Treclin is a medicated gel that contains two different active ingredients, Clindamycin and Tretinoin.  It contains 1% Clindamycin and 0.025% Tretinoin.  Tretinoin helps skin to regenerate normally, shedding dead cells so that they do not block the hair follicles. More information

A doctor will review your order and write you a prescription, if appropriate. This prescription is then forwarded to a pharmacy. The pharmacy will have your medicine delivered to you within one to three working days. Read more about this process here.

Instruction costs (includes consult & service fee)
Service – Instruction costs (includes consult & service fee)

Acne is a very common condition that affects 11-30 years olds, it usually starts at some point during puberty but can appear later in life. It mainly occurs on the face, neck, back and chest and can be a case of just a few spots or a far more serious condition. There are actually six different types of acne spots: blackheads, whiteheads, papules, pustule, nodules and cysts – the larger, more painful types of spots can lead to permanent scarring. Like any skin condition, acne can also affect mental health and self-confidence, often acne sufferers may try to avoid social situations for fear of other people’s reaction to their skin. The good news is that there are a wide range of acne treatments available, from over-the-counter remedies, cleansing solutions etc. through to stronger treatments like specific prescription creams and gels or oral antibiotics. If the over-the-counter remedies aren’t working for you, you might like to try a stronger prescription solution. 

What is Treclin? 

Treclin is a medicated gel that contains two different active ingredients, Clindamycin and Tretinoin. 

It contains 1% Clindamycin and 0.025% Tretinoin. 

Tretinoin helps skin to regenerate normally, shedding dead cells so that they do not block the hair follicles. This prevents the build-up of sebum on the skin which is one of the causes of acne. 

Clindamycin is an antibiotic so it works to inhibit the bacteria that causes inflammation and acne. Bacteria grows unless it is contained, antibiotics limit the growth of bacteria by breaking down the protein walls surrounding it. 

These two active ingredients work more effectively when combined than they do separately. 

When is Treclin used? 

Treclin is used to treat mild to moderate acne in adults and children over the age of 12 when there is a presence of comedones, pustules and papules which are different kinds of acne spots: 

  • Comedones are raised skin coloured bumps on the skin and can be open (then they are called blackheads); 
  • Papules are also raised bumps on the skin but these are usually red and inflamed and they frequently turn into pustules; 
  • Pustules are inflamed skin pores clogged with pus, sebum or skin debris, also called pimples. 

Treclin can be used on the face, to help with all of the spots listed above: 

  • It has an anti-inflammatory effect which lessens irritation and soreness of the skin; 
  • It works to prevent acne at the cause by encouraging the skin to follow the correct process of regrowth and preventing pores from clogging. 
  • It works on the surface of the skin to restore skin tone and clear acne and prevent breakouts. 

How do you use Treclin? 

Always follow your doctor’s instructions when it comes to using any medicated product and check with them if you are unsure about anything at all. 

Treclin is used on the face: 

  • Start by washing your hands and face with mild soap and water and then pat dry; 
  • Break the seal of the tube if using Treclin for the first time; 
  • Squeeze a pea-sized amount of gel onto your fingertip; 
  • Gently dab the gel onto your cheeks, nose and forehead and then gradually spread it around your face with your fingertips aiming for an even layer of gel; 
  • Replace the cap on the cream and store safely before washing your hands; 
  • Take care to avoid getting the gel in your eyes, nose or mouth – if this does happen rinse immediately with plenty of water; 
  • Avoid applying to sensitive areas of the skin; 
  • Do not apply to skin where there is eczema present; 
  • When using Treclin avoid too much sunlight or artificial light such as a sun lamp and always use suncream of at least SPF 30; 

What dosages are there? 

Always follow your doctor’s advice when it comes to how much of any medication you should take or use, as they will know more about your personal medical history than anyone else.

Treclin contains an antibiotic so it is important you finish the course of treatment and do not stop just because you are noticing a difference. 

Treclin comes in a tube containing 30g of cream. It is usually used as follows: 

  • Treclin should be used just once a day at bedtime; 
  • A pea-sized amount of gel is sufficient to cover the face; 
  • Do not be tempted to use more gel than you need as it won’t make your acne clear-up any faster but may cause irritation and additional issues such as redness and flaking of the skin; 
  • You will need to use Treclin for as long as you are instructed to by your doctor; 
  • This may be up to 12 weeks; 
  • You should not use the cream for longer than 12 consecutive weeks; 
  • Do not be tempted to cut your treatment short, even if your skin appears to have cleared up, as the underlying bacteria will still be trying to grow, so stopping your treatment too soon may made lead to a worse flare up at a later stage which is then more resistant to antibiotics; 
  • If you forget to apply your gel at bedtime then simply miss that application and apply your usual dose at bedtime the next day – try to remember every day as missing a dose means giving the bacteria chance to grow – it can help to set an alarm to remind you to put on your cream before bed. 

