Tridestra is currently out of stock. In the category Hormone Replacement Therapy (HRT) you will find alternatives.



Tridestra is a hormone replacement therapy (HRT) preparation. It contains two active ingredients: estradiol (an oestrogen hormone) and medroxyprogesterone (a progestogen hormone). More information

A doctor will review your order and write you a prescription, if appropriate. This prescription is then forwarded to a pharmacy. The pharmacy will have your medicine delivered to you within one to three working days. Read more about this process here.

Patient Leaflet(s)

What is Tridestra?

Tridestra is a hormone replacement therapy (HRT) preparation. It contains two active ingredients: estradiol (an oestrogen hormone) and medroxyprogesterone (a progestogen hormone). Tridestra tablets are used to treat menopausal symptoms in women. Tridestra is a prescription-only medicine.

What is Tridestra used for?

Women's ovaries gradually produce less and less oestrogen in the period up to menopause, and oestrogen levels decline as a result. The declining levels of oestrogen can cause distressing symptoms. The most common menopausal symptoms include:

  • Hot flashes;
  • Vaginal discomfort (dryness, pain, irritation);
  • Difficulty falling asleep or staying asleep;
  • Osteoporosis (decrease in bone mass and density);
  • Night sweats;
  • Mood swings.

HRT restores hormonal balance. This helps relieve menopausal symptoms. Tridestra is intended for women with an intact womb because it contains a progestogen hormone which protects the lining of the womb from side effects. Tridestra produces a withdrawal bleed every three months.

How to use Tridestra

Tridestra is based on a three-monthly cycle. Each package contains three numbered blisters.

  • Blister no. 1 contains white tablets. These tablets are taken for the first 70 days and contain just estradiol.
  • Blister no. 2 contains blue tablets, which are taken for days 71 to 84. These tablets contain estradiol and medroxyprogesterone.
  • Blister no. 3 contains yellow tablets. These tablets are taken for days 85 to 91 and contain no active ingredient at all (placebo).

The three-monthly cycle results in a withdrawal bleed every three months (between day 85 and day 91). You start the next pack (blister 1) right after you finish the third blister, even if you are still bleeding.


Unless otherwise advised by a doctor, the usual dose in adult women is:

  • one tablet, once daily.

Read the package leaflet before use.

Side effects

HRT may cause side effects. The following are some of the side effects that are known to be associated with Tridestra:

  • Headache;
  • Breast tenderness;
  • Gastrointestinal symptoms such as nausea and stomach ache;
  • Breakthrough bleeding (spotting).

Consult a doctor if the side effects are persistent. See the package leaflet for a full list of side effects, including rare yet serious side effects such as cancer and thrombosis.

When not to use Tridestra

Tridestra is not suitable for everyone and should not be used if:

  • You are allergic to estradiol, medroxyprogesterone or any other of its ingredients;
  • You have a known or past history of breast cancer, endometrial cancer or other hormone-related cancer;
  • You have vaginal bleeding of unknown cause;
  • You have an overgrowth of the lining of the womb (endometrial hyperplasia);
  • You have a blood clot in a vein (thrombosis) or the lungs (pulmonary embolism) or a history of this;
  • You have a blood disorder or liver disease.

Consult a doctor on the use of Tridestra if you have a health condition that is not listed above or are currently taking medication.

Pregnancy/driving ability/alcohol

This medicine is intended for women who are no longer in the fertile age bracket. The following advice applies to women who don't fall within this group:

  • Tridestra should not be used during pregnancy and while breastfeeding.

Warning: this medicine is not a contraceptive pill! If possible pregnancy is to be avoided then some method of birth control should be used. This medicine does not interact with alcohol or affect your ability to drive safely.