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What is Nuvelle?
Nuvelle tablets contain estradiol and norethisterone, two female sex hormones. This hormone replacement therapy (HRT) preparation is used in menopausal women. Nuvelle reduces the symptoms of menopause by supplementing hormone deficiencies in women going through menopause. Nuvelle is a prescription-only medicine.
What is Nuvelle used for?
Women reach menopause around the age of 45. During this period their ovaries produce less and less oestrogen, and oestrogen levels decline as a result. The declining levels of oestrogen can cause distressing symptoms, such as:
- Irregular periods;
- Hot flushes;
- Excessive sweating;
- Dryness of mucous membranes (eyes, vagina and/or mouth);
- Pain during sex or loss of libido;
- Osteoporosis (decrease in bone mass and density).
Nuvelle stabilises oestrogen levels by supplying the body with extra oestrogen (in this case in the form of estradiol). This helps reduce menopausal symptoms. Nuvelle also contains a progestogen hormone, norethisterone, which protects the lining of the uterus from side effects. Nuvelle is usually used to treat women who have not had a hysterectomy.
How to use Nuvelle
Nuvelle comes in blister packs containing 28 tablets: 16 white tablets and 12 pink tablets. One white estradiol-only tablet is taken every day for 16 days. Then one pink tablet is taken for the next 12 days. The pink tablets contain both estradiol and norethisterone. Most women will have a monthly withdrawal bleed during the fourth week of their cycle. You start the next pack right after you take the last tablet, even if you are still bleeding.
Unless otherwise instructed by a doctor, the usual dose in adult women is:
- one tablet once daily.
Do not exceed the recommended dose and read the package leaflet carefully before use.
HRT preparations can cause side effects. The following are some of the side effects that are known to be associated with Nuvelle:
- Gastrointestinal symptoms;
- Breakthrough bleeding (spotting);
- Vaginal discharge;
- Breast tenderness or soreness;
- Mood swings.
Consult a doctor if these or other symptoms are severe or persistent. Read the package leaflet carefully before use. The package leaflet will also tell you that all women using HRT have a slightly increased risk of serious side effects such as cancer and thrombosis compared with women who don't use HRT.
When not to use Nuvelle
Nuvelle is not suitable for everyone and should not be used if:
- You are allergic to estradiol, norethisterone or any other ingredient in this medicine;
- You have a known or past history of thrombosis, embolism (blood clot in the lung), liver disease, breast cancer or other hormone-related cancer;
- You have vaginal bleeding of unknown cause or an overgrowth of the lining of the womb (endometrial hyperplasia);
- You have a serious kidney or blood disease.
Consult a doctor on the use of Nuvelle if you have a health condition that is not listed above or are currently on medication.
Nuvelle is intended for use in menopausal women. The following advice applies to women who are still in the fertile age bracket:
- Do not use Nuvelle if you are pregnant or breastfeeding, unless otherwise instructed by your doctor.
Warning: Nuvelle is not a contraceptive pill! If you are still capable of becoming pregnant you should use a contraceptive of some kind as a precaution. Nuvelle does not interact with alcohol or affect your ability to drive safely.