What are the side effects of Treclin? 

As with all medicines, Treclin comes with a warning of some side effects, although not everyone who uses Treclin will experience them. If you experience side effects and are worried about anything then contact a medical professional for help. 

The most common side effects with Treclin are, in fact, not that common at all, they are classed as uncommon meaning they affect up to 1 in 100 people, these uncommon side effects include: 

  • Increased sebum production; 
  • Worsening of ance; 
  • Scaling skin; 
  • Skin redness; 
  • Itching; 
  • Rashes; 
  • Sunburn; 
  • Dry skin; 
  • Skin reactions where you have applied the cream: 
    • Inflamed skin; 
    • Dryness; 
    • Redness; 
    • Burning sensation. 

Rare side effects that may affect up to 1 in 1,000 people include: 

  • Eye irritation; 
  • Hypersensitivity; 
  • Headaches; 
  • Pain; 
  • Feeling hot; 
  • Gastroenteritis; 
  • Inflamed skin; 
  • Cold sores; 
  • Skin irritation; 
  • Burning sensation on the skin; 
  • Irritation where you apply the gel; 
  • Loss of pigmentation; 
  • Underactive thyroid gland – look out for: 
    • Feeling weak; 
    • Feeling tired; 
    • Dry hair; 
    • Rough skin; 
    • Hair loss; 
    • Weight gain; 
    • Sensitivity to cold. 

When shouldn’t you use Treclin? 

No medication is suitable for everyone that suffers from a certain condition. It will depend on the severity of your condition and the medical history of both you and your family as to whether certain treatments can be used. Do not use Treclin to treat your acne if any of the following apply: 

  • You are allergic to clindamycin, tretinoin or any of the other ingredients listed on the packet; 
  • You are allergic to lincomycin; 
  • You are pregnant or planning a pregnancy; 
  • You have a history of colitis when taking antibiotics with long-lasting diarrhoea or stomach cramps; 
  • You have a chronic inflammatory bowel disease like Crohn’s disease or ulcerative colitis; 
  • You are experiencing severe eczema with inflamed, red, scaly, dry skin; 
  • You or a member of your family has ever had skin cancer; 
  • You have any kind of acute inflammatory skin condition, for example, folliculitis; 
  • You have rosacea – a skin condition that causes redness, pimples and peeling, especially on the face; 
  • You have a certain type of acne called acne vulgaris which manifests with pustular, deep cystic nodular acne lesions. 

Does Treclin interact with other medications? 

Always tell your doctor about any medicines you are taking or have recently taken before you start a new course of treatment. Some medicines can interact with each other, making them less effective or causing other problems. This includes herbal remedies, vitamins and supplements. 

With Treclin you should take care with the following medicines: 

  • Any treatments that contain sulphur, salicylic acid, benzoyl peroxide, rescinol or any clinical abrasives – You will need to wait until you are no longer experiencing the effects of these treatments before you start using Treclin; 
  • Medicated soaps and cleansers or scrubbing solutions that have a drying effect; 
  • Antibiotics; 
  • Corticosteroids; 
  • Muscle relaxants or neuromuscular blocking medicines; 
  • Products containing metronidazole, aminoglycosides or erythromycin; 
  • Medicines to thin the blood like Warfarin 

Where can you buy Treclin? 

You can buy Treclin from any reputable pharmacy, you need a dedicated pharmacy and not just a shop which sells some medicines as a pharmacist is needed to dispense this medicated cream. 

Can I get Treclin without a prescription? 

No, you cannot get Treclin without a prescription, you will need a consultation with a doctor in order to be prescribed Treclin and be able to buy it. This is because it contains an antibiotic and antibiotics are strictly controlled as they only work for specific bacterial infections. This means a doctor must confirm you have a bacterial infection and monitor your treatment, especially the duration of the treatment so you use it for the smallest time possible to cure your acne.  

Treclin will usually only be prescribed if you have already tried over-the-counter acne remedies without success. 


British Skin Foundation, n.d. Acne. British Skin Foundation. Retrieved 28 April 2020 from <

Chaplin, S., 2020. Treclin: Tretinoin/Clindamycin Combination For Acne. Retrieved 28 April 2020 from < n.d. Treclin | MIMS Online. Retrieved 28 April 2020 from <

Mylan Products Ltd, 2019. Retrieved 28 April 2020 from <

Assessed by:

Dr Imran Malik, General practitioner
Registration number: GMC: 4741365

Dr Imran Malik studied undergraduate medicine at King's College University in Central London and clinical studies at the prestigious King's College Hospital. He graduated with a MBBS degree in 2000 and went on to gain postgraduate memberships with the Royal Society of Medicine and also General Practice in 2006.