Epiduo Gel

Epiduo Gel

Epiduo Gel is an acne treatment that you can apply directly to the area that suffers most from acne zits or pimples. The product contains a combination of two separate substances which work together to improve your recovery from acne breakouts and reduce the number of pimples on the skin. More information

A doctor will review your order and write you a prescription, if appropriate. This prescription is then forwarded to a pharmacy. The pharmacy will have your medicine delivered to you within one to three working days. Read more about this process here.

Instruction costs (includes consult & service fee)
Service – Instruction costs (includes consult & service fee)
Patient Leaflet(s)

Epiduo Gel is an acne medication that's applied topically to the skin in a cream or gel form. The medication includes two active ingredients, adapalene, and benzoyl peroxide. Adapalene is a retinoid which affects the way that the cells grow, reducing inflammation and swelling. On the other hand, Benzoyl Peroxide is skin-peeling agent and antibiotic that works to causing dead skin to dry and peel away. Together, the two substances may decrease the severity and number of acne pimples on the skin.

What is Epiduo Gel? 

Epiduo Gel is an acne treatment that you can apply directly to the area that suffers most from acne zits or pimples. The product contains a combination of two separate substances which work together to improve your recovery from acne breakouts and reduce the number of pimples on the skin.  

The first ingredient in Epiduo Gel is Adapalene, which is a lot like vitamin A, as it helps the skin to heal and renew itself. It's great at improving the turnover of cells, which means that you get rid of damaged skin quicker. Additionally, Adapalene has an anti-inflammatory impact on the skin, which reduces swelling and redness to make spots less noticeable.  

The second ingredient, Benzoyl Peroxide, is particularly effective at killing bacteria on the skin, which reduces your risk of developing additional spots. The substance exfoliates the surface layer of the skin, unblocking the pores and allowing the sebaceous glands to work naturally. Benzoyl Peroxide also has a mild drying effect, which means that it helps to get rid of old skin cells, and lets you wash away bacteria and excess oils more easily.  

Together, Epiduo Gel helps to eliminate some of the most common forms of acne; particularly in teenagers and young adults. It's excellent for reducing the risks of impending spots too.  

When is Epiduo Gel used? 

Epiduo Gel will often be offered as a prescription solution for people who suffer from very painful or uncomfortable acne. Usually, this medication is a treatment that's best-suited for people who feel as though they can't control their acne by themselves. It's suitable for most people over the age of 9 and can be used on various parts of the body, although a doctor will often provide insights into how this medication should and should not be used. 

Although Epiduo Gel will begin to get to work on reducing acne from the moment that it is applied, it's important to remember that you might not see the difference for a few weeks. Most people will need to continue using Epiduo Gel for a period of at least a couple of months before their condition will significantly improve.  

How do you use Epiduo Gel? 

Getting the best results from Epiduo Gel requires patience and persistence. Your doctor will tell you how often to apply this serum, and where you should avoid placing it on your skin. Before you apply Epiduo Gel, make sure that you wash your hands and the affected area with a mild cleanser and pat the skin dry. You can then apply a very thin layer of medication to the affected skin as directed by your doctor.  

It is important to use Epiduo Gel only on the outer skin, and not on any inner lip areas, in the mouth or nose, or on any mucous membranes. Epiduo Gel cannot be applied to any sunburned or scraped skin, so make sure you speak to your doctor if you have any open wounds. When applying Epiduo Gel, make sure that you avoid getting it into your eyes. If you accidentally rub your eyes after using Epiduo Gel, flush them out with large amounts of water, and contact a doctor if you start to notice irritation or blurred vision.  

Your treatment plan for Epiduo Gel will be dependent on the nature of your condition and how well you respond to treatment. When you first start using Epiduo Gel, you might find that your condition seems to worsen for a few weeks, as the substance will be working on the spots that are forming on the outer layer of skin. It's important to continue using Epiduo Gel, following the instructions of your doctor, even if you think that it isn't working properly.  

Do not use a larger amount of Epiduo Gel than necessary, as this will not speed up your ability to eliminate spots, and make sure that you contact your doctor if your condition worsens or persists.  

What dosages are available? 

Epiduo Gel is applied once a day in most cases, although your doctor may ask you to adjust your dosage depending on your response to treatment. Apply about a pea sized amount to each area of the face, such as the chin, forehead, and cheek. You can also apply Epiduo Gel to the trunk and bank. Do not apply around the eyes, and lips.  

What are the side effects of Epiduo Gel? 

