotabs are a type of medication containing the active ingredient Desmopressin. This is a form of vasopressin analogue, which means that the medication is similar to a hormone that occurs naturally in the human body called vasopressin. Vasopressin may also be referred to as ADH.  

What is Desmotabs? 

Desmotabs a pill-based and prescription medication that contain the active ingredient Desmopressin. This is a form of vasopressin analogue, similar to the vasopressin naturally produced by your body. Antidiuretic hormone, or ADH, which is another name for vasopressin, is produced by the brain’s pituitary gland. The ADH in your body is responsible for controlling the natural balance of water levels in the body. Normally, the substance acts on the receptors in your kidney to prevent large amounts of water being passed out of the blood and into the urine.  

Desmopressin and ADH both help to prevent excessive amounts of urine. If the kidneys fail to concentrate the amount of urine in the body at night, this can cause bedwetting, or an increased need to go to the toilet frequently. Desmotabs use the active ingredient of desmopressin to bind to the ADH receptors in the kidneys, mimicking the effects of your natural ADH. This helps to reduce the urine production in your body. Desmotabs can be used to treat bedwetting during the night if the bedwetting is found to be caused by a deficiency of your natural hormones. 

A doctor will need to determine whether you need to continue taking this medication after a period of three months. You will need a trial period of at least one week without the medication to see if you can stop taking it.  

When is Desmotabs used? 

Desmotabs is most commonly prescribed to address conditions of Diabetes Insipidus. This is a condition when the body and kidneys are unable to control the balance of water in your body. Your kidneys may not be able to regulate how much water is passing out of your urine as well as they should. If you have cranial diabetes Inspidus, this may occur because your brain is releasing a reduced amount of ADH.  

Desmotabs works by having the same impact on your body and kidneys as ADH. The Desmotabs replaces the ADH that your body is lacking and helps to control the amount of urine that you have to manage at any given time. Sometimes this medication will be given to children who suffers regularly from problems with bedwetting too.  

In certain cases, your doctor or a consultant can prescribe Desmotabs when you have had surgery on the pituitary gland. Surgery on this glance can lead to an over-production of urine. Desmopressin medications are usually given for a short period of time after this surgery.  

Desmotabs can also be given to people with clotting deficiencies to help blood clot more effectively. Usually, for these cases, the medication will only be given for a very short period of time.  

If you suffer from diabetes insipidus it is very important that you are being monitored regularly and stopping the medication suddenly can be extremely dangerous. 

How do you use Desmotabs 

Before you begin treatment with any new medication, it is important to make sure that you understand the advice that has been provided to you by your consultant, or doctor. You will also need to read the manufacturer information that is provided within the printed patient leaflet in your medication. This leaflet is designed to give you more information about the substances that you have been given, and it will provide you with a full list of side effects that you may experience.  

Not all brands of Desmotabs are the same, so it’s important to follow the instructions that are provided with your supply of medication. Take this substance according to your consultant’s instructions. Usually, you will be given normal tablets that you can take at the same time each day with a glass of water. If you have been given tablets that melt in your mouth, you will need to place the tablet under your tongue and allow it to dissolve completely.  

If you are using the nasal solution for Desmpressin you will need to measure out the correct dose. If you are unsure, you can ask a nurse or pharmacist to show you how to measure the medication correctly. If you get the Desmopressin spray, make sure that you prime the spray before use.  

If you miss a dose of Desmotabs, or you forget to take one, take it as soon as you remember, unless it is almost time for your next dose.  

What dosages are there? 

Desmotabs come in the form of a 0.2mg tablet, usually in a package containing 30 tablets. The typical dose for most adults and children is one tablet taken every twenty four hours. You should not exceed the prescribed dose, as this can increase your chances of serious side effects. Additionally, it is important to avoid excessive fluid intake when you are using this medication, as it can lead up to an excessive built up of internal fluid. Make sure that you know how much water you should be drinking each day before you begin using Desmotabs.  

You can take this medication consistently for a period of up to three months, at which point your medication will need to be reviewed. You may need to increase your dose of this medication or try a different drug if the bed wetting behaviour hasn’t been rectified. 

