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Evorel Sequi

Evorel Sequi

Evorel Sequi is a hormone replacement therapy that comes as a transdermal patch. It contains two different female hormones, oestrogen in the form of estradiol and progesterone in the form of norethisterone. Estradiol is used by itself for the first two weeks of your menstrual cycle, then estradiol and norethisterone are used together for the last two weeks.  The reason both hormones are present is to prevent excessive thickening in the womb lining. 

The menopause is a time that is full of ups and downs for women, as your ovaries stop producing eggs, this causes fluctuations in the levels of the hormone oestrogen in your body which can lead to a whole host of side effects. Sometimes your periods will be normal, other times they’ll be lighter or heavier. 

Around 70% of women are affected by menopausal changes, although lifestyle and other medication may influence the symptoms they experience. Women can often benefit from lifestyle changes like exercising more, losing weight, stopping smoking and reducing alcohol intake and this alone will be enough for some women to control the symptoms. For other women, the symptoms are severe and even with lifestyle changes they still need extra help to live life to the full. 

Many women start to experience the symptoms of menopause when they are still having their periods, this is because the change can take several years to occur and it happens in stages  Hot flushes usually occur in the early stages of menopause and affect 60-85% of menopausal women. The severity of these can vary drastically. At their worst, they can cause a lot of distress, disturb sleep and interfere with work. On average the hot flushes last for 2 years but they can continue for more than 15. A hot flush usually lasts 3-5 minutes at a time and often there is a daily pattern. Taking a cold shower, wearing layers so you have something to remove, ensuring you wear cool cotton clothing and avoiding spicy foods, caffeine and alcohol can all help to minimise the disturbance you experience with hot flushes. 

Hot flushes can also go hand in hand with night sweats, palpitations, insomnia, joint aches and headaches, which can all occur early on in the menopause. Changes in your mood are another early symptom in the menopausal cycle. You may experience difficulty coping, become forgetful or excessively anxious, or simply feel that life is getting on top of you. If you are feeling low, find someone to talk to and don’t hesitate to seek medical assistance. Your sex life may also suffer if you experience vaginal dryness due to the low levels of oestrogen in your body, or simply lower libido. You may find that if you get help in the form of Hormone Replacement Therapy for your other symptoms, your libido will improve along with your mood. You can also get treatments specifically to help with vaginal dryness. 

Later in the menopause cycle, you may experience urine infections, or leaks, or the need to pee frequently and an increased likelihood of vaginal dryness, these symptoms are often under-reported as many women are embarrassed to discuss such issues, but real help is available for those who do. Other later symptoms include skin itching or a crawling sensation and thinning hair. All in all, your body has a lot to go through, so there is no shame in seeking medical help if after making lifestyle changes you are still unable to lead a full, active life. Symptoms of the menopause can last for many years so there is no sense in suffering through it. 

One of the many treatment options available to help with menopausal symptoms is Evorel Sequi, an HRT that comes as a transdermal patch. Read on to find out how it works. 

What is Evorel Sequi? 

Evorel Sequi is a hormone replacement therapy that comes as a transdermal patch. It contains two different female hormones, oestrogen in the form of estradiol and progesterone in the form of norethisterone. Estradiol is used by itself for the first two weeks of your menstrual cycle, then estradiol and norethisterone are used together for the last two weeks. 

The reason both hormones are present is to prevent excessive thickening in the womb lining. 

When is Evorel Sequi used? 

Evorel Sequi is used to treat menopausal symptoms. It can be used both during and after the menopause (as symptoms can continue for sometime after the menopause has finished). It can only be used by women who still have their womb. Evorel Sequi can also be used to prevent osteoporosis in some cases but it should not be the first line of treatment. 

How do you use Evorel Sequi? 

Evorel Sequi comes in what is known as a ’memory pack’, to help you remember when to use/remove the patches. Each pack contains four Evorel patches and four Evorel Conti patches. Always use Evorel Sequi as directed by your doctor. They will aim to give you the lowest dose of HRT for the shortest possible time to alleviate your symptoms. 

You only ever need to wear one patch at a time: 

  • Apply the patch below the waist (usually on the thigh or bottom)
  • Do not use on irritated or broken skin 
  • Do not place near the breast
  • Avoid putting any creams or products on the skin before trying to apply the patch
  • Don’t wear the patch in the same place twice in a row
  • Apply the patch to clean, dry, cool skin

To apply the patch:

  • Tear along the tow edges of the pouch using the notched as a guide 
  • Peel of half of the backing, don’t touch the sticky side
  • Apply the open half of the patch to your skin and press firmly 
  • Remove the remaining backing and press again to make sure the patch is firmly in place 

To remove the patch:

  • Peel smoothly away from the skin starting at one edge 
  • Fold the patch in half sticking the sticky side together 
  • Place in your household rubbish, keep away from children and pets 

What dosages are there? 

Each Evorel 50 patch delivers 50mg of estradiol per day. Each Evorel Conti patch delivers 50mg of estradiol and 170mg of norethisterone per day. You use the patches one at a time and change them twice a week. The memory pack will help you keep track of this. 

