Indivina is a form of medication in the hormone replacement therapy family, otherwise known as HRT medication. This kind of medicine is used to tackle the common symptoms that occur during various phases of the menopause, when a woman's oestrogen levels begin to diminish with age. When the oestrogen levels in a woman's body fall, the result can be night sweats, hot flushes, irregular periods, vaginal dryness, mood swings, and other side effects. The oestrogen substance in Indivina, estradiol helps to replace the reduced levels of oestrogen in the body. However, to reduce the risk of an increased threat of cancer caused by the thickening lining of the womb, a dose of progesterone is also needed. In this case, medroxyprogesterone is used as a replacement for the natural progesterone substance. In women who have had their womb removed through a hysterectomy, it is not necessary to have progesterone as well as oestrogen in an HRT treatment.
Indivina tablets are a form of hormone replacement therapy containing the active ingredient Estradiol, otherwise known as oestradiol in some parts of the UK. The other active ingredient of Indivina is Medroxyprogesterone. These two substances combined together are used to overcome some of the more common symptoms of the menopause.
What is Indivina?
Indivina is a form of medication in the hormone replacement therapy family, otherwise known as HRT medication. This kind of medicine is used to tackle the common symptoms that occur during various phases of the menopause, when a woman’s oestrogen levels begin to diminish with age. When the oestrogen levels in a woman’s body fall, the result can be night sweats, hot flushes, irregular periods, vaginal dryness, mood swings, and other side effects. The oestrogen substance in Indivina, estradiol helps to replace the reduced levels of oestrogen in the body. However, to reduce the risk of an increased threat of cancer caused by the thickening lining of the womb, a dose of progesterone is also needed. In this case, medroxyprogesterone is used as a replacement for the natural progesterone substance. In women who have had their womb removed through a hysterectomy, it is not necessary to have progesterone as well as oestrogen in an HRT treatment.
When is Indivina used?
Indivina is just one of the many forms of HRT available for women who have not had a hysterectomy following the beginning of menopause. The Indivina tablet is a continuous form of combined hormone replacement therapy, where the female body is consistently exposed to the same dose of oestrogen and progesterone every day. This type of HRT doesn’t lead to a monthly bleed similar to other treatments.
Doctors will typically only prescribe Indivina to women who have already stopped having regular periods. It is unlikely that you will be given this medication unless you haven’t had a period for three years or longer. In many cases, the reduction of oestrogen in the female body can also lead to increased issues with things like bone loss and osteoporosis in women. Because postmenopausal women are more likely to suffer from osteoporosis, Indivina can be used as a treatment to protect against this problem, and also reduce the risk of fractures as the bones start to become fragile, brittle, and more prone to breaking. When you begin taking Indivina, your doctor will ask you to commit to regular medical checkups to ensure that you are not having any negative reactions to the substance.
How do you use Indivina?
Indivina is a continuous form of hormone replacement therapy. This means that you will usually be asked to take a single tablet once a day for a long period of time. You will not need to take any breaks between packets of Indivina as you would with a contraceptive pill. However, it’s important to remember that regular checkups are necessary with Indivina. Your doctor will review whether you should continue taking this substance after a year.
Indivina can be taken by mouth with a glass of water or another non-alcoholic drink. These tablets can be taken with or without food, although some people find that it is easier to take them with food, as this will remind them when to take their tablet each day. Similarly, to the contraceptive pill, it’s important to take Indivina at the same time each day whenever possible, as this will improve the effectiveness of the medication. If possible, set an alarm that will remind you to take your dose on time.
What dosages are available?
Only one dose of Indivina is available on the market today, and it contains 2.5 mgs of the combined hormonal substances used control your menopausal symptoms. For most women on Indivina you will be asked to take one tablet each day continuously, although your doctor might adjust your medication strategy according to the way that your body responds.
If you forget to take your daily dose of Indivina at the time you would usually take it, it’s important not to double up. You can simply leave your forgotten dose out and take the next dose as usual. If you concerned about missing a dose, or if you have vomiting or diarrhea soon after taking Indivina speak to your doctor about your options.
What are the side effects of Indivina?
All hormone replacement therapy treatments, including Indivina can have side effects. This substance may affect different people in unique ways, so it’s important to remember that the following list might not include all of the symptoms that you may feel. If you notice anything unusual about the way you feel when taking Indivina, stop taking the medicine and contact your doctor immediately.
