Spedra or Avanafil is an orally administered drug used to treat impotence or erectile dysfunction. This medication belongs to a class of medications called phosphodiesterase inhibitors. More information

A doctor will review your order and write you a prescription, if appropriate. This prescription is then forwarded to a pharmacy. The pharmacy will have your medicine delivered to you within one to three working days. Read more about this process here.

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Spedra is the brand name for a drug called Avanafil, used to treat male sexual function problems like erectile dysfunction, or impotence. When combined with sexual stimulation, avanafil works by increasing blood flow to the penis, helping men to get and maintain their erection. Spedra works when combined with sexual stimulation. It is not an aphrodisiac and does not protect against sexually transmitted infections or diseases.  

What is Spedra? 

Spedra or Avanafil is an orally administered drug used to treat impotence or erectile dysfunction. This medication belongs to a class of medications called phosphodiesterase inhibitors. Similar drugs include Tadalafil, vardenafil, and sildenafil. Erection in the penis is caused by the blood vessels bringing blood to the penis and increasing in size so that they can deliver more blood to the penis at a rapid pace.  

Sexual stimulation leading to an erection also enables the release of nitric oxide in the penis. This results in the production of an enzyme called guanylate cyclase, which produces cyclic guanosine monophosphate. It's this cGMP that is responsible for increasing or decreasing the size of the blood vessels. When other enzymes destroy cGMP, the blood vessels return to their normal size, and the erection diminishes. Using phosphodiesterase-5, Spedra prevents cGMP from being destroyed and allows it to stick around for longer. The presence of cGMP ensures a longer erection. Spedra was FDA approved in 2012.

When is Spedra used? 

Spedra is the brand name used for the erectile dysfunction medication, Avanafil, which helps to treat men over the age of 18 who experience erectile dysfunction symptoms. Spedra works to help men maintain and achieve erections that are hard enough for sex - usually within periods of 15 to 30 minutes.  

Similarly to other ED medications, Spedra helps men to get and maintain erections if they are already sexually aroused. Crucially, this substance is not used to cure erectile dysfunction. Instead, the medicine helps with the treatment of the condition. If you're interested in trying Spedra, you will need to speak to your doctor to find out whether this medication is suitable for you. If Spedra is not the right treatment for your impotence issues, your doctor might prescribe a different kind of medication. Never take more Spedra then you are prescribed.  

How do you use Spedra? 

When you're given Spedra, it's essential to follow the instructions provided by your doctor, pharmacist, and the information leaflet included in the medication. If you have any questions, speak to a doctor before taking Avanafil. This type of erectile dysfunction medication is administered by mouth and can be taken safely both with and without food, according to your doctor's directions. Usually, you will be asked to take Spedra before you intend to have sex. It is best to take Spedra at least fifteen to thirty minutes before sexual activity. Follow the instructions provided by your doctor carefully, and do not take more than one dose per day. Spedra most only be taken once per day. Taking more than the recommended dose of this medication will not cause the substance to work any better. Instead, an overdose of Spedra can lead to serious side effects.  

What dosages are available? 

There are different dosages of Avanafil available. Your doctor will prescribe the dose most suitable for you based on the way you respond to treatment, your medical condition, and any other medications you might be taking. Make sure that you tell your pharmacist or doctor about all the products you use besides Spedra. This includes prescription drugs, herbal products, supplements, and no-prescription drugs. 

For most people, the recommended starting dose for Spedra will be around 100mg per day, which is taken 30 minutes before sexual activity. If the recommended starting dose is not correct for your needs, your doctor may reduce it to 50mg a day, or 200mg per day. People who are taking medications to moderately increase the blood levels of Spedra should not exceed a total of 50mg of avanafil per day.  

What are the side effects of Spedra? 

Spedra is an FDA-approved and safe form of erectile dysfunction treatment. However, side effects may occur in some people. The most common side effects of this drug include dizziness, flushing and headaches. If your symptoms persist or worsen, speak to your doctor.  

If you have a heart condition, remember that sexual activity, with or without avanafil could increase the strain on your heart. If you experience any heart-related pains, discomfort in your left arm, chest, or jaw or dizziness during sex, stop what you're doing and get medical help immediately. Nausea and fainting are also signs of something going wrong. In rare cases, some patients taking Spedra may experience a sudden reduction in their vision, including blindness in both or one of their eyes. If this issue happens to you, stop taking Spedra, and get medical help. You may have a slightly higher chance of developing vision problems if you have high cholesterol, diabetes, heart disease, and other eye problems. You can also suffer more from these conditions if you are over the age of 50, have high blood pressure, or if you smoke. 

