Fast home delivery
Professional and knowledgeable


Zumenon is a popular form of hormone replacement therapy or HRT treatment for women experiencing the menopause. Zumenon HRT helps to restore the balance in your hormonal levels and relieve some of the most common symptoms of menopause.

What is Zumenon?

Zumenon tablets are a form of hormone replacement therapy that uses the active ingredient of estradiol hemihydrate. This substance is a naturally occurring form of the female hormone oestrogen. With Zumenon tablets, it’s possible for women in the menopause to balance out their oestrogen levels, as oestrogen naturally starts to deplete when you enter the menopause stage. When you don’t have enough oestrogen in your system, the result can be irregular periods, mood swings, vaginal itching, night sweats, hot flushes, and other unwanted symptoms. However, with a treatment like Zumenon, it’s possible to replace some of the lost oestrogens in your system, ensuring that you can avoid some of the more upsetting side effects of the menopause. Zumenon is known as hormone replacement therapy. Zumenon HRT is a strategy that’s only intended for short-term use for relief from menopausal symptoms. You will need to review your treatment at least once each year with a doctor.

When is Zumenon Used?

Zumenon is a popular hormone replacement therapy treatment when women need a continuous form of oestrogen-only tablet for HRT. There are other pills for HRT that contain additional substances too. Because Zumenon only contains oestrogen, it is best suited for women who have already had a hysterectomy. If you have not had a hysterectomy already then you will need to take a progestogen medication along with Zumenon to reduce your chances of endometrial cancer. Oestrogen can increase your risk of this cancer significantly. Although using a progestogen tablet will not eliminate your risk entirely, it reduces the chances that you will suffer from a dangerous condition. If you have had your womb surgically removed already, then endometrial cancer is not a risk. Zumenon HRT may also be used for other forms of treatment.

For instance, your doctor may sometimes prescribe Zumenon HRT to help prevent or reduce your risk of osteoporosis during the post-menopausal stages. Sometimes, the declining levels of oestrogen in a women’s body can affect the bones and cause them to become more brittle. Oestrogen supplements help to prevent bone fractures and bone loss.

How do you Use Zumenon?

Your doctor will provide detailed guidance on how to use Zumenon when it is prescribed to you. Usually, you will need to take a tablet of Zumenon once a day consistently – just like taking a contraceptive pill. However, your doctor will need to regularly review your need to continue using this medication, as it is not a good idea to take an HRT treatment for too long. You can take your Zumenon tablets with a drink of water, either with or without food. Ideally, it’s best to take Zumenon at the same time each day, as this will help you to remember to take your pill. If you forget a dose of Zumenon for any reason, you can take the missed dose and then your next dose at the same time. If you miss a dose and it’s more than 12 hours after you should have taken it, then just skip that dose and take your next pill as usual.

You should not take a double dose of Zumenon to make up for a missed tablet.

What Dosages are Available?

The dosage of Zumenon prescribed to you may differ depending on your medical background. Zumenon 1mg and Zumenon 2mg are the most common dosages. Usually with HRT you start on the lowest possible dose, so Zumenon 1 mg. You may also need to take this pill with a separate progestogen-only pill if you have not had your womb removed. Unless recommended otherwise by your doctor, your usual dose will be one tablet per day, to be taken through a specific period.

What are the Side Effects of Zumenon?

Unfortunately, all medications can cause side effects. Your risk of side effects will depend on your genetic makeup and medical history. Some issues that occur after taking Zumenon 1 mg will disappear on their own as your body adjusts to the arrival of the new oestrogen replacement. However, if your symptoms worsen or persist, you should speak to a doctor.

Common side effects include:

  • Increased risk of thrush;
  • Nausea, vomiting, abdominal pain, indigestion, flatulence and bloating Increase in the size of uterine cysts;
  • Breast enlargement, tenderness or pain;
  • Fluid retention or swelling;
  • Migraine or headaches;
  • Premenstrual symptoms;
  • Depression or mood changes;
  • Weight changes;
  • Fatigue or dizziness;
  • Changes in sex drive;
  • Leg cramps;
  • Rise in blood pressure;
  • Changes in the corneal curvature;
  • Itching or rash;
  • Irregular changes of colour in the skin;
  • Gallbladder disease;
  • Disturbance in liver function;
  • Inflammation of the pancreas;
  • Blood clots.