Some side effects that may occur when taking Indivina include:
- Breast enlargement, tenderness, or pain
- Nausea and vomiting
- Abdominal pain or bloating
- Indigestion and flatulence
- Menstrual spitting or bleeding
- Migraine or headaches
- Fluid retention and swelling
- Increased size of uterine fibroids
- Premenstrual symptoms such as mood swings and pain
- Mood changes like irritability, anxiety and depression
- Changes in sex drive
- Fatigue and dizziness
- Sudden weight changes
- Rises in blood pressure
- Leg cramps
- Changes in the corneal curvature which may make it difficult to wear contact lenses
- Skin reactions like itching and rash
Some women taking Indivina notice brown patches of skin – usually around their face. There are also some more serious side effects that can occur as a result of taking Indivina, including an increased risk of gallbladder disease, or inflammation of the pancreas. Some women who take Indivina will also be more likely to experience blood clots, which can lead to heart attacks, strokes and pulmonary embolism.
If you notice any changes in your liver function which lead to yellowing of the skin or eyes, contact a doctor immediately. Make sure you seek emergency medical attention if you notice signs of an allergic reaction, such as trouble breathing, or swelling around the throat, face, or tongue.
When shouldn't you use Indivina?
Many women will be able to use Indivina safely without any negative side effects. Women with suspected or known history of breast cancer or cancer where the issue might be stimulated by the presence of additional oestrogen should also avoid taking Indivina. If you have an untreated overgrowth in your womb lining, this will not be the right medicine for you, additionally, women with blood disorders that increase their risk of clotting may be at greater risk when taking Indivina.
Your doctor will usually not prescribe Indivina if you have conditions such as:
- Vaginal bleeding where the cause is not known
- Inflammation of veins caused by blood clots
- Blood clots deep in the vein of the leg
- Blood clots in the lungs
- Previous instances of stroke, heart attack, or angina
- Liver disease or history of liver problems where liver function has not returned to normal
- Inherited blood disorders
If you are pregnant or breastfeeding, you should not be taking Indivina. Additionally, it may not be appropriate to take this medication if you have a galactose intolerance, or a problem with glucose-galactose malabsorption.
Does Indivina interact with any other medications?
If you have any allergies to any of the substances in Indivina make sure that your doctor is aware of this before you begin using the medication. Before taking any new treatment for hormone replacement therapy, it’s important to have a discussion with your doctor that covers your complete medical history and the medical history of your family.
You will also need to talk to your doctor about any medicines you’re taking besides Indivina as there can be interactions between various different kinds of drugs. This will include mentioning any herbal remedies or supplements that you’re taking, alongside prescription medications and medicines that you can buy over the counter.
Some of the medicines that might interact negatively with Indivina include:
- Drugs used for the treatment of epilepsy and fits such as carbamazepine and phenytoin
- Drugs used for the treatment of tuberculosis such as rifabutin and rifampicin
- Drugs used for the treatment of HIV infections such as ritonavir and nevirapine
- Drugs used with the herbal substance St John’s Wort
In some cases, taking Indivina can also affect the way that drugs used for the treatment of diabetes work. Your doctor will ask you to take regular readings of your blood glucose levels to make sure that you do not need to adjust your treatment when taking Indivina. Additionally, it’s possible for the drug Indivina to interact negatively with substances used to reduce blood pressure. Usually, when you’re given a hormone replacement therapy by your doctor, they will ask you to commit to regular blood pressure tests, as well as general medical reviews to ensure that none of your medications are interacting poorly. Your doctor will assess the risks of prescribing Indivina to you if you are taking any other medications carefully.
Where can you buy Indivina?
It is possible to buy hormone replacement therapy pills and substances like Indivina online or offline from an authorised pharmacy. Remember that Indivina is a treatment that can only be prescribed by a doctor. You should never purchase this substance from a store that promises to give it to you without a doctor’s prescription, as this could be very dangerous.
Can you get Indivina without a prescription?
All treatments for hormone replacement therapy require a prescription from your doctor. Only your doctor will be able to assess your medical condition and medical history to ensure that Indivina is the right treatment for you. You should not try to purchase or use Indivina without a prescription, as it could react dangerously with other medications, or may not be suitable for your condition.
NICE, 2018, Indivina Tablets online, [Accessed on the 19th of June 2019], Available On: https://bnf.nice.org.uk/clinical-medicinal-product-information/indivina-tablets.html
Orion Corporation, 2018, Indivina 1mg/5mg tablets, Online [Accessed on the 19th of June 2019], Available on: https://www.medicines.org.uk/emc/product/4066/pil