Kliofem is a hormone replacement therapy (HRT) preparation for women. Kliofem tablets contain two ingredients: estradiol (an oestrogen hormone) and norethisterone (a progestogen hormone). More information

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Kliofem 2 mg 84 tabl. + Consultation + Service fee

Patient Leaflet(s)

What is Kliofem?

Kliofem is a hormone replacement therapy (HRT) preparation for women. Kliofem tablets contain two ingredients: estradiol (an oestrogen hormone) and norethisterone (a progestogen hormone). As women reach menopause their bodies produce less and less oestrogen. These declining levels can cause distressing symptoms. Kliofem supplements hormone deficiencies and restores hormonal balance in women going through menopause.

What is Kliofem used for?

Kliofem relieves menopausal symptoms such as hot flashes, night sweats, mood swings, sleeping difficulties, dryness of the mucous membranes and osteoporosis. It is usually used to treat women experiencing a natural menopause who have not had a period in more than 12 months and who have not had a hysterectomy, and women who have had their ovaries removed. The added ingredient in Kliofem, norethisterone, protects the lining of the uterus from side effects.

How to use Kliofem

Kliofem tablets should be taken at the same time each day with some water. They can be taken with or without food. Kliofem is available in convenient blister calendar packs marked with the days of the week. Each strip contains 28 tablets, which should be taken back to back without a tablet-free interval. This means Kliofem does not produce a withdrawal bleed. You will need to talk with your doctor if you want to use this medicine daily for more than two years.


Unless otherwise advised by the doctor, the usual dose in adults is:

  • one tablet once daily.

Always follow the prescription exactly – never take more or less than the doctor recommends. Read the package leaflet closely before use.

Side effects

Side effects that are known to be associated with Kliofem include:

  • Headache;
  • Breast tenderness or soreness;
  • Gastrointestinal symptoms such as stomach ache, nausea or diarrhoea;
  • Breakthrough bleeding, increase in vaginal discharge;
  • Fluid retention.

Consult a doctor if these or other side effects are severe. For more information, see the package leaflet. It is important to be aware that all women using HRT have a slightly increased risk of being diagnosed with cancer and thrombosis compared with women who don't use HRT. For more information, see the package leaflet.

When not to use Kliofem

Kliofem is not suitable for everyone and should not be used if:

  • You are allergic to estradiol, norethisterone or any other ingredient in this medicine;
  • You have a known or past history of breast cancer, cancer of the lining of the womb (endometrial cancer) or any other oestrogen-related cancer;
  • You have a condition affecting the lining of the womb;
  • You have a known or past history of blood clots in the veins (thrombosis) or certain blood, heart or vascular disorders;
  • You have a liver condition.

Consult a doctor on the use of Kliofem if you have a health condition that is not listed above or are currently on medication. For a complete list of contraindications, interactions and warnings, see the package leaflet.

Pregnancy/driving ability/alcohol

Kliofem is usually given to women who are no longer in the fertile age bracket. For women who don't fall within this group: Kliofem should not be used if you are pregnant, planning to conceive or breastfeeding. Caution: Kliofem is not a contraceptive pill and will not prevent pregnancy! If you are under 50 or it has not been a year since your last menstrual period, you should use some form of contraception as a precaution. This medicine does not interact with alcohol or affect your ability to drive safely.