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Attention please: Premique has been discontinued by the manufacturer. Please follow this link to find other medicines in the category Hormone Replacement Therapy.
What is Premique?
Premique is a hormone replacement therapy (HRT) preparation for menopausal women. Premique tablets contain two active ingredients: estradiol and medroxyprogesterone. These are forms of the main female sex hormones oestrogen and progesterone. Women's ovaries gradually produce less and less oestrogen in the period up to the menopause, and oestrogen blood levels decline as a result. The declining levels of oestrogen can cause distressing symptoms. Premique tablets supplement hormone deficiency, which helps reduce or eliminate these symptoms. Premique is a prescription-only medicine.
What is Premique used for?
Premique tablets are used to relieve menopausal symptoms, including:
- Hot flushes;
- Excessive sweating (night sweats);
- Sleeping difficulties;
- Dryness of eyes and/or vagina;
- Mood swings.
Premique contains a low dose of a progesterone hormone, which protects the lining of the uterus from side effects. This medicine is therefore usually used to treat women who have not had a hysterectomy.
How to use Premique
Premique tablets should be taken at the same time each day with some water. The tablets may be taken with or without food. Premique comes in convenient blister calendar packs marked with the days of the week, which should be taken back to back. Because there is no tablet-free interval, Premique does not produce a withdrawal bleed. Do not use this medicine for more than two years in a row without consulting a doctor.
Unless otherwise advised by the doctor, the usual dose in adults is:
- one tablet once daily.
Always follow the prescription exactly - never take more or less than the doctor recommends. Read the package leaflet closely before use.
Premique tablets may cause side effects, including:
- Breast tenderness or soreness;
- Gastrointestinal symptoms;
- Breakthrough bleeding. This can last up to several months. If it doesn't stop, consult a doctor;
- Increase in vaginal discharge.
Consult a doctor if these or other side effects are severe. It is important to be aware that all women using HRT have a slightly increased risk of being diagnosed with cancer and thrombosis compared with women who don't use HRT. For more information, see the package leaflet.
When not to use Premique
Premique is not suitable for everyone and should not be used if:
- You are allergic to estradiol, medroxyprogesterone or any other ingredient in this medicine;
- You have a known or past history of breast cancer, cancer of the lining of the womb (endometrial cancer) or any other hormone-related cancer;
- You have a condition affecting the lining of the womb;
- You have a known or past history of blood clots in the veins (thrombosis) or certain blood, heart or vascular disorders;
- You have a liver condition.
Consult a doctor on the use of Premique if you have a health condition that is not listed above or are currently on medication. For more information on contraindications and interactions, see the package leaflet.
Premique is usually given to women who are no longer in the fertile age bracket. Women who don't fall within this group and who are pregnant, planning to conceive or breastfeeding should not use Premique without consulting a doctor first. Caution: Premique is not an oral contraceptive! If you are still capable of becoming pregnant you should use a form of contraception as a precaution. This medicine does not interact with alcohol or affect your ability to drive safely.