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Nerisone cream and ointment come with the active ingredient diflucortolone valerate within them. This a medication that belongs to the topical corticosteroid family. There are a wide range of topical corticosteroids that can be applied to the skin, and Nerisone is a highly potent option for people who have inflammatory skin conditions like dermatitis and eczema. More information

A doctor will review your order and write you a prescription, if appropriate. This prescription is then forwarded to a pharmacy. The pharmacy will have your medicine delivered to you within one to three working days. Read more about this process here.

Nerisone is an ointment and cream that contains the active ingredient diflucortolone. This potent topical corticosteroid is a type of medication that can be used to reduce the inflammation of the skin and keep issues like itching and discomfort to a minimum. 

What is Nerisone? 

Nerisone cream and ointment come with the active ingredient diflucortolone valerate within them. This a medication that belongs to the topical corticosteroid family. There are a wide range of topical corticosteroids that can be applied to the skin, and Nerisone is a highly potent option for people who have inflammatory skin conditions like dermatitis and eczema.  

Nerisone is available in the form of an ointment, oily cream, or cream, depending on the nature of your condition and the issue to be treated. You will be prescribed Nerisone based on your condition. For instance, the cream is more suitable for weeping areas of skin as it isn’t as greasy as the other formulations. Additionally, Nerisone allows secretions from the skin to drain more completely. Nerisone is better suited for moist and hairy patches of skin.  

The Nerisone oily cream is greasier and intended for skin that is not weeping or overly dry. Alternatively, the ointment is the greasiest option and it is intended for people with very dry skin. This particular version of Nerisone allows for an extra layer of oil to be placed on the surface of the skin. This prevents water from evaporating and reduces scaliness and dryness as a result. 

When is Nerisone used? 

Nerisone is a potent form of topical corticosteroids. These substances are used alongside moisturizers and other substances to treat the conditions caused by inflammatory issues in the skin. If you suffer from dermatitis or eczema, then you may need to use Nerisone. This substance is used when patches of dermatitis and eczema flare up. Nerisone is used to relieve the symptoms of a flare-up by reducing inflammation, redness and itching. This substance will not cure your skin condition, but it helps to relieve the symptoms significantly.  

Nerisone is a form of corticosteroid used for the reduction of the inflammation of skin that may happen as the result of irritation of the skin or allergy. In the human body, inflammation can happen at any time, and it is caused by the release of numerous substances that are crucial to the immune system. Substances in your body cause the blood vessels to widen, which means that the irritated area becomes itchy, swollen and painful. Nerisone can work by acting inside of the skin cells to decrease the activity of inflammatory substances.  

How do you use Nerisone? 

Nerisone is a topical steroid, which means that it needs to be applied directly to the skin. Before you begin using this medication, it is important to read the printed information leaflet within the packet. This leaflet will provide you with useful information about topical steroids, and it could also give you some insights on the side effects that you might experience when using Nerisone. Before you begin using Nerisone, wash your hands, and the area that you wish to treat carefully.  

Apply a small amount of Nerisone to the area that you want to treat, careful not to use too much, and gently rub it into the skin. Do not rub the skin too much. Do not cover the skin with a bandage unless you have been advised to do so. The amount of Nerisone that you need to apply is often measured according to your fingertip. A single fingertip is enough to cover a very large area. You will not need to use much Nerisone. Using more of this medication will increase your chances of side effects, but it will not reduce your symptoms any faster.  

Your consultant can tell you how and when to apply your dose of Nerisone. Make sure that you do not apply this substance more than twice a day. Once a day should be more than enough. If you are using multiple corticosteroids like Nerisone at once, you will need directions from your consultant. Make sure that you know how much time you need to leave between using each one. If you’re not sure, ask your doctor for advice.  

After you have applied Nerisone, make sure that you wash your hands carefully. If you’re using Nerisone for psoriasis, make sure that you follow the instructions provided by your doctor carefully. You should not be using this medication on large areas of skin or for particularly long periods of time, as this can increase your risks of side effects.  

Nerisone is not suitable for children unless your expert has told you otherwise. Children are often more susceptible to the side effects that are common with strong topical steroids. The main concern for many children is that it is possible for corticosteroids to have an effect on their growth, and this needs to be monitored. If your child has been prescribed Nerisone, then you will need to follow the instructions given carefully.  

What dosages are there? 

