Loceryl is a nail lacquer that kills fungi on the nail. It contains the active ingredient amorolfine (as the hydrochloride) which is part of a group of drugs called antifungals. It can kill a wide variety of fungi that cause nail infections. More information

A doctor will review your order and write you a prescription, if appropriate. This prescription is then forwarded to a pharmacy. The pharmacy will have your medicine delivered to you within one to three working days. Read more about this process here.

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A fungal nail infection is something that may affect up to 70% of the population in their lifetime, so it is not uncommon. They are often contracted at saunas or swimming pools or anywhere else where you may walk around on the damp ground with bare feet, although they can also be caused by a weakened immune system or wearing shoes that don’t allow your feet to breathe. Essentially the cause is warmth combined with damp. Fungal nail infections can take a long time to go away and look rather unpleasant, although if there are no complications it isn’t a serious illness and you can usually cure it at home over time. If you have a weakened immune system or are diabetic then a fungal nail infection could cause more serious issues. 

What is Loceryl? 

Loceryl is a nail lacquer that kills fungi on the nail. It contains the active ingredient amorolfine (as the hydrochloride) which is part of a group of drugs called antifungals. It can kill a wide variety of fungi that cause nail infections

The other ingredients in Loceryl are methacrylic acid copolymer, glycerol triacetate, butyl acetate, ethyl acetate and absolute ethanol. 

Loceryl comes in a bottle and in the pack, alongside the bottle, you’ll find cleansing swabs, nail files and either a spatula integrated into the cap or a separate spatula to help you use the product properly.  

The lacquer is applied directly to the affected nail or nails which means that the active ingredient can penetrate easily, right to the spot where it is needed to attack the fungus and kill it.  

As nails are hard and take a long time to grow this makes treating a fungal nail infection tricky, this is why you’ll need to use the nail files to help Loceryl get to the source of the infection so that it can penetrate the cell membranes that are causing the infection and make them break down and die. 

When is Loceryl used? 

Loceryl is used to treat fungal nail infections, it can be used on both fingernails and toenails. Loceryl can treat a wide variety of fungi that cause nail infections. 

Points to note with regards to fungal nail infections: 

  • An easy to spot sign of an infection is discolouring of the nail, it will turn yellow, brown or white; 
  • The infection usually starts at the edges of the nail and spreads towards the middle of the nail; 
  • Your infected nail will also start to thicken; 
  • The nail will then become brittle and crack or crumble easily; 
  • The root of the infection is in the nail bed so treatment can take a while as it is hard for anything applied over the nail to reach the source of the infection; 
  • If left untreated the infection can also cause swelling, pain and itching around the nail. 
  • Leaving athlete’s foot untreated can lead to a fungal nail infection; 
  • Fungal nail infections are often contracted in warm, damp places like public swimming pools or saunas so wearing flip-flops or a special sock may help to prevent them, or prevent spreading them if you have it yourself. 
  • Fungal nail infections are contagious so always ensure you keep your feet clean by washing them with soap and never share a towel or nail clippers to prevent the infection spreading to other members of your family. 

How do you use Loceryl? 

Always use Loceryl exactly as you are instructed to by your doctor or pharmacist if you are unsure then check before starting to use Loceryl. 

Loceryl should be applied directly to the affected finger or toenail. 

Before you start, check you have everything you need from the pack, nail file, cleansing swab, applicator and bottle of Loceryl nail lacquer; 

To begin, take one of the files in the pack, and use it to file down the infected areas of the nail or nails, including the nail surface; 

Never use nail files used for infected nails on healthy nails as there is a risk of infection; 

  • Never share the nail files from your kit to prevent the spread of infection; 
  • Once you have done this, remove one of the swabs from your pack; 
  • Use the swab to clean the nail carefully; 
  • You should file and then clean each infected nail separately; 
  • When you have finished filing and cleaning the nails, take the applicator and, taking care not to wipe it on the edge of the bottle, dip it into the bottle of Loceryl; 
  • Then apply the nail lacquer evenly over the surface on any infected nails; 
  • Try to avoid getting the lacquer on the skin around the nail as this could lead to irritation; 
  • Leave the nail to dry in the open air for around three minutes before covering; 
  • If you want to apply cosmetic nail varnish on top then wait at least 10 minutes after applying Loceryl; 
  • Once you have finished, clean the applicator thoroughly before putting it away for next time. You can use the same swab you used to cleanse the nails, keep the swab away from newly treated nails; 
  • Ensure you close the bottle tightly and dispose of the swab carefully when you are done as it is inflammable; 
  • You will need to repeat this process once or twice a week; 
  • Before using Loceryl again, remove any old lacquer and nail varnish; 
  • Once Loceryl lacquer has dried it will not be affected by soap and water, so you can wash your hands and feet as normal; 
  • If you are using any type of cleaning product or chemical then you will need to wear rubber gloves/cover your toenails; 
  • Continue using Loceryl once or twice a week until the infection has completely cleared and new healthy nails have grown back; 
  • This takes around 6 months for fingernails and 9 to 12 months for toenails; 
  • Do not be disheartened if there are no visible improvements, a nail only grows by 2mm a month; 
  • After 6 months improvement should be seen in 70 to 80% of people. 