In other rare cases, you may experience a decrease or reduction in your ability to hear. Some symptoms include dizziness and a ringing in your ears. If this happens to you, make sure to seek medical attention as quickly as possible. When taking any erectile dysfunction medication, including Spedra, it's essential to seek emergency help if you suffer from a prolonged or painful erection lasting longer than 4 hours. Permanent problems may occur if you do not seek help. Serious allergic reactions to Spedra are rare. However, you should seek medical help immediately if you notice any symptoms of an allergic reaction, including itching, rashes, or swelling. Swelling of the tongue, face, and throat are particularly dangerous, as is trouble breathing.  

When shouldn't you use Spedra? 

There are multiple types of erectile dysfunction medication on the market today, aside from Avanafil. You may find that because of your specific medical background, Spedra is not right for you. Speak to your doctor before beginning your prescription if you have an allergy to Avanafil or any other allergies. 

It is crucial to share your entire medical history with your pharmacist or doctor before getting Spedra. This includes any history of heart problems, such as irregular heartbeats or heart attacks in the last six months. Discuss any chest pain or angina, risk of heart failure, and any susceptibility to stroke that you may have.  

Other particularly dangerous conditions to take Spedra with include kidney disease, liver disease, and low blood pressure. Penis conditions such as Peyronie's disease, or angulation can also cause complications. If you have a history of painful and prolonged erections, speak to your doctor. If you have any conditions such as leukemia, sickle cell anemia, or multiple myeloma may increase your risk of priapism, be cautious taking Spedra. Avanafil should not be taken by people with eye problems, bleeding disorders, or active stomach ulcers. Additionally, it's worth noting that this medication can make some people feel dizzy or cause vision changes. Make sure that you avoid driving and using heavy machinery if you feel uncertain about your abilities.  

Does Spedra interact with any other medications? 

As with many erectile dysfunction medications, Spedra may interact with other drugs that you are taking for a range of conditions. Make sure that you check the complete list of interactions that you receive with your medication. Additionally, ensure that you share information about all of the drugs that you may be taking with your doctor, including herbal medications, non-prescription, and prescription medications. 

One common drug that interacts with Spedra is riociguat. Additionally, you should not be taking Spedra with any other medications intended to treat erectile dysfunction. Do not take Spedra with any other medicines used to treat pulmonary hypertension.  Avanafil can sometimes cause drops in your blood pressure when used with nitrate medication. This can lead to both fainting and dizziness. In rare circumstances, your use of Spedra and nitrates may lead to a stroke or heart attack. Do not take Spedra with nitroglycerine, or isosorbide.  

If you are currently taking an alpha-blocker medication to address heart pain or chest pain issues, avoid taking this medication along with Avanafil. Your blood pressure can get too low when taking medications like tamsulosin and doxazosin. Your doctor may try you on a lower dose of this medicine to reduce your risk of blood pressure issues. Do not take Spedra with: 

  • Tamsulosin 
  • Doxazosin 
  • Alfuzosin 
  • Prazosin 
  • Ketoconazole 
  • Clarithromycin 
  • Disopyramide 
  • Ethromycin 
  • Haloperidol 
  • HIV protease inhibitors like atazanavir, idinavir, or ritonavir 
  • Medications for an irregular heartbeat or high blood pressure 
  • Medications for erectile dysfunction 

Spedra is not usually used to treat women. Remember that herbal medications can also have an impact on the way your body metabolizes Spedra, particularly St John's Wort.  

Where can you buy Spedra? 

Spedra and Avanafil can be purchased from a registered pharmacy after you have completed a consultation with a doctor. Remember that you should always speak to your GP if you have erection problems, no matter how uncomfortable you feel. In some cases, ED may be a sign that you're experiencing an underlying condition. Erectile dysfunction can indicate the presence of heart disease, diabetes, high blood pressure and more. These conditions can also be caused by psychological issues like depression, anxiety, and stress. Speaking to your doctor will ensure that you get the right treatment to address the underlying cause of your ED.  

Can you get Spedra without a prescription?  

It is not possible to safely purchase Spedra without a prescription online or offline. However, you can safely order the medication if you do have a prescription, or if you have completed a full medical assessment with a registered doctor and have been given an order for Spedra. Your doctor will need to check that Spedra will not interact negatively with any other medications that you're taking, or anything else in your lifestyle, before giving you this prescription. Do not take Spedra without first getting a medical consultation.  




A Menarini Farmaceutica Internazionale SRL, Last updated 23rd of April 2018, Spedra 50mg tablets, Retrieved from: https://www.medicines.org.uk/emc/product/5331/smpc  

RXlist, Accessed 27th of April 2019,  Stendra Drug, Retrieved from: https://www.rxlist.com/stendra-drug.htm  

NICE, Accessed on 27th of April 2019, Avanafil, Retrieved from: https://bnf.nice.org.uk/drug/avanafil.html  

Assessed by:

Dr Wouter Mol, General practitioner
Registration number: BIG: 9057675501

Dr Wouter Mol studied medicine at the University of Groningen. From 2002 to 2003, he served as a resident in neurology, and from 2003 to 2005 he served his residency training in internal medicine and emergency medicine. Wouter Mol has been working as a GP since 2005.