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Evorel is the brand name for Estradiol which is a medicine that contains the female hormone oestrogen. The female body loses oestrogen during and after the menopause and this can cause unpleasant symptoms for women. More information

A doctor will review your order and write you a prescription, if appropriate. This prescription is then forwarded to a pharmacy. The pharmacy will have your medicine delivered to you within one to three working days. Read more about this process here.

Patient Leaflet(s)

Evorel is the brand name for Estradiol which is part of the HRT (hormone replacement therapy) group of medicines. Evorel is used by menopausal and post-menopausal women as a supplement for the female sex hormone oestrogen, which reduces after the menopause. The menopause is also sometimes referred to as ‘the change’.This hormone replacement therapy comes in the form of patches which are applied to the skin, below the waist. It is used as prescribed by a doctor.

What is Evorel? 

Evorel is the brand name for Estradiol which is a medicine that contains the female hormone oestrogen. The female body loses oestrogen during and after the menopause and this can cause unpleasant symptoms for women. Evorel can help relieve these symptoms and help improve a woman’s lifestyle. The menopause is the result of a woman aging and the hormone oestrogen declining. Some women go through the menopause with no symptoms whatsoever, but others experience unpleasant symptoms that they can sometimes find hard to deal with. Some of these symptoms include: 

  • Hot flushes 
  • Sweating 
  • Depression 
  • Loss of memory 
  • Vaginal dryness or itching 
  • Pain or discomfort during sex 
  • A general feeling of ‘not being oneself’ 

The menopause usually occurs in a woman’s late 40s to early 50s. It can take several years to complete, from the initial signs to the time when a woman is considered to have gone through the menopause. 

There are three stages to the menopause: 

  1. Peri-menopause: this is the pre-menopause stage when the first symptoms occur such as hot flushes and night sweats. A simple blood test can confirm if you are in the peri-menopause stage. This stage can last for 3-10 years and a woman is likely to continue to have periods during this time although they may be irregular.  
  2. Menopause: when a woman has her last period and continues to experience menopause symptoms. This process usually lasts for up to a year but can be shorter or longer. 
  3. Post-menopause: this is the stage a woman reaches when she has not had a period for a year. The symptoms of menopause can still occur for 2-5 years after this. 

Evorel works to replace the oestrogen a woman loses during the menopause and can be used at all stages to help cope with the symptoms.However, hormone replacement therapy is a short-term solution to assist the management of menopausal symptoms. It can be used for a period of years but should not be used indefinitely. If a woman is using HRT her doctor should review her annually and decide if the treatment should be continued. Evorel comes in four different patch variations: Evorel 25, Evorel 50, Evorel 75 and Evorel 100 and each contains a different amount of oestrogen, with Evorel 25 being the weakest with 25mg of oestrogen and Evorel 100 being the strongest with 100mg of oestrogen. It releases oestrogen into the bloodstream constantly. Your doctor will assess your individual situation when prescribing Evorel and decide which strength is best for you.

When is Evorel used? 

Evorel is used when a woman experiences menopause symptoms caused by a decline in oestrogen in her body. It is prescribed to alleviate these symptoms as it replaces the hormone oestrogen which the body gradually loses as a woman gets older.As a woman reaches middle age her body produces fewer of the two main hormones that are part of the female reproductive system: oestrogen and progestogen. These hormones control the menstrual cycle and a woman’s sexual development. In addition to producing less oestrogen a woman’s ovaries also produce fewer eggs as she ages. Evorel is also used to stop osteoporosis (weak and brittle bones) occurring after the menopause. Some women are susceptible to this condition as osteoporosis can be provoked by early menopause, smoking, taking some steroid medication, a family history of osteoporosis and in women who are small and slight-framed with small bones. It can also be used for women who have had a hysterectomy. A hysterectomy is when the uterus (womb) and sometimes the cervix, ovaries and fallopian tubes are surgically removed. A hysterectomy can prompt early menopause so Evorel can help treat the symptoms that may occur. There is a similar product to Evorel called Evorel Conti or Evorel Sequi which also contains the hormone progestogen which protects the lining of the womb. This is more suitable for women who have not had a hysterectomy as they will still have their womb. 

How do you use Evorel? 