The dosage provided for your condition when you are given Nerisone will depend on your response to previous treatments and the ailment that you need to address. There are two strengths available for Nerisone in most circumstances. Preparations that include 0.1% diflucortolone are the more potent options. There’s also a higher-strength solution with 0.3% of the active ingredient. This is a very potent topical steroid. You will potentially get a higher dose of Nerisone if your condition hasn’t responded to the lower-strength cream. 

Your doctor may start you on a low dose of Nerisone to reduce your risk of side effects, then gradually increase your dosage depending on your needs. When your symptoms begin to approve when using Nerisone, your dose will be reduced again. Specialist experts may sometimes prescribe very short courses of Nerisone for the treatment of various conditions. Additionally, it is not a good idea to use this substance in children unless it has been advised by a specialist.  

Nerisone is available in a number of different forms. The chances are that you will be prescribed the cream version of this medication if you have weeping or moist patches of skin to treat.  

What are the side effects of Nerisone? 

Most people will respond well to Nerisone without any significant side effects. However, it is possible that you may encounter problems when taking this medication. It is important to discuss your medical history with your consultant to see whether your risk of side effects is higher than it should be. Remember that just because a side effect has been listed here, doesn’t mean that you will experience it. The most common side effects of Nerisone will disappear over time as your body gets used to the medication, these include: 

  • Redness and irritation at the site of the applied cream; 
  • Contact dermatitis; 
  • Thinning in the skin; 
  • Stretch marks; 
  • Changes in skin pigmentation; 
  • Grouping of fine blood vessels beneath the skin;

If you notice any side effects after taking Nerisone that are not listed here or in your patient leaflet, you should contact a doctor or pharmacist for more advice and stop using the medication until you find out more. Remember that it is possible to have an allergic reaction when taking Nerisone, although your risk of an allergic reaction is low. 

If after using Nerisone, you notice a rash or swelling at the site of the application, or you begin to suffer from sever dizziness and trouble breathing, then you should contact a healthcare professional as quickly as possible to get more advice.  

When shouldn't you use Nerisone? 

Nerisone will not be suitable for all cases. It is important to speak to your consultant about your condition and your medical history to ensure that this treatment is right for you. For instance, you should not usually use Nerisone with psoriasis, although the drug can sometimes be prescribed by a specialist. The same is true for use with children. 

In general, Nerisone should not be used when people are suffering from a chronic inflammatory disorder of the skin or acne. Additionally, you should avoid using this substance when you have viral skin infections like cold sores and shingles, or bacterial skin infections like impetigo.  

You will not be suitable to use Nerisone if you have fungal skin infections like thrush, nappy rash, itching around the genitals and back passage, ulcerated areas of skin, or a rash around the mouth. Make sure that you do not use Nerisone if you are allergic to any of the ingredients included. Tell your consultant if you are allergic to anything. Remember that this medication can include inactive ingredients that might also contribute to allergic reactions.  

Does Nerisone interact with any other medications? 

Nerisone isn’t currently known to affect other medications in a dangerous manner. However, it is worth telling your consultant about all of the medications that you are taking just in case. This includes making sure that they know about your prescription medications, over the counter drugs, and even your supplements or herbal medications.  

If you are planning on using other medications at the same site that you’re using Nerisone, make sure that you know how long you need to leave between each medicine being applied. This will allow the product extra time to be absorbed properly into the skin. Additionally, if you’re applying moisturizers when also using this medication, you will need to do that at a different time of the day. Applying moisturizers can dilute Nerisone and make it less effective.  

Where can you buy Nerisone? 

Nerisone is available to purchase online. You should see a doctor face to face initially to advise you how best to manage your condition. 

Complete a consultation with an online expert to have your prescription sent for you to a local pharmacy.  

Can you get Paracetamol without a prescription?  

Nerisone is not available for you without a prescription. Your consultant can have a prescription delivered to a pharmacy for you within 3 days.  

Sources online, 2019, “NERISONE FORTE OILY CREAM”, [Accessed 3rd of December 2019], Available on: 

Mims, online, 2019, “Nerisone Forte” [Accessed 3rd of December 2019], Available on:

Patient info, 2019,  “Diflucortolone for severe inflammatory skin conditions” [Accessed 3rd of December 2019], Available on: 


Assessed by:

Dr Imran Malik, General practitioner
Registration number: GMC: 4741365

Dr Imran Malik studied undergraduate medicine at King's College University in Central London and clinical studies at the prestigious King's College Hospital. He graduated with a MBBS degree in 2000 and went on to gain postgraduate memberships with the Royal Society of Medicine and also General Practice in 2006.