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Pro-banthine is a form of anti-spasmodic medication designed to reduce the spasming and pain in the muscles throughout the bladder and gut. Using the active ingredient propantheline, Pro-banthine can relax a specific kind of muscle in the stomach called “smooth muscle”. More information

A doctor will review your order and write you a prescription, if appropriate. This prescription is then forwarded to a pharmacy. The pharmacy will have your medicine delivered to you within one to three working days. Read more about this process here.

Patient Leaflet(s)

Pro-banthine is a tablet prescribed to people with muscle spasm issues in the bladder and gut. This medication contains the active ingredient propantheline, which is a substance that helps to relax the smooth muscle in the body to reduce issues like pain, excessive sweating and even involuntary urination.  

What is Pro-banthine? 

Pro-banthine is a form of anti-spasmodic medication designed to reduce the spasming and pain in the muscles throughout the bladder and gut. Using the active ingredient propantheline, Pro-banthine can relax a specific kind of muscle in the stomach called “smooth muscle”. As a secondary effect, Pro-banthine can also reduce excessive and involuntary sweating.  

Pro-banthine is a form of prescription-only medication that should not be taken without a medical consultation. This treatment is intended for a wide range of conditions, but it will not be suitable for all patients. If Pro-banthine is not right for you, then your consultant may be able to suggest an alternative.  

When is Pro-banthine used? 

Pro-banthine can either be used on its own or in combination with other medications for the treatment of a number of conditions. The substance works by relaxing the smooth muscle in the gut and bladder to treat disorders caused by muscle spasms, such as irritable bowel system and incontinence or involuntary urination. The Pro-banthine active ingredient, propantheline can also reduce secretions like sweat, which means that it may also be used for the treatment of a medical condition called hyperhidrosis.  

People with hyperhidrosis often sweat unpredictably and uncontrollably from their feet, palms, underarms and other areas. This condition may make it harder for a person to exercise. Pro-banthine can also be prescribed for people who have sweating issues after drinking or eating. Gustatory sweating is often associated with conditions such as diabetes. Pro-banthine can work alongside other medications to treat peptic ulcers and reduce the release of acid in the stomach. In certain cases, your doctor may also prescribe Pro-banthine to prevent bed wetting or enuresis in adults.  

How do you use Pro-banthine? 

Before starting any new treatment, make sure that you read the instructions that are printed on the manufacturer’s label inside of the packet. Check the instructions when getting each new packet of pills in case anything has changed since your last treatment. The patient leaflet in your medication will also provide you with more information about the side effects that can occur when taking Pro-banthine and what you can do about them.  

Take the advice given by your consultant into account when using Pro-banthine. It is common to take this medication on an empty stomach, usually either one hour before you eat a meal, or two hours after. You will need to swallow the tablets provided with a glass of water. Ensuring that you don’t eat at the same time as taking this medication will mean that your body can absorb as much of the active ingredient as possible. The medicine will not be as effective when taken with food.  

Take Pro-banthine at the same time each day according to the instructions provided to you. If you forget to take a dose for any reason, do not take a double dose to make up for the missed pill. Follow up with your next dose the next time it is due.  

What dosages are there? 

You will be given a dosage of Pro-banthine based on the condition that you are treating and the severity of your symptoms. The most common dosage is one tablet, taken three times a day during the day. You will also need to take two tablets at once when you’re going to bed. This is the typical dose at the start of your treatment. However, you may need to later increase your dose to a maximum of up to eight tablets per day.  

Each tablet of Pro-banthine contains 15mg of Propantheline. You will need to ensure that you only take this medication for as long as you are prescribed.  

What are the side effects of Pro-banthine? 

While serious side effects with Pro-banthine are not common, it’s important to note that all medications can sometimes cause unexpected results. More often than not, the more common side effects of Pro-banthine will happen when you first begin to use the medication, and your body is still getting used to the new substance. The most common symptoms of Pro-banthine are dry mouth, decreased ability to sweat, and dizziness. Some people taking Pro-banthine will experience widened pupils, blurred vision, vomiting and nausea, or even constipation.  

While the side effects outlined above shouldn’t be dangerous, it’s important to contact a medical professional if you’re concerned that your situation is getting worse, or the effects persist for an extended period of time.  

In rare cases, Pro-banthine may also cause some more severe side effects, including: 

  • Sudden and unpredictable changes in your mood or mental state; 
  • Pain or uncomfortable pressure in the eyes; 
  • A fast or erratic heartbeat; 
  • Difficulty with urination that persists for more than a day. 

Tell your doctor if you experience any of the side effects above, or if you notice any symptoms after taking Pro-banthine tablets that make you feel nervous or uncomfortable. This is not a complete list of possible side effects. 

