Combodart

Combodart is a medication used for the treatment of BPH. This substance combines two active ingredients, tamsulosin and dutasteride to act on the prostate gland and reduce the risk of side effects. More information

A doctor will review your order and write you a prescription, if appropriate. This prescription is then forwarded to a pharmacy. The pharmacy will have your medicine delivered to you within one to three working days. Read more about this process here.

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Combodart is a medication used to relieve some of the symptoms associated with benign prostatic hyperplasia, or BPH. This substance can also reduce the risk of developing an inability to pass urine that might demand surgery. 

What is Combodart? 

Combodart is a medication used for the treatment of BPH. This substance combines two active ingredients, tamsulosin and dutasteride to act on the prostate gland and reduce the risk of side effects. The prostate gland is only present in men, and it connects the urethra to the bladder. This gland enlarges as men get older, and this can lead to issues with urine flow over time. Combodart helps to overcome those issues, as a kind of alpha blocker. The medication works by blocking the receptors in the prostate gland muscles, causing the muscles to relax, which relieves some of the pressure that might stop urine from flowing freely through the urethra.  

This medication belongs to a specific group of drugs called 5-alpha reductase inhibitors. It works by reducing the impact of the 5-alpha reductase enzyme, which converts the hormone testosterone into a different form of testosterone called DHT. The enlargement of the prostate gland is dependent on the presence of DHT in the male body. When DHT is absent, the muscle shrinks. The combined actions of the muscles relaxing in the prostate gland and the shrinking of the gland itself means that there's less pressure on your urethra and bladder when you're trying to pass urine.  

When is Combodart used? 

It's very common for the prostate gland in men to become larger as you get older. Your doctor won't prescribe Combodart to every man, however. Usually, this substance will only be given to you if you're suffering from something called BPH, or benign prostatic hyperplasia. If you have this condition, you might notice that it's difficult to urinate, or that you can't quite empty your bladder fully when you go to the bathroom.  

Your doctor will prescribe Combodart to block the production of the dihydrotesterone hormone that makes prostate enlargement more likely. Although this medication won't cure the condition completely, it will help to relax the muscles in the prostate and cause the prostate gland to shrink, so you're less likely to experience symptoms.  

If your prostate enlargement issues are particularly bad, then more than one kind of medication might be necessary to deal with your symptoms. That's why Combodart combines the common medication dutasteride with tamsulin, to help you get quicker and better relief from your symptoms then you would be able to accomplish with just one medication alone.  

How do you use Combodart? 

It's important to follow the instructions given by your doctor carefully when using Combodart to make sure that you get the most out of this medication. If you're unsure about anything, read through the printed information included in the patient leaflet within the medication packaging. This will provide additional information about how this substance works, and it will also give you a full list of side effects associated with this drug. If you have any concerns after reading the medication leaflet, contact your doctor or pharmacist. You will need to take this pill exactly as your doctor tells you to do so. Usually, this means taking a single capsule of Combodart once per day. Do not chew or open the capsule - swallow the medication whole with a glass of water with necessary. It's usually a good idea to take Combodart before or after a meal, as this can reduce your risk of nausea and other gastrointestinal issues. Additionally, taking Combodart with a meal will help you to remember to take it at the same time each day. Remember to space your doses evenly to get the best results. If you forget to take a dose at any point during your treatment, you can take it as soon as you remember. If you don't remember to take Combodart until the next day, simply skip the missed dose and carry on as normal. Do not take a double dose of Combodart to make up for a missed capsule.  

What dosages are available? 

Your doctor will tell you how often to take Combodart and how many pills you need to take. Follow those instructions exactly, even if they deviate from the information provided in the patient leaflet. Usually, the dose for Combodart is one capsule taken once per day after or before a meal. If you're concerned that you might have taken more Combodart than necessary, contact a doctor or emergency health professional.  

What are the side effects of Combodart? 

Combodart is considered to be a very safe form of treatment for prostate problems. This means that most people taking this medication won't experience any negative side effects at all. However, like with all medications, there's always a risk that you could encounter symptoms after taking this pill. Remember, you may be more likely to experience side effects when you first begin taking Combodart, as your body will be getting used to the new medication in your system. The list below is not a complete overview of all the side effects that may occur when taking Combodart, make sure that you contact your doctor if you notice any worrying conditions, even if they are not listed here.

