Motilium is a common form of anti-nausea and sickness medication that's used to protect against feelings of sickness or discomfort in people with a range of conditions. This is the branded version of a generic drug called domperidone, which is the active ingredient in Motilium. More information

A doctor will review your order and write you a prescription, if appropriate. This prescription is then forwarded to a pharmacy. The pharmacy will have your medicine delivered to you within one to three working days. Read more about this process here.

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Motilium is a medication that uses the active ingredient domperidone as a strategy for reducing the risk of nausea and vomiting. This substance can be used for the treatment of gastrointestinal disorders, and it may also be administered as an antiemetic, with drugs like apomorphine to prevent feelings of sickness that may arise from similar drugs.

What is Motilium? 

Motilium is a common form of anti-nausea and sickness medication that's used to protect against feelings of sickness or discomfort in people with a range of conditions. This is the branded version of a generic drug called domperidone, which is the active ingredient in Motilium. The active substance in this pill helps to move the stomach contents through the intestines at a more rapid pace, which can reduce the feelings of discomfort that might lead to vomiting.  

Additionally, this substance can reduce the signals that are sent to the brain that encourage vomiting, meaning that you're less likely to feel as though you need to throw up. However, the medication will not get rid of the underlying issue that is causing the nausea or vomiting. You will need to talk to your doctor about a treatment that's suitable for the underlying condition.  

When is Motilium used? 

Motilium will not be given to solve any instance of nausea or vomiting, as it only treats a symptom of a condition, not the underlying problem itself. However, some doctors will prescribe this drug if you are having trouble keeping food or water down because of a gastrointestinal problem or travel sickness. They may also recommend using Motilium if you feel nausea after taking a certain medication that's crucial for your recovery from a different illness.  

Motilium is intended to get rid of the symptoms of nausea and sickness very quickly, and they can work well for children over the age of 12 and adults. It is important not to take Motilium if you are nursing, as it passes into breast milk. 

How do you use Motilium? 

When your doctor prescribes Motilium for your nausea or sickness problems, they will often give you some basic instructions on how to take the medication safely and avoid any unnecessary side effects. You will also be able to find information about how to safely use and store your medication on the leaflet inside of the medication packet. It's important to follow the instructions given by your doctor carefully, even if they don't correspond with the information that you find within the medication packet.  

Motilium is often prescribed in pill form, which means that it needs to be taken by mouth. Generally, it's best to take this substance at least thirty minutes before you plan on eating something, or 30 minutes before going to bed at night. You can take Motilium with a glass of water, and the medicine often acts fast on your system, so you should start to notice the results straight away. It's important not to take more Motilium than your doctor prescribes as this can increase your risk of side effects.  

Although your doctor will tell you how long you should be taking Motilium it is generally not a good idea to take anti-sickness medications like this one for longer than 7 days consecutively. If you continue to throw up after taking Motilium, or you do not feel any better after taking the tablets according to your doctor’s instructions for a few days, tell your healthcare professional. They may want to move you onto a different anti-sickness medication.  

In situations where Motilium is prescribed for a longer period, your doctor may wish to perform an ECG on your heart to make sure that it is safe to proceed.

What dosages are available? 

Unless your doctor prescribes otherwise, the most common dose for Motilium is 1 tablet containing 10mg of domperidone taken three times per day. It is also possible to get Motilium in an oral suspension liquid if you have a hard time taking a tablet. This is available in a dosage of 1mg of domperidone for every 200ml of liquid.  

The tablets and oral suspension form of Motilium may not be suitable for children under the age of 12. Do not take more of this medication than your doctor prescribes. If you believe that you may have been accidentally exposed to an overdose, you should contact an emergency healthcare professional immediately. Symptoms of an overdose may include confusion, dizziness, drowsiness, irregular heartbeat and rigidity in the muscles.  

If you miss a dose of Motilium when you usually take it, make sure that you take your tablet as soon as you remember. However, if it is almost time for your next dose of medication, you can skip the dose entirely and carry on with your schedule as normal. Do not take double the number of tablets you usually take to make up for a missed pill. 

What are the side effects of Motilium? 