It is rare for patients to experience a serious allergic reaction when taking Pro-banthine, however you should seek immediate medical attention at a hospital or healthcare facility if you notice signs of an allergic response. You may be having an allergic reaction if you suddenly have an unexpected rash, itching or discomfort at after taking the tablet, or swelling in the throat, face or tongue. Contact a doctor immediately if you have any trouble with breathing or severe feelings of dizziness.  

When shouldn't you use Pro-banthine? 

Pro-banthine is only available on prescription because some people will not be able to take this medication due to issues with medications that they’re already taking, or problems in the medical history. It is important to answer all of the questions asked by your consultant truthfully when you are getting this medication. Make sure your consultant is aware if you are allergic to anything in this substance, including any inactive ingredients.  

Before using this medication, tell your consultant about the details of your medical history, particularly if you have any history of glaucoma or a condition called myasthenia gravis. It may not be appropriate for you to take this medication if you have had disorders caused by blockages in the stomach or bowel, or difficult urinating in the past.  

Avoid using Pro-banthine if you have ever had or are currently suffering from: 

  • Problems with your esophagus like GERD; 
  • Nerve disorders like neuropathy; 
  • Breathing problems; 
  • Ulcerative colitis; 
  • Diarrhea; 
  • Congestive heart failure; 
  • Heart or blood vessel diseases; 
  • High blood pressure; 
  • Kidney disease; 
  • Liver disease; 
  • An overactive thyroid. 

This medication can cause some people to feel dizzy, drowsy, or as if they’re unable to see as well as usual. Taking other substances like alcohol can worsen these side effects and make it harder to complete everyday tasks. Limit your exposure to alcoholic beverages when using Pro-banthine, and make sure that you don’t engage in any dangerous activities when using this substance.  

It may not be suitable to use Pro-banthine when you are pregnant or breastfeeding unless your doctor or consultant advises otherwise. Make sure that any dentists or doctors performing procedures on you know that you are taking Pro-banthine before a treatment begins.  

This medication actively causes a reduction in your ability to produce sweat. The body uses sweating as a way to manage temperature. To prevent heatstroke and other temperature-based issues, make sure that you do not allow yourself to become overheated during strenuous activities, in hot weather, or during exercise. Caution should be advised for people who are using this medication over the age of 60, as they are more likely to be sensitive to the side effects.  

Does Pro-banthine interact with any other medications? 

Interactions between different medications can cause one or the other medication to react differently or act unusually when in your system. It’s important that your consultant knows about any other medications that you are taking before you apply for a Pro-banthine prescription. Remember that you will need to let your consultant know about herbal medications and supplements as well as over-the-counter medications and prescription drugs.  

Antispasmodic medications similar to Pro-banthine may react poorly with this medication. You should also avoid antiarrhythmic drugs like quinidine and drugs that are intended for the treatment of Parkinson’s disease.  

Other medications that may not be suitable for use with Pro-banthine include: 

  • Corticosteroids like prednisone; 
  • Belladonna alkaloids; 
  • Digoxin;Nitrofurantoin, paracetamol, nefopam; 
  • Drugs that require stomach acidity; 
  • MAO inhibitors like procarbazine; 
  • Phenothiazines; disopyramide, antipsychotics, amantadine 
  • Potassium capsules or tablets; 
  • Tricylic antidepressants; domperidone, metoclopramide 
  • Pramlintide. 

Ensure that your consultant is aware if you are taking other products that may make you more likely to suffer from side effects like drowsiness. These substances may include opioid pain relievers like codeine, and drugs for anxiety or sleep. It may not be suitable for you to take Pro-banthine if you are using muscle relaxants or antihistamines at the same time.  

Where can you buy Pro-banthine? 

You can only buy this product at a pharmacy. 

Can you get Pro-banthine without a prescription?  

Pro-banthine and other medications similar to it will not be available without a prescription or medical consultation. 

Sources, online, 2019, "Pro-Banthine", [Accessed 20th of November 2019] Available on: 

EMC, online, 2019, “Pro-Banthine tablets” [Accessed 20th of November 2019] Available on: 

Nice, online, 2019  “Propantheline Bromide” [Accessed 20th of November 2019] Available on: 

Assessed by:

Dr Imran Malik, General practitioner
Registration number: GMC: 4741365

Dr Imran Malik studied undergraduate medicine at King's College University in Central London and clinical studies at the prestigious King's College Hospital. He graduated with a MBBS degree in 2000 and went on to gain postgraduate memberships with the Royal Society of Medicine and also General Practice in 2006.