On weeks 1 and 2 you use the Evorel 50 patches. 

On weeks 3 and 4 you use the Evorel Conti patches. 

When do you start using Evorel Sequi?  

If you are still having periods, start your first patch within 5 days of bleeding. If you are already on a different HRT, start your first patch at the end of a treatment cycle or within one week of stopping. Otherwise, you can put on your first patch straight away. 

What are the side effects of Evorel Sequi? 

As with all medicines, Evorel Sequi comes with some side effects, although not everyone will get them. The following diseases are reported more often in women using HRT compared to women who aren’t: 

  • Ovarian cancer 
  • Breast cancer 
  • Heart disease 
  • Stroke 
  • Abnormal growth or cancer of the lining of the womb 
  • Blood clots in the leg veins or lungs 
  • Probable memory loss if HRT is started over the age of 65 

Be aware of the following when using Evorel as they may be signs of a serious problem: 

  • Migraine for the first time 
  • Blood clots or stroke 
  • Yellowing skin or white of the eyes (jaundice) 
  • Sudden swelling of the face or throat, difficulty breathing 
  • An increase in blood pressure 
  • Convulsions or fits 
  • Breast cancer or ovarian cancer 

If any of these occur take off the patch straight away and seek urgent medical assistance. 

Very common side effects, affecting more than 1 in 10 people: 

  • Irritated, itchy red skin where the patch has been applied 

Common side effects, affecting less than 1 in 10 people: 

  • Unsteady emotions 
  • Insomnia 
  • Feeling depressed or nervous 
  • Headache 
  • Feeling sick 
  • Upset stomach 
  • Diarrhoea 
  • Breast pain 
  • Weight gain  
  • Heavy vaginal bleeding 
  • Water retention 

Uncommon side effects, affecting less than 1 in 100 people: 

  • Dizziness 
  • Allergic reaction 
  • Numb or tingly hands or feet 
  • Irregular bleeding 
  • Thickening of the womb lining 
  • Thrush 
  • Changes in libido 
  • Feeling tired 
  • Concentration problems 

Uncommon sides effects, affecting less than 1 in 100 people: 

  • Varicose veins 
  • Skin discolouration 
  • Vomiting 
  • Dizziness 
  • Abnormal liver function tests 

In rare cases, you may experience the following; affecting less than 1 in 1,000 people: 

  • Muscle weakness 
  • Benign growth in the uterus 
  • Cysts close to the fallopian tube 
  • Cervical polyps 
  • Gallstones 

When shouldn’t you use Evorel Sequi? 

You shouldn’t use Evorel Sequi if: 

  • You have or have ever had breast cancer 
  • You are allergic to anything in the patches
  • You have thickening of the womb lining
  • You have or have ever had cancer that is made worse with oestrogens
  • You have unexplained vaginal bleeding
  • You have an increased risk of blood clots
  • You have ever had a blood clot in a vein or lung
  • You have or have ever had a liver disease and your liver function tests have not returned to normal
  • You have ever had blocked arteries
  • You have a blood problem called porphyria

If any of these appear for the first time while using Evorel Sequi seek immediate medical assistance. You may also need to take special care with Evorel Sequi if you have any of the following: 

  • A family history of breast cancer or ovarian cancer 
  • High blood pressure 
  • Diabetes 
  • Gallstones 
  • You’ve ever had a problem caused by the growth of the womb lining (fibroids, endometriosis) 
  • You’ve ever had unexplained vaginal bleeding 
  • Epilepsy 
  • Asthma 
  • Migraines 
  • Breast problems 
  • Thyroid problems 
  • Otosclerosis 
  • A history of sudden swelling in the face or throat 
  • High levels of fat in your blood 

If any of these apply to you, you can still take Evorel Sequi but you will need to have more frequent check-ups so you can be closely monitored by your doctor. 

Does Evorel Sequi interact with other medications? 

You should always talk to your doctor about any other medication you are taking, including complementary medicines as these may interfere with Evorel Sequi or vice versa. It is particularly important you let your doctor know if you are taking any of the following: 

  • Medicine for Hepatitis C 
  • St. John’s Wort 
  • Medication for epilepsy 
  • Certain medicines for tuberculosis 
  • Medicine for HIV infection 
  • Bosentan for high blood pressure 

Where can you buy Evorel Sequi? 

You can buy Evorel Sequi from any pharmacy, wherever it’s convenient for you, pop to your local chemist or supermarket or order online. 

Can I get Evorel Sequi without a prescription? 

You cannot buy Evorel Sequi without a prescription, you will need to talk to a doctor so they can assess if the medicine is suitable for you and weigh up any risks involved with your medical history. 


Jannsen-Cilag Ltd Evorel Sequi Patient Leaflet (June 2016) Retrieved from Menopause symptoms (March 2019) Retrieved from 

NHS UK Menopause Treatment (August 2018) Retrieved from