Sandrena gel

Sandrena Gel is a female Hormone Replacement Therapy or HRT solution that contains the hormone oestrogen. Sandrena is used to relieve the symptoms of menopause, including issues like hot flushes and general discomfort. Sandrena will only be prescribed to patients who feel as though their menopause symptoms are hindering their quality of life.

What is Sandrena?

Sandrena gel is an HRT (Hormone replacement therapy) that contains a synthesised version of the female hormone oestrogen. As women get older and their ovaries begin to produce less oestrogen, the declining levels can lead to symptoms like night sweats, hot flushes, irregular periods, vaginal dryness, and mood swings. Sandrena gel can be given as a supplement to women suffering from oestrogen to replace the levels that are dropping in the body and keep symptoms to a minimum. HRT is typically only required for a short period, and its use must be reviewed regularly with a doctor. Sandrena is a form of oestrogen-only HRT which is applied directly to the skin and absorbed into the bloodstream.

When is Sandrena used?

Because Sandrena gel only contains oestrogen, it’s often suitable for women who have had a hysterectomy. If you have not had a hysterectomy, then your doctor will usually prescribe a progesterone medication to take alongside this substance.

This is because Sandrena and oestrogen-containing drugs will increase the thickness of the womb lining. This can lead to cancerous growths if not opposed by progesterone. Progesterone is intended to reduce the impact of the Sandrena on the womb lining and therefore lower the risk of cancer. However, using Sangrena gel and progesterone does not mean that the risks are completely eliminated. When the womb has already been surgically removed through a hysterectomy, progesterone is not necessary as part of treatment. There is no scientific evidence on Sandrena Gel weight loss, although studies do show that applying oestrogen as a gel does not lead to weight gain.

How do you use Sandrena?

When taking any Hormone Replacement Therapy treatment, it’s important to follow the instructions provided with your medication. Sandrena gel sachets come ready to use, and there are different strengths of Sandrena gel sachets available depending on the nature of your symptoms and your medical background. If you’re unsure about the instructions on how to use Sandrena, speak to your GP or pharmacist.

Usually, Sandrena gel will need to be applied every day to a clean and dry area of the skin on the thigh or lower stomach. Alternate using Sandrena gel on the right and left sides of your body each day. Generally, it’s recommended to spread Sandrena gel over an area about double the size of your hand. Once Sandrena gel has been applied, leave it to dry for at least five minutes before applying any clothes. Do not apply any powders or lotions to the area for at least an hour after application. Do not apply Sandrena gel to the vaginal area, face, or breasts. After applying Sandrena, wash your hands and avoid contact with the eyes. Do not let someone else apply Sandrena gel for you and avoid contact with other people (particularly men) after applying. You should also attempt to apply Sandrena at about the same time each day.

What dosages are available?

Your doctor will prescribe the correct dose of Sandrena gel sachets based on an evaluation of your symptoms. The usual dose is 1 to 5 mg of Sandrena gel a day.

If you forget to use Sandrena gel at your usual time and it’s less than 12 hours late, you can apply the missed dose as soon as possible. If you’re more than 12 hours late applying your dose of Sandrena gel, carry on with the next dose as normal. Do not apply double the dose of Sandrena to make up for the missed dose.

What are the side effects of Sandrena?

Most people will not experience any serious side effects as a result of using Sandrena gel and progesterone. However, like any medicine, you may notice some unwanted outcomes. For instance, it’s common to experience issues like:

  • Skin irritation at the site of the application;
  • Fluid retention and swelling;
  • Vaginal thrush;
  • Increase in uterine fibroids;
  • Nausea and vomiting;
  • Bloating and flatulence;
  • Mood changes like anxiety and depression;
  • Dizziness and fatigue;
  • Changes in sex drive;
  • Migraine or headache;
  • Breast pain or tenderness;
  • Menstrual bleeding or spotting;
  • Weight changes.

You may also notice some slightly less common side effects, including skin reactions like rashes and itching, or irregular brown patches on the skin. Some people notice a rise in blood pressure. Some more serious side effects include disturbances in liver functioning, which may lead to yellowing of the skin or eyes. Additionally, when using Sandrena there’s a possibility for inflammation of the pancreas, blood clots, and an increased risk of gallbladder disease. Some people using Sandrena gel may experience a steepening of the curvature in their corneas, which makes it harder for them to wear contact lenses comfortably.

Make sure that you speak to a doctor or care provider immediately if you notice any signs of a potential allergic reaction to Sandrena. This might include sudden rashes or itching, swelling of the mouth, tongue or throat, or trouble breathing. This is not a complete list of side effects that may occur as a result of Sandrena. If you think you are experiencing side effects because of Sandrena gel, stop taking the substance immediately and contact your pharmacist or doctor.

When shouldn't you use Sandrena?

There are circumstances where your doctor may recommend that you don’t use Sandrena gel. For instance, if you have a risk of developing cancer that could be stimulated by oestrogen – such as breast cancer, then Sandrena might not be right for you. If you have a history of benign breast lumps or fibroids in your womb, then your doctor may also recommend that you avoid taking Sandrena.

Other women that may not be able to take Sandrena include:

  • Women who are obese or very overweight;
  • Women with severe varicose veins;
  • Women with a history of endometriosis;
  • Women with severe varicose veins;
  • Women taking medications to prevent blood clots;
  • Women who have high blood pressure;
  • Women with diabetes;
  • Women with raised levels of fats like cholesterol in their blood;
  • Women with long-term conditions like SLE;
  • Women with a family history of blood clots;
  • Women who suffer from severe headaches or migraines;
  • Women who suffer from inherited blood disorders;
  • Women who have unexplained brown matches appearing on their skin.

Your doctor will not prescribe Sandrena gel sachets if you have a suspected or known history of breast cancer. Women with an untreated overgrowth in the lining of their womb, vaginal bleeding when the cause is not known, or women with blood disorders that could increase their risk of blood clotting will also not be suitable for Sandrena. Sandrena gel is not suitable for women who are pregnant or breastfeeding. Additionally, your doctor will not prescribe you Sandrena if you are allergic to any of the ingredients within it. It’s important to speak to your doctor carefully about your medical history so that they know whether it’s a good idea to prescribe Sandrena gel to you.

Does Sandrena interact with any other medications?

Your doctor will need to assess your medical history and background carefully before prescribing Sandrena gel. To make sure that you are safe to take Sandrena, ensure that you tell your doctor if you’re taking any other medication, including prescription drugs and over the counter medicines. You should also tell your doctor if you’re taking any herbal remedies or supplements.

Various medications can potentially reduce the effects of this medicine, including:

  • Bosentan;
  • Aprepitant;
  • Efavirenz;
  • Modafinil;
  • Aprepitant;
  • Bosentan;
  • Barbiturates;
  • Carbamazepine;
  • Cobicistat;
  • Phenytoin;
  • Oxcarbazepine;
  • Ritonavir;
  • Rifampicin;
  • Phenobarbital;
  • Telaprevir;
  • St JOHN’S Wort;
  • Primidone.

This is not a complete list of the drugs that may interact negatively with Sandrena gel. Some women with diabetes will need to make adjustments to their antidiabetic tablets and insulin when using this medicine. You should monitor your blood glucose levels carefully when taking Sandrena gel and speak to your doctor if you feel as though your blood sugar is more difficult to control when you’re using this medicine.

Sandrena can also lead to issues when taking medication to help with lowering high blood pressure. Your blood pressure will need to be checked more often when you are taking or using hormone replacement therapies, including Sandrena gel. Additionally, