Triregol are a hormonal contraceptive pill that belong to the family of "combined" pills. This means that Triregol has two active ingredients, levonorgestrel, and ethinylestradiol. More information

A doctor will review your order and write you a prescription, if appropriate. This prescription is then forwarded to a pharmacy. The pharmacy will have your medicine delivered to you within one to three working days. Read more about this process here.

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Triregol pills are a form of hormonal contraceptive. This medication belongs to the family of combined contraceptive pills, and contains the active ingredients levonorgestrel, and ethinylestradiol. The active ingredients in this medication are synthetic versions of naturally-occurring female hormones, estrogen and progesterone. 

What is Triregol? 

Triregol are a hormonal contraceptive pill that belong to the family of "combined" pills. This means that Triregol has two active ingredients, levonorgestrel, and ethinylestradiol. These synthetic versions of the female sex hormones allow Triregol to control aspects of the female menstrual cycle.  

Pills like this one adjust the typical menstrual cycle by adjusting the levels of female sex hormone in a woman's body. The daily amount of hormones in the pill trick the human body into believing that ovulation has already taken place, which means that eggs are not released from the ovaries.  

The hormones in Triregol increase the mucus thickness around the entrance to the room too, making it harder for sperm to enter the womb to reach an egg. In some cases, combined pills can also reduce the quality of the lining inside of the female womb, so that eggs cannot implant as normal.  

When is Triregol used? 

Triregol is used for the prevention of pregnancy, or as a "contraceptive" intended to stop women from falling pregnant following intercourse. In some cases, Triregol can also change the short-term symptoms of the menopause.  

As a hormonal contraceptive, Triregol can be used to help women who have particularly heavy or painful periods. The way that Triregol affects the menstrual cycle means that it can reduce the discomfort that women feel when they have their periods, and lead to much lighter bleeding.  

How do you use Triregol? 

Triregol belongs to a family of drugs known as triphasic pills, which means that you get three different kinds of tablets in each pack of 21 days. The tablets in the packet will have a slightly different dosage of hormones in them, which means that you need to be careful to take the right pills throughout the course of the month. There are 6 pink tablets in the packet which contain 50 micrograms of levonorgestrel, and 30 micrograms of ethinylestradiol. Additionally, the five white tablets in the packet contain up to 75 micrograms of levonorgestrel, and 40 micrograms of ethinylestradiol.  

A pack of 21 Triregol pills will also contain 10 ochre colour pills which contain 125 micrograms of levonorgestrel and 30 micrograms of ethinylestradiol. When taking Triregol, you will need to make sure that you are using them in the order that is specified on the packet. The packet will be labelled with numbers to tell you when you should be taking each pill. One tablet will be taken for every day of a 21 day cycle, then you'll take a 7 day break from using Triregol. During your break, you may notice a bleed that is similar to having a normal period.  

In the week when you aren't taking any pills at all, you should still be protected from pregnancy, although vomiting and diarrhea may reduce the efficacy of these pills, so it's worth talking to your doctor if you have these conditions. Importantly, you must take Triregol at the same time each day, so it may be worth setting an alarm to tell you when to take it.  

The best time to begin taking Triregol is on the first day of your new cycle, or the first day of your period. This should ensure that you are immediately protected against pregnancy. Speak to your doctor if you are taking Triregol at any other time. 

What dosages are there? 

Triregol is offered in a single dosage, with three different measurements of hormones in each package. You will be required to take a single pill of Triregol each day for a period of 21 days. After those 21 days, you will have a 7 day break. If you forget to take a pill of Triregol one day at the correct time, take it as soon as you remember, unless another pill is due. Do not double up on pills to replace a missed tablet. 

If you have missed a tablet, or multiple tablets in a row, speak to your doctor about whether you may need to use an additional form of contraceptive to protect you against pregnancy.  

What are the side effects of Triregol? 

Most women will take Triregol without any negative side effects. However, all medications can cause side effects, and it is a good idea to be aware of what a pill can do, so that you can respond to the issue properly. The most common side effects of Triregol include abdominal pain, nausea, vomiting, breast tenderness, changes in weight, and water retention. Some people experience changes in their menstrual bleeding experiences, and vaginal thrush, while others have breakthrough bleeding periods.  

In some cases, you may suffer from periods of depression or changes in mood when you're taking Triregol, a rise in your blood pressure and a reduced sex drive. Some people experience reactions in their skin, including strange brown patches on the face or other areas of the body. In very rare circumstances, you may have disturbances in your liver function, increased risk of gallstones, and changes to the curvature of the cornea, which make it harder to wear contact lenses.  