What dosages are there? 

Loceryl contains 5% amorolfine. It comes in a pack size of either 2.5ml, 5ml, 7.5ml or 10ml bottles. 

You should apply Loceryl to the affected finger or toenails once or twice a week as directed by your doctor or pharmacist; 

  • Continue this weekly or bi-weekly application until a new healthy nail has grown back (6-12 months). 

If you forget to apply the lacquer on your usual day then just start the process on the first day that you remember to do it. 

What are the side effects of Loceryl? 

As with all medication, Loceryl comes with a warning of some side effects, though not everyone who uses Loceryl will experience them. 

Loceryl can cause serious allergic reactions, seek urgent medical assistance if you experience any of the following. 

  • Difficulty breathing; 
  • Swelling around the face, lips, tongue or throat; 
  • A severe skin rash. 

Loceryl can also cause short term skin irritation around the infected nail, be extra careful not to paint the lacquer onto your skin to help prevent this. 

In rare cases (up to 1 in 1,000 people) you may experience the following: 

  • Damage to the nail; 
  • Nail discolouration; 
  • Fragile or brittle nails. 

In extremely rare cases (1 in 10,000 people) you may experience a burning sensation on your skin, remember to avoid the skin around your nail when applying the lacquer. 

When shouldn’t you use Product name? 

Although Loceryl does not have many side effects compared to some medication there are still some cases when you cannot use it. 

Loceryl should not be used by children under 12; 

  • You should not use Loceryl if you are pregnant or breastfeeding or planning a pregnancy unless this is under the guidance of a qualified medical professional; 
  • Do not use Loceryl if you are allergic to amorolfine or any of the other ingredients listed on the packet. 

Does Loceryl interact with other medications? 

Loceryl has no known interactions with other medications. That said, it is still worth mentioning any medication or treatment you are following when talking to your doctor or pharmacist. 

Loceryl is not compatible with artificial nails, but you can use cosmetic nail polish once the lacquer has dried. Wait at least 10 minutes after applying Loceryl before applying cosmetic nail polish. 

Where can you buy Loceryl? 

Loceryl is available from any reputable pharmacy, so purchase it wherever is most convenient for you. It might be online so you can have it delivered to your door or you may prefer to pick it up at the pharmacy in your supermarket next time you are there. The choice is yours 

Can I get Loceryl without a prescription? 

Yes. Loceryl is available without a prescription, you can buy it over the counter at the pharmacy. You may wish to speak to the pharmacist for advice or chat to your doctor if you have underlying conditions or are pregnant or breastfeeding. You may also wish to have your doctor monitor the progress of the treatment. 


Centre for Disease Control and Prevention (2017). Fungal Nail Infections | Fungal Diseases | CDC. [online] Cdc.gov. Available at: https://www.cdc.gov/fungal/nail-infections.html [Accessed 27 Nov. 2019]. 

Galderma (2018). Loceryl Nail Lacquer. [online] NPS MedicineWise. Available at: https://www.nps.org.au/medicine-finder/loceryl-nail-lacquer [Accessed 18 Dec. 2019]. 

Galderma (2017). [online] Medicines.org.uk. Available at: https://www.medicines.org.uk/emc/files/pil.1411.pdf [Accessed 18 Dec. 2019]. 

NHS (2017). Fungal nail infection. [online] nhs.uk. Available at: https://www.nhs.uk/conditions/Fungal-nail-infection/ [Accessed 18 Dec. 2019]. 

NICE (2018). Fungal skin infection - foot - NICE CKS. [online] Cks.nice.org.uk. Available at: https://cks.nice.org.uk/fungal-skin-infection-foot#!scenario [Accessed 27 Nov. 2019]. 

Assessed by:

Dr Imran Malik, General practitioner
Registration number: GMC: 4741365

Dr Imran Malik studied undergraduate medicine at King's College University in Central London and clinical studies at the prestigious King's College Hospital. He graduated with a MBBS degree in 2000 and went on to gain postgraduate memberships with the Royal Society of Medicine and also General Practice in 2006.