Evorel is a skin patch that contains the hormone oestrogen. The patch contains an evenly balanced amount of the hormone and is applied to the lower part of the body (usually the upper thighs or hips). Evorel works as a slow-release medicine, gradually releasing oestrogen into the body through the skin. Evorel should not be applied to the upper body, particularly the arms or breasts. Many women find using Evorel patches convenient as they don´t have to remember to take a tablet or apply a cream every day. The patch is replaced every few days (usually twice a week) and should be used consistently to ensure an even flow of oestrogen into the body. It is important to follow the advice of your doctor as to which strength of Evorel to use and how often to change the patches. The patches come in different strengths: 25mg, 50mg, 75mg and 100mg. Each contains the corresponding amount of oestrogen. Your doctor should start you on the lowest suitable dose for you to allow your body to adjust to the HRT. The maximum safe dose of Evorel is 100mg per day, but you should only use this strength patch if advised by your doctor. Each patch should be applied in a different location on the body (below the waist) to avoid skin irritation. The patches should not be removed while bathing, showering or swimming. Strong heat and sunlight can speed up the release of the oestrogen in the patches. This is a slow-release medicine and works most effectively when the oestrogen hormone is released gradually. It is therefore advisable not to use a sauna or sunbed while using Evorel patches. You can sunbathe but you should keep the patch out of direct sunlight to prevent it getting hot and releasing a large dose of oestrogen into your body. Evorel is not a contraception medicine and will not prevent pregnancy. 

What dosages are there? 

There are four different dosages of Evorel: 25mg, 50mg, 75mg and 100mg. The dose you take should be as advised by your doctor. Only use one patch at a time and replace it twice a week. You should read the package leaflet before commencing with Evorel to check the contraindications and possible side effects.

What are the side effects of Evorel? 

As with all medicines, Evorel can cause some side effects. Side effects are more likely if you are using the larger 100mg patch. The possible side effects are: 

  • Breast pain 
  • Headaches 
  • Nausea  
  • Vaginal discharge 
  • Itchy skin (where you stick the patch, so be sure to apply it to a different area of your body each time you change the patch) 
  • Dizziness 
  • Depression 
  • Stomach problems 
  • Diarrhea 
  • An increase in weight 
  • Vaginal bleeding or spotting 
  • Joint pain 

If you experience any of these side effects, you should consult your doctor. There is some discussion that hormone replacement therapy can increase the risk of cancer. It is important you make a fully informed decision before taking Evorel so we advise you to talk to your doctor and read the package information leaflet.  

When shouldn’t you use Evorel? 

Evorel should not be given to children. It is a hormone replacement therapy for women of menopausal age. It is not prescribed for women of fertile age. Evorel is not suitable for women who are pregnant, trying to get pregnant or breastfeeding. Evorel is not recommended if you: 

  • Have had any cardiovascular problems 
  • Suffer from high blood pressure 
  • Have had a stroke 
  • Have had thrombosis or blood clots 
  • Suffer from intense migraines 

Be sure to tell your doctor of any previous illnesses you have had or any medication you are taking (including herbal medicines) before taking Evorel. 

Does Evorel interact with other medication? 

Evorel can interact with some medications. It is important to inform your doctor about any medicines you are taking before taking Evorel, including herbal medicines. If you have diabetes your doctor may decide to adjust the dose of your medication before giving your Evorel. It is important to monitor your blood sugar levels if you are diabetic and taking Evorel. There is a possibility that Evorel could affect how some medicines used to reduce blood pressure work. Whilst your blood pressure should be monitored regularly while taking hormone replacement therapy this is particularly important if you have high blood pressure and are taking medication for this. Evorel does not interact with any foods or alcohol. 

Where can you buy Evorel? 

You can purchase Evorel from a pharmacy with a prescription from a doctor. 

Can I get Evorel without a prescription? 

No, Evorel requires a prescription from a doctor and is not available over-the-counter.




Brazier, Y. (2017, May 25). What you need to know about HRT. Retrieved 28 April, 2019 from https://www.medicalnewstoday.com/articles/181726.php 

Evorel patches (estradiol). 11 June, 2015. Retrieved 28 April, 2019 from https://www.netdoctor.co.uk/medicines/a8239/evorel-patches-estradiol/ 

PACKAGE LEAFLET: INFORMATION FOR THE USER. Evorel l® Estradiol. (June 2014). Retrieved 29 April, 2019 from https://www.dokteronline.com/pils/en/patient_information_leaflet-3535-evorel-uk.pdf-1510756509.pdf 

Assessed by:

Dr Wouter Mol, General practitioner
Registration number: BIG: 9057675501

Dr Wouter Mol studied medicine at the University of Groningen. From 2002 to 2003, he served as a resident in neurology, and from 2003 to 2005 he served his residency training in internal medicine and emergency medicine. Wouter Mol has been working as a GP since 2005.