Most of the people who use Epiduo Gel will not notice any significant side effects. However, if you do find that negative symptoms occur when you begin using this product, you can talk to your doctor about your options. You may need to switch to a different form of treatment.  

The most common responses to Epiduo Gel is that your acne might get worse for the first four weeks that you're using the product. However, this will pass, and it could be a sign that the treatment is working. Additionally, you may notice some significant dryness in your skin, or a mild sensation of peeling or burning when you're applying the gel. Your doctor might want you to use a moisturizer with Epiduo Gel to counteract some of the drying effect.  If you notice any of the symptoms above, or you feel as though your skin is swelling or stinging and the issue persists, speak to your doctor. You should also contact your doctor if you notice any other side effects that aren't mentioned here.  

In some cases, people using Epiduo Gel, might notice that their skin becomes scalier or more red at the application site. However, these issues will often pass by themselves. A very significant allergic reaction to Epiduo Ge is rare. However, you should seek emergency medical help if you notice swelling in the face throat or tongue, trouble breathing, or severe dizziness.  

Use caution when applying Epiduo Gel to your skin near the hairline, as it could bleach your skin, hair, and clothing.  

When shouldn't you use Epiduo Gel? 

Before you begin using Epiduo Gel, it's a good idea to talk to your doctor or pharmacist about any existing medications that you're using, and any allergies that you have. If you are allergic to benzoyl peroxide, adapalene, or any vitamin A drugs, then you might not be suitable for using Epiduo Gel.  

In some cases, Epiduo Gel may make you more sensitive to the sun. With that in mind, it's important to limit your exposure to the sun and avoid any sun lamps or tanning booths when using this product. You can also use protective clothing and sunscreen to defend yourself against the sun when you're outdoors. Speak to your doctor if you get any burns that lead to blisters. Wait until you recover from a sunburn before you continue to use Epiduo Gel. Avoid any chemical hair removal products, electrolysis, or waxing on the areas of skin that you want to treat with Epiduo Gel. Because this drug is absorbed through the skin, it may affect women who are pregnant or people who are trying to become pregnant. It is uncertain whether this drug is harmful to women who are breastfeeding.  

Does Epiduo Gel interact with any other medications? 

Most topical treatments, including acne treatments like Epiduo Gel will not have any significant interactions with other medications that are given orally or intravenously. However, it's important to remember that drugs can still interact with each other in many different ways. To reduce your risk of any dangerous interactions, it's important to speak to your healthcare providers about any of the medicines you regularly use, including over-the-counter drugs and prescription medications. Be sure to mention supplements and herbal products too.  

You should not use Epiduo Gel alongside other products that are classed as retinoids, or products that contain benzoyl peroxide as an active ingredient as this may cause your skin to become overly dry. It is also best to avoid using strong peeling agents like glycolic acid or salicylic acid with Epiduo Gel. Strong drying agents and acne products containing astringents and alcohols are not suitable to use with Epiduo Gel.  

Where can you buy Epiduo Gel? 

Epiduo Gel is available to purchase online and in pharmacies around the world today. However, it is important that you have a full consultation with a doctor before you attempt to buy this product. Remember that there are many different kinds of acne treatment, and Epiduo Gel might not be right for you.  

Can you get Epiduo Gel without a prescription?  

In the UK Epiduo Gel is not available to purchase without a prescription. Your doctor will need to assess your medical history and condition before giving you this medication to ensure that you are receiving the right treatment. Make sure that you book a consultation with a medical professional so that you can get a dose of Epiduo Gel.  




Angela Palmer, 15th of March 2019, Verywell Health, Online, Treating acne with Epiduo Gel, [Accessed on 26th of June 2019], Available on: https://www.verywellhealth.com/information-on-epiduo-acne-treatment-15878  

eMedicine Health, Adapalene and Benzoyl Peroxide Topical, Online, [Accessed on 26th of June 2019], Available on: https://www.emedicinehealth.com/drug-adapalene_and_benzoyl_peroxide_topical/article_em.htm  

John P. Cunha, DO, FACOEP, RXlist, online, 2018, Epiduo side effects, drug centre, [Accessed on 26th of June 2019], Available on: https://www.rxlist.com/epiduo-side-effects-drug-center.htm  

Assessed by:

Dr Imran Malik, General practitioner
Registration number: GMC: 4741365

Dr Imran Malik studied undergraduate medicine at King's College University in Central London and clinical studies at the prestigious King's College Hospital. He graduated with a MBBS degree in 2000 and went on to gain postgraduate memberships with the Royal Society of Medicine and also General Practice in 2006.