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Provera

The active substance in Provera is medroxyprogesterone.  Medroxyprogesterone is prescribed for the treatment of various complaints and disorders, such as cancer and gynaecological disorders. This product text is about the use of Provera for gynaecological complaints.

What is Provera?

The active substance in Provera is medroxyprogesterone. 
Medroxyprogesterone is prescribed for the treatment of various complaints and disorders, such as cancer and gynaecological disorders. This product text is about the use of Provera for gynaecological complaints.

How does Provera work?

Medroxyprogesterone has approximately the same effect as the female hormone progesterone. It is used to treat menstrual problems, such as severe pain or a lot of blood loss, and irregular periods. It is also used to treat endometriosis (proliferation of uterine mucosa), menopausal symptoms and to investigate the cause when a woman is not menstruating.

How to take Provera?

Check the pharmacy label for the correct dosage and follow the instructions given by your doctor.  
 
The doctor may prescribe medroxyprogesterone in various ways depending on the reason for which you are using it. 
 
You may need to use the medicine every day for a few weeks to months (continuous use). The use during a certain period of the menstrual cycle is usually one dose per day (cyclic use). The first day of menstruation is called ‘day 1’. 
 
You can take the medicine at any time of the day. It is best to choose fixed times, for example, in the morning at breakfast. Or if you take the medicine 3 times a day: at breakfast, lunch and dinner so that you are less likely to forget a dose. 
 
This medicine is usually prescribed for a few days or weeks a month, depending on your condition. 
 
You should usually take Provera for a few months before you know whether it works properly. Your periods may be irregular in the beginning. If this continues, consult your doctor as you may need a higher dosage. If you stop taking Provera, you may miss a period or two, especially if you have taken it for several months. 
Do not use if you are pregnant.

What are the possible side effects of Provera?

In addition to the desired effect, this can cause drug side effects. 
 
The main side effects are the following: 
 
Rarely (affects 1 to 10 in 100 people) 
 
Irregular blood loss (‘spotting’). This should disappear after a while, menstruation will then become regular. If you continue to suffer, consult your doctor. Sometimes it is necessary to temporarily increase the dose. 
Cessation of menstruation.  
 
Very rare (affects less than 1 in 100 people) 
 

  • Gastrointestinal complaints such as nausea or constipation; 
  • Sore or tense breasts; 
  • Headache or migraine; 
  • Dizziness, sleepiness or fatigue; 
  • Water retention (thick ankles and feet); 
  • Skin disorders, such as acne, itching, brown spots on the skin or skin irritation under the influence of sunlight, oily skin and oily hair; 
  • excessive hair growth or hair loss; 
  • Changes in mood, such as irritability, nervousness or depression; 
  • Change in libido, dry vagina and pain during sex; 
  • Liver disorders; 
  • Hypersensitivity to this drug; 
  • Thrombosis, in which a blood clot can block a blood vessel. 

 
Consult your doctor if you experience any of the side effects listed above or if you have other side effects that you are concerned about.

When is it not safe to take Provera?

Do not take Provera if you have ever had liver disease, breast or uterine cancer, a history of thrombosis, or abnormal vaginal bleeding the cause of which has not been diagnosed by a doctor.

Pregnancy / Breastfeeding / Driving / Alchohol

Do not take Provera if you are pregnant as it can harm your unborn baby. Provera is safe to use when breastfeeding.  
There are no restrictions on driving and drinking alcohol.