Efracea (Oracea)

Efracea (Oracea)

Efracea and Oracea are both different names for a medicine called doxycycline which is a type of oral antibiotic.   Doxycycline belongs to the type of antibiotics called Tetracycline antibiotics which are broad-spectrum antibiotics, meaning they can be used to treat a wide variety of illnesses. More information

A doctor will review your order and write you a prescription, if appropriate. This prescription is then forwarded to a pharmacy. The pharmacy will have your medicine delivered to you within one to three working days. Read more about this process here.

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Rosacea is a skin condition that commonly occurs in 40 to 60-year-olds and though more usually found affecting women, when men do suffer it is often in a more severe form. Rosacea usually affects the forehead, cheeks nose and chin causing areas of redness, a bumpy complexion and the appearance of spots which can look a bit like acne and can also affect the eyes and eyelids causing swelling and pain. Rosacea can last for a long time and tends to be characterised by periods where it is quite severe and others where it is calmer. The cause of Rosacea is not really known, the immune system, the environment you live in and your genetics may all be linked to Rosacea. Treatments for Rosacea include topical creams and ointments, oral antibiotics and more extreme specialist treatments targeting specific areas and issues like laser treatment for dilated blood vessels. 

What is Efracea-Oracea? 

Efracea and Oracea are both different names for a medicine called doxycycline which is a type of oral antibiotic.  

Doxycycline belongs to the type of antibiotics called Tetracycline antibiotics which are broad-spectrum antibiotics, meaning they can be used to treat a wide variety of illnesses. 

Antibiotics work on bacterial infections by stopping the growth of bacteria or killing it by stopping it from making the proteins it needs to survive.  

Efracea and Oracea both contain 40mg of doxycycline and come in the form of a hard capsule. 

When is Efracea-Oracea used? 

Efracea and Oracea are used to treat Rosacea in adults. 

  • They target the pimples and red bumps on the skin in order to reduce them; 
  • They can also help to reduce redness and inflammation; 
  • Efracea/Oracea is an oral antibiotic so it treats the problem at the root cause, rather than a topical treatment that only treats the symptoms; 
  • By inhibiting the bacteria, Efracea/Oracea prevents it from growing and spreading and so lessens the symptoms of Rosacea. 

How do you use Efracea-Oracea? 

As with all medicines, you should follow the advice of your doctor or pharmacist when it comes to how to take them. Below is a general guide for Efracea/Oracea. 

  • Swallow the capsule whole, do not chew it; 
  • Take the capsule with a full glass of water to prevent throat and gut irritation; 
  • Take the capsule on an empty stomach, at least one hour before you eat anything and two hours after you have eaten anything; 
  • Do not have any products containing calcium within two to three hours of taking Efracea/Oracea as this can lessen the effectiveness of the treatment – avoid milk dairy products etc. during this time window. 

What dosages are there? 

Doses can vary according to the severity of your condition and what your doctor may deem a safe dose for you, always follow your doctor’s instructions when it comes to how much of your medicine to take and for how long. 

  • Each capsule contains 40mg of doxycycline; 
  • Take one capsule every morning; 
  • Continue to take the capsule daily until your doctor tells you to stop; 
  • Taking too much Efracea or Oracea can cause damage to your liver, kidneys or pancreas – if you do take too much seek immediate medical assistance; 
  • If you forget to take your capsule on time, take it as soon as you remember, but do not take a double dose to make up for a missed dose, just skip that dose if it is nearly time for your next one. 

What are the side effects of Efracea-Oracea? 

Just like all medication, Efracea and Oracea come with a risk of some side effects, not everyone who takes this medicine will experience side effects. If your side effects become difficult to live with or do not ease over time, seek help from your doctor as there may be other options. Often simply resting can be a good way to help your body cope with side effects until it gets used to the new drug. 

If you develop prolonged, severe or bloody diarrhoea when taking Efracea, seek immediate medical assistance as this could be a sign of bowel inflammation caused by taking antibiotics and can have serious consequences. 

Common side effects that may affect 1 to 100 in 1,000 people include: 

  • Fungal infection; 
  • Sinus headache; 
  • Diarrhoea; 
  • Back pain; 
  • Upper abdomen pain; 
  • General pain; 
  • Inflammation of the nose and throat; 
  • Inflammation of the sinuses; 
  • Anxiety; 
  • High or increased blood pressure; 
  • Dry mouth; 
  • Changes in the amount of glucose in your blood; 
  • Changes in liver function tests. 

Rare side effects that may affect 1 to 10 in 10,00 people include: 

  • Allergic reaction – seek immediate medical assistance if you think you are having an allergic reaction. Signs include: 
    • Swelling around the face, lips, eyes, mouth and throat; 
    • Breathing difficulties; 
    • Rapid heartbeat; 
    • Itching skin and hives. 
  • Nausea; 
  • Vomiting; 
  • Liver damage; 
  • Hives or rashes on the skin; 
  • Unusual skin reactions to sunlight; 
  • Increase pressure on the brain; 
  • Changes in the number of some blood cells; 
  • Increase the level of urea in the blood; 
  • Inflammation of the membrane surrounding the heart. 