It is very rare for anyone to have a severe allergic reaction to Zumenon. However, if you notice any itching, trouble breathing, or signs of swelling in the tongue, lips or throat, contact a medical health professional immediately. This is not a complete list of side effects. If you notice any other symptoms after taking Zumenon that you are concerned about it is important to speak to a doctor or pharmacist about your options.

When Shouldn't You Use Zumenon?

Zumenon will not be the most suitable treatment option for all people with menopausal symptoms. Women who have a high risk of developing cancers stimulated by oestrogen should not take this medication, for instance. This includes women with a history of breast cancer. Additionally, if you have fibroids in the womb or a history of endometriosis, your doctor will usually not prescribe Zumenon HRT.

If you are very overweight or obese, a severe smoker or you have varicose veins, your doctor may choose a different treatment for you. Zumenon 1 mg and Zumenon 2 mg may not be suitable for women with high blood pressure or diabetes either. Speak to your doctor if you have a high risk of getting blood clots, or you have blood clots in your family. Additionally, make sure your doctor is aware of any history of diabetes, raised levels of cholesterol, or gallbladder disease. Zumenon should not be taken by women with a long-term condition known as SLE. It is not ideal for women with migraines and severe headaches, or those with blood disorders like porphyrias. Women with a history of discolouration on their skin during previous use of contraceptive pills, HRT, or pregnancy might not want to take Zumenon either.

Zumenon tablets should not be used by:

  • Women who suffer from unexplained vaginal bleeding;
  • Women with a blood clot in the veins of the legs;
  • Women with disorders of the blood that may increase their risk of blood clots;
  • Women with inflammation caused by blood clots;
  • Women with a protein S or C deficiency;
  • Women with a history of heart attack or stroke caused by a blood clot;
  • Women with angina or severe chest pain;
  • Women with active problems with their liver, including liver disease or cancer;
  • Women who are breastfeeding or pregnant;
  • Women with rare hereditary disorders.

Discuss your full medical history with your doctor, including the history of your family members before you begin taking Zumenon to ensure that it is safe for you.

Does Zumenon Interact with Any Other Medications?

Medications for HRT can sometimes interact negatively with other substances that you are taking. When this happens, your risk of side effects can be increased, or you may find that it is dangerous to continue taking Zumenon. To ensure that it’s safe for you to take Zumenon HRT make sure that you tell your doctor and pharmacist about all the medications that you are using, including items that you bought over the counter, supplements, herbal medications, vitamins and recreational drugs. Do not start, stop or change the amount of any medication that you are taking when takin Zumenon tablets without checking with your doctor to ensure that the combination of the drugs is safe.

Various medications can reduce the blood levels of this medication in the human body. This could lead to symptoms like irregular bleeding or the increase of menopausal symptoms. Let your doctor know if you’re taking drugs such as efavirenz, crizotinib, barbiturates, cobicistat, or dabrafenib. If you have diabetes and your doctor prescribes Zumenon, you may need to make small adjustments to the amount of insulin or antidiabetic tablets that you take. You will need to monitor your blood sugar levels carefully. Zumenon can also have an impact on medicines used to raise or lower blood pressure. Your doctor will check your blood pressure levels periodically to check that you are safe. Zumenon can decrease the amount of a certain antiepileptic medication called lamotrigine in your blood, which may increase your risk of ongoing seizures, or seizures getting worse.

Where Can You Buy Zumenon?

You can purchase Zumenon from your local pharmacy or arrange for us to have this medication delivered for you to a registered EU pharmacy. For drugs like Zumenon which require a prescription, we can also arrange for a consultation with an official EU doctor.

Can You Get Zumenon without a Prescription?

It is not safe to get Zumenon in the EU without a prescription. Your doctor will need to conduct a full medical overview to ensure that this substance is suitable for you. Do not try to take Zumenon without getting your doctor’s approval first.


Mylan, EMC,, online, 2019, Zumenon 1mg film-coated tablets [Accessed on the 22nd of August 2019], Available at:

HealthDirect, 2019, online, Brand name: Zumenon [Accessed on the 22nd of August 2019], Available at:,3030011000036101/zumenon

Patient Leaflet(s)

Affiliated doctors

You know perfectly well what's good and what isn't good for you. Nevertheless, making the right choice can be difficult. We are Dokteronline. We believe in self-management when it comes to your health.

Dr. E. Maescu

MD General practitioner / emergency medicine

Dr. P. Mester

MD General practitioner / internal medicine

Dr. I. Malik

MD General practitioner / general medicine
Back to top