All medications, including Motilium can cause side effects in some people. Different patients will react to this medication in different ways, which means that you may or may not experience side effects. If you do notice some minor symptoms after taking Motilium, you may find that they go away by themselves naturally as your body gets used to the medication. If the side effects that you experience continue or worsen, contact your doctor.  

The most common side effects of Motilium include: 

  • Dizziness and confusion 
  • Headaches 
  • Dry mouth 
  • Nervousness or irritability 
  • Flushing  
  • Trouble sleeping 
  • Stomach cramps 
  • Leg cramps 
  • Hot flashes 

Although it's rare for people to experience serious side effects when taking Motilium, you may notice some more dangerous symptoms when taking this medication in some cases. Tell your doctor immediately if you experience chest pain, a change to your heart rhythm, or swelling in your ankles or feet. You should also speak to a doctor immediately if you have difficulty urinating, swelling in the breasts, and discharge from the nipple in both men and women.  

In women, menstrual changes may take place when taking this medication. If they do, speak to a doctor immediately. You should also contact a doctor or pharmacist if you see any changes in your sexual performance or drive.

When shouldn't you use Motilium? 

Motilium may not be a suitable treatment for all people suffering from nausea. It is important to share your complete medical history with your doctor before taking this drug, to ensure that it is safe for you to take. If you have a history of breast cancer, this medication may be particularly dangerous.

Do not use this medication without your doctor's approval if you: 

  • Are allergic or sensitive to any of the medications used in Motilium 
  • Suffer from bleeding in the stomach or regularly have stomach pains 
  • Produce black stools or suffer from a blocked or perforated gut 
  • Suffer from a tumor in the pituitary gland or severe liver disease 
  • Have any heart disease issues or defects 
  • Have an unusual level of magnesium or potassium in your blood 

This medication should only be used if absolutely necessary for people who are pregnant or are considering getting pregnant. Due to the potential risks of this medication for an infant. Although Motlium does promote breast milk production, it is generally not recommended to use this for milk production as the risks generally outweigh the benefits, your doctor will advise you.

Does Motilium interact with any other medications? 

Many medications can interact with other drugs that you may be taking for various reasons. Because of this, it's important to make sure that you tell your doctor about all other substances that you might be taking when you're using Motilium. Do not begin using any new medication with this substance without getting your doctor's approval first. Tell your doctor about prescription medications that you are taking, as well as over the counter and recreational drugs. It's also worth mentioning any herbal tablets or supplements that you are taking.  

Motilium does not interact well with certain substances. For instance, MAOIs like selegiline and furazolidone can affect the way that this medication is absorbed into the bloodstream. At this time, there isn't a lot of research into the different medications that may affect the functioning of Motilium. Your doctor will consider your condition and the other substances that you might be exposed to carefully when deciding whether to prescribe this medication.

Where can you buy Motilium? 

It is possible to order Motilium to purchase at offline and online pharmacies within the EU, however this medication may not be available in some parts of the US. We can have this drug delivered to a local EU pharmacy on your behalf, and for prescription medications like this one, we can also arrange for a consultation with a registered doctor too.

Can you get Motilium without a prescription?  

Motilium is not safe to use without a prescription. You will need to speak to your doctor about your condition and any symptoms that you are having before you can begin using this medication. Your doctor will consider your medical history and any background you might have that may make it dangerous to take Motilium. If you are not suitable to take Motilium, then your doctor will be able to suggest another anti-sickness medication that might be safer for you to use.  


References, online, 2019, Domperidone maleate tablets, [Accessed on the 15th of August 2019], Available at:

IBM Micromedex, Online, 2019, Domperidone oral route, [Accessed on the 15th of August 2019], Available at:, online, 2019, Domperidone - oral, [Accessed on the 15th of August 2019], Available at:  

Assessed by:

Dr Imran Malik, General practitioner
Registration number: GMC: 4741365

Dr Imran Malik studied undergraduate medicine at King's College University in Central London and clinical studies at the prestigious King's College Hospital. He graduated with a MBBS degree in 2000 and went on to gain postgraduate memberships with the Royal Society of Medicine and also General Practice in 2006.