Very rare side effects that may affect less than 1 in 10,00 people include: 

  • Damage to red blood cells; 
  • Difficulty swallowing; 
  • Inflammation of the tongue; 
  • Yeast infections around the genitals; 
  • Inflammation of the intestine; 
  • Inflammation of the skin leading to flaking; 
  • Discolouration of thyroid tissues; 
  • Inflammation of the oesophagus; 
  • Worsening of a condition called lupus which affects the immune system. 

When shouldn’t you use Efracea-Oracea? 

Do not take Efracea or Oracea if any of the following apply to you: 

  • If you are under the age of 12 (Efracea and Oracea can harm tooth development so children should not use it); 
  • If you are pregnant or breastfeeding  
  • If you are allergic to any type of medicine that is part of the tetracycline family, including doxycycline, or any of the other ingredients listed on the packet of this medicine; 
  • If you have had surgery to the upper part of your gut; 
  • If you have an absence of acid in your stomach caused by a condition called achlorhydria; 
  • If you are taking any other type of oral retinoid – a medicine used to treat skin disorders like severe acne. 

You should also take care with Efracea and Oracea if any of the following apply to you: 

  • You get colitis; 
  • You have liver disease; 
  • You suffer from irritation or ulcers in the oesophagus; 
  • You have a yeast infection or fungal infection; 
  • You have the type of Rosacea that affects the eyes; 
  • You have a muscle disease called myasthenia gravis; 
  • You spend a lot of time under strong sunlight or artificial sunlight as the risk of burning may be higher. 

Does Efracea-Oracea interact with other medications? 

Always tell your doctor and/or pharmacist about any other medication you are taking before starting a new course of treatment, this includes vitamins, supplements and herbal remedies. Some medicines can interact with each other causing more health problems and others can lessen the effectiveness of a particular treatment. 

With Efracea or Oracea you should take particular care with the following: 

  • Antacids, multi-vitamins and other products that contain calcium, aluminium, magnesium, iron, bismuth or cholestyramine – these medicines can reduce the effectiveness of Efracea so should only be taken 2-3 hours or more after you have taken Efracea or Oracea; 
  • Some treatments for ulcers and heartburn should also be taken at least 2 hours after taking Efracea or Oracea for the same reason; 

These are some examples of other medicines that interact badly with Efracea and Oracea include: 

  • Isotretinoin – used for acne; 
  • Barbiturates – sleeping pills or painkillers; 
  • Carbamazepine – used for epilepsy; 
  • Primidone – an anti-convulsant; 
  • Cyclosporin – used after organ transplants; 
  • Rifampicin – used for tuberculosis; 
  • General anaesthetic. 

Your doctor will check any other medication that you take before prescribing this 

Where can you buy Efracea-Oracea? 

You can buy Efracea and Oracea from any reputable pharmacy, choose the option that is easy for you. This is likely to be a long term medicine so you will probably need to purchase it more than once. It can be easier if you have a source you know you can trust and that you can access easily. 

Can I get Efracea-Oracea without a prescription? 

No, you cannot buy Efracea or Oracea without a prescription. It is an antibiotic medicine and as such is strictly controlled. Antibiotics only treat certain types of illness and you will need a consultation with a doctor to confirm the condition you have in order for them to prescribe this medicine for you.  

You will also need to have regular check-ups throughout your treatment to monitor how the medicine is working and to determine how long you need to continue the treatment.  

While antibiotics should not be taken indefinitely, you should always finish any course of antibiotic treatment prescribed for you as while your symptoms may have cleared up, the antibiotics will still be working on the root of the problem and killing off the bacteria or at least inhibiting it. If you stop your treatment early this may give the bacteria the chance to grow and spread again and lead to your symptoms returning. It may also then make it harder to get rid of them with a second round of antibiotic treatment and you could end up on medication for longer than would have been necessary. 


British Skin Foundation, n.d. Rosacea. British Skin Foundation. Retrieved 6 April 2020, from: <https://www.britishskinfoundation.org.uk/rosacea?gclid=EAIaIQobChMImLbxscDT6AIVWeDtCh3deQNREAAYASAAEgJJBvD_BwE>  

Newson, D., 2015. Rosacea And Rhinophyma. Rosacea Symptoms And Treatment. Patient.info. Retrieved 6 April 2020, from <https://patient.info/doctor/rosacea-and-rhinophyma

Galderma Laboratories, 2020. Treating Rosacea From The Inside Out. Oracea.com. Retrieved 6 April 2020, from: <https://www.oracea.com/

Galderma Laboratories, 2017. Medicines.org.uk. Retrieved 6 April 2020, from: <https://www.medicines.org.uk/emc/files/pil.6652.pdf

Assessed by:

Dr Imran Malik, General practitioner
Registration number: GMC: 4741365

Dr Imran Malik studied undergraduate medicine at King's College University in Central London and clinical studies at the prestigious King's College Hospital. He graduated with a MBBS degree in 2000 and went on to gain postgraduate memberships with the Royal Society of Medicine and also General Practice in 2006.