If you experience any vomiting or diarrhea when taking this medication, you should stop taking it until you feel better. If you experience any symptoms or signs of water retention or a lower concentration of sodium in your blood stream, then you should see your doctor immediately. You may notice this issue because of a prolonged headache or feelings of nausea.  

What are the side effects of Desmotabs? 

Desmotabs are a relatively well-tolerated medication that is unlikely to cause any severe side effects. However, all medications can effect people in different ways. It’s worth reading through the side effects listed here and in your patient leaflet to ensure that you are aware of the different ways that this medication might affect you. Remember that just because a side effect is listed doesn’t mean that you will experience this issue.  

The most common side effects of Desmotabs will reduce naturally on their own as your body gets used to the medication. These include: 

Desmotabs needs to be taken with a restricted fluid intake. If you do not restrict your water intake when you are using this medication, then you might encounter side effects that include increased fluid retention, low blood sodium levels, and more. Rare side effects of Desmotabs can include seizures. 

An allergic reaction to this medication is rare, however, you should watch out for any potential signs that you are responding poorly to this medication. Allergic reactions can cause symptoms like swelling around the face and throat, trouble breathing and dizziness.  

When shouldn’t you use Desmotabs? 

Your consultant will have understood your symptoms and problems, they may have run some blood test to exclude other causes of excess urination such as diabetes mellitus and other such conditions. The consultant may advise demopressing after considering  if you: 

  • Have ever had a disease of the heart or blood vessels; 
  • Have any problems with the way that your kidneys function; 
  • Have ever had high blood pressure, epilepsy, asthma, cystic fibrosis, or migraines
  • Have ever had an addiction to alcohol or an alcohol problem
  • Have ever had an allergic reaction to medicines; 
  • Are breastfeeding or pregnant; 
  • Are using other medications that may interact with this medicine.  

Desmotabs can include inactive ingredients that may cause allergic reactions. Make sure that your consultant is aware of any allergies that you have before you begin using this medication.  

Does Desmotabs interact with other medications? 

It is important to tell your consultant what medicines you are already using before you begin taking Desmotabs, as this substance could interact negatively with certain substances. Ensure that your consultant is aware of all the medications that you are using, including over-the-counter drugs, prescription medications and herbal supplements. Similarly, check with a pharmacist or doctor before you begin using any new medications when you are taking Desmotabs as this will ensure that the combinations are safe.  

Some medications can increase the release of the hormone inside of the body, which could therefore increase the effects of Desmotabs. For instance, anti-inflammatory drugs like ibuprofen can have this effect, as can antidepressants with SSRIs, such as fluoxetine. Avoid using Desmotabs with antidepressants that are tricylic, like amityptline. Your doctor will check to make sure your medication is safe and does not interact with desmopressin before prescribing it. 

If you are taking Desmotabs with any medications that can increase the release of natural hormones in your body, this could increase your risk of dangerous side effects, like fluid retention.  

Where can you buy Desmotabs? 

Desmotabs is available to buy safely online and offline after either a doctor’s appointment or a consultation with a professional. We can give you a consultation and send a prescription if necessary to a collaborating pharmacy on your behalf. You will be able to collect your prescription from your pharmacy within three working days.  

Can I get Desmotabs without a prescription? 

Desmotabs is unsafe to take without a prescription. You should not use this medication until you’ve had a consultation to ensure that it is the right treatment for you.  

Sources, online, 2019, “Desmotabs 0.2mg” [Accessed 18th of December 2019], Available on:  

NICE, online, 2019, “Desmotabs 0.2mg - Summary of Product Characteristics (SmPC) - (eMC)”, [Accessed 18th of December 2019], Available on:, 2019, online, “DESMOTABS 0.2MG” [Accessed 18th of December 2019], Available on: 

Assessed by:

Dr Imran Malik, General practitioner
Registration number: GMC: 4741365

Dr Imran Malik studied undergraduate medicine at King's College University in Central London and clinical studies at the prestigious King's College Hospital. He graduated with a MBBS degree in 2000 and went on to gain postgraduate memberships with the Royal Society of Medicine and also General Practice in 2006.