Common side effects include: 

  • Breast disorders including enlargement and tenderness 
  • Ejaculation issues including decreased sperm count 
  • Decreased or altered sex drive 
  • Difficulty maintaining or achieving an erection 
  • Dizziness 

Slightly less common side effects may also occur, including a heavier than usual heartbeat, headache, or a reduction in blood pressure that causes you to feel dizzy when you stand up quickly. Inflammation in the lining of the nose can also occur, which leads to runny nose, or blocked nose symptoms. Additionally, some people have gastrointestinal issues like diarrhea, constipation, vomiting or nausea. If you vomit or have diarrhea after taking Combodart, then you might need to contact your doctor about what to do next.  

Weakness or loss of strength may also happen when taking this medication, and in rare cases, hair loss or increased hair growth can occur. Heart failure is a rare but possible side effect. In very severe cases, you may notice swelling of the throat, tongue, or face, which may indicate an allergic reaction. In some circumstances, people have experienced persistent and painful erections, or swelling in the testicles. If you have any side effects that you're worried about, contact your doctor and get their advice on whether you should continue using Combodart. It may be better to try a different medication for your condition.  

When shouldn't you use Combodart? 

Combodart is only suitable for men. However, it will not be the right treatment for all men. You will need to discuss your symptoms and medical condition with your doctor in depth to ensure that this treatment is right for you. Sometimes, a medication will not be suitable if you already have certain conditions. There's also a chance that this medication will only be appropriate to use for you if extra precautions are taken to avoid dangerous side effects.  

Do not take Combodart if you have ever had an allergic reaction to this medication or any similar substances. Do not take this drug if you have or have ever had any problems with the functioning of your liver. It is important to avoid Combodart if you are using any other medications that may interact poorly with Combodart too. This includes medications that have the same active ingredients as Combodart.  

Does Combodart interact with any other medications? 

It's worth telling your pharmacist or doctor what other products you're using before you begin taking Combodart. Some medications can interact poorly with other substances, increasing your chances of dangerous side effects. You will need to tell your doctor about all substances that you might be using before taking Combodart, including any prescription drugs, over-the-counter medications, and supplements. Herbal products can have an impact on your medications too.  

Check with your doctor or pharmacist before you begin using any new medicines when you are already taking this one, to ensure that the new combination is safe. If this medication is taken with medicines that reduce blood pressure, then it's effect may be increased, which means that you're more likely to experience fainting and dizziness. Medications that reduce blood pressure might include vardenafil, or tadalafil. Alpha-blockers can also cause lower blood pressure, as can certain anesthetics. Medications like paroxetine and cimetidine can increase the levels of the active ingredient tamsulosin in your blood after taking Combodart. It is important to make sure that you check with your doctor whether it's safe to take Combodart when using those medications.  

Where can you buy Combodart? 

Combodart is available to buy only from registered pharmacies. Before you purchase Combodart, make sure that you are dealing with a credible EU company. We can arrange to have this medication sent to a local EU pharmacy on your behalf, to collect in your name.  

Can you get Combodart without a prescription?  

It is dangerous to try and take medications like Combodart without a prescription. Your doctor will only provide a prescription after making sure that the substance is safe to use in your circumstances. We can arrange for a consultation with a registered doctor on your behalf. 

 

References 

Drugs.com, online, 2019, COMBODART 0.5MG/0.4MG HARD CAPSULES [Accessed on the 27th of August 2019], Available at:  https://www.drugs.com/uk/combodart-0-5mg-0-4mg-hard-capsules-leaflet.html

Mims, 2019, online,  Combodart [Accessed on the 27th of August 2019], Available at: https://www.mims.co.uk/drugs/genito-urinary-system/bph-urinary-retention/combodart

Steve Chapline, MSc, MrPharms, and Roger Kirby, MA, MD, FRC, FEBU, online, Combodart: combined therapy for moderate to severe BPH [Accessed on the 27th of August 2019], Available at: https://onlinelibrary.wiley.com/doi/pdf/10.1002/psb.661

 

 

Assessed by:

Dr Imran Malik, General practitioner
Registration number: GMC: 4741366

Dr Imran Malik studied undergraduate medicine at King's College University in Central London and clinical studies at the prestigious King's College Hospital. He graduated with a MBBS degree in 2000 and went on to gain postgraduate memberships with the Royal Society of Medicine and also General Practice in 2006.