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Elleste Duet

Elleste Duet

Elleste Duet is a hormone replacement therapy (HRT) preparation for menopausal or post-menopausal women. Elleste Duet contains estradiol (an oestrogen hormone) and norethisterone (a progestogen hormone). More information

A doctor will review your order and write you a prescription, if appropriate. This prescription is then forwarded to a pharmacy. The pharmacy will have your medicine delivered to you within one to three working days. Read more about this process here.

Patient Leaflet(s)

What is Elleste Duet?

Elleste Duet is a hormone replacement therapy (HRT) preparation for menopausal or post-menopausal women. Elleste Duet contains estradiol (an oestrogen hormone) and norethisterone (a progestogen hormone). These ingredients supplement hormone deficiencies, which helps reduce menopausal symptoms. Elleste Duet is a prescription-only medicine.

What is Elleste Duet used for?

Women's ovaries gradually produce less and less oestrogen during menopause, and oestrogen blood levels decline as a result. The declining levels of oestrogen can cause distressing physical and psychological symptoms, such as:

  • Irregular periods;
  • Hot flashes;
  • Night sweats;
  • Dryness of mucous membranes (eyes, vagina and/or mouth);
  • Anxiety;
  • Mood swings;
  • Depression;
  • Insomnia;
  • Loss of libido;
  • Painful intercourse;
  • Osteoporosis (decrease in bone mass and density).

Elleste Duet reduces or, in some cases, totally eliminates these symptoms by restoring hormonal balance. Elleste Duet is usually used to treat women who have not had a hysterectomy.

How to use Elleste Duet

Elleste Duet is available in various strengths. A doctor should determine what strength you should use. This medicine comes in blister packs containing 28 tablets. You should start each cycle by taking a white (Elleste Duet 1 mg) or orange (Elleste Duet 2 mg) tablet. The tablets taken in the first 16 days of each cycle contain only estradiol, while the tablets of a different colour that are taken in the last 12 days of each cycle contain both estradiol and norethisterone. The tablets should be taken at the same time each day with some water. When you finish all 28, you should start with a new blister on the following day. Most women will have a monthly withdrawal bleed during the fourth week of their cycle.


Unless otherwise instructed by your doctor, the usual dose in adult women is:

  • one tablet once daily.

Do not exceed the recommended dose and read the package leaflet carefully before use.

Side effects

HRT can cause side effects. The most commonly reported side effects include:

  • Headache;
  • Gastrointestinal symptoms;
  • Breakthrough bleeding (spotting);
  • Vaginal discharge;
  • Breast tenderness or soreness;
  • Mood swings.

Most side effects are temporary and will disappear with continued use. Consult a doctor if the side effects are persistent. For a complete list of possible side effects, see the package leaflet. It is important to be aware that all women using HRT have a slightly increased risk of serious side effects such as breast cancer and thrombosis compared with women who don't use HRT. See the package leaflet for further information.

When not to use Elleste Duet

Elleste Duet is not suitable for everyone. Do not use this HRT preparation if:

  • You are allergic to estradiol, norethisterone or any other ingredient in this medicine;
  • You have a known or past history of thrombosis, liver disease, breast cancer or other hormone-related cancer;
  • You have vaginal bleeding of unknown cause or an overgrowth of the lining of the womb (endometrial hyperplasia);
  • You have a blood disease or kidney disorder.

Consult a doctor on the use of Elleste Duet if you have a health condition that is not listed above or are currently on medication.

Pregnancy/driving ability/alcohol

Do not use Elleste Duet if you are pregnant or breastfeeding, unless otherwise instructed by your doctor. Warning: ] Elleste Duet is not a contraceptive pill! If necessary you should use a contraceptive to avoid getting pregnant. This medicine does not interact with alcohol or affect your ability to drive safely.