It is possible for all hormonal pills to cause blood clots or increase your chances of blood clots in the blood vessels. With that in mind, it is important to be aware of any symptoms of clotting, including coldness or tingling in your extremities.  

When shouldn't you Triregol? 

Not all women will necessarily be suitable to take Triregol. Some women, such as those who are breastfeeding after giving birth, should not take any form of combined pill. It is also a good idea to avoid Triregol if you have ever had a blood clot in a vein or the lungs, or if you have a condition that may increase your chances of blood clots.  

If you have risk factors for getting blood clots, such as a family history of these conditions, or you're having treatment for varicose veins, you may need to avoid Triregol. This medication may not be suitable for women who have had heart conditions, strokes, heart attacks, or other issues caused by blood clots in an artery. If you have severe or moderate high blood pressure, avoid taking Triregol.  

Women over the age of 50, or women over the age of 35 who regularly smoke over 15 cigarettes per day, BMI> 39, should not take Triregol. Women who have severe diabetes or have migraines with aura symptoms should avoid Triregol too. If you have a history of breast cancer, make sure that you check that this pill is right for you. Other people who may not be able to take Triregol include: 

  • Women with abnormal bleeding of the vagina; 
  • Women with long-term systematic lupus erythematosus; 
  • Women with a history of excess urea in the blood; 
  • Women with a history or active liver disease; 
  • Women with bile excretion disorders; 
  • Women with gallstones; 
  • Women with hereditary blood disorders; 
  • Women with rare galactose intolerance disorders. 

Avoid taking Triregol if you are allergic to any of the ingredients that are included in Triregol including the inactive ingredients. You should speak to your doctor about any allergies you have had, to be safe.  Your doctor will take these into account and assess your risk before advising the best contraception for you. 

Does Triregol interact with any other medications? 

It is possible for Triregol to respond negatively in the body when it is combined with other substances and medications that you are already taking. To ensure that you are safe, make sure that you tell your doctor about any medications that you are taking alongside Triregol, including pills that you have purchased over the counter and without a prescription. You should also make your doctor aware of any herbal or supplemental medications you are using.  

Do not take medications that speed up the breakdown of hormones by the liver, such as barbiturates or bosentan as well as others. St John's wort may also affect the way that Triregol works. Emergency contraceptive pills like Ellaone can make this medication less effective. If you need to use an emergency contraceptive when using Triregol, then you should also use an additional form of contraception for up to 14 days after using the emergency pill.  

The medication intended to support weight loss known as orlistat which is often available without prescription can cause severe bouts of diarrhea. If you are using medications that cause diarrhea or vomiting when you are using Triregol then you need to ask your doctor about whether you will still be protected against pregnancy.  

This pill could reduce the potency of cholesterol lowing medication, which means that you will need to take your cholesterol pills at least four hours before or after taking Triregol. Additionally, this pill could reduce the blood-sugar management effects of some pills used for diabetes. You may need to monitor your blood sugar more carefully when using Triregol  

This medication could reduce the impact of pills intended to reduce high blood pressure, so you will need to check your blood pressure regularly if you are already at risk or using medicines for high blood pressure when taking Triregol. If you have hypothyroidism and you are using Triregol, then you may need to take an increased dose of your thyroid medication, as Triregol can affect the way that thyroid hormones work.  

Sometimes, Triregol can decrease the amount of antiepileptic medications in your blood, increasing your risk of additional seizures.  

Where can you buy Triregol? 

Triregol will be available to purchase through partner pharmacies. It is not available without a consultation from a doctor, as not all people will be suitable to take Triregol as their form of oral contraception.  

Can you get Triregol without a prescription?  

Like most hormonal contraceptives, Triregol is not available without a prescription. You will need to have a consultation with a doctor and get a prescription to use Triregol. 

Sources, online, 2019, "Triregol coated tablets", [Accessed 14th of November 2019], Available at:, online, 2019, "Triregol", [Accessed 14th of November 2019], Available at:

Nice, online, 2019, "Contraceptives, Hormonal", [Accessed 14th of November 2019], Available at:



Assessed by:

Dr Imran Malik, General practitioner
Registration number: GMC: 4741365

Dr Imran Malik studied undergraduate medicine at King's College University in Central London and clinical studies at the prestigious King's College Hospital. He graduated with a MBBS degree in 2000 and went on to gain postgraduate memberships with the Royal Society of Medicine and also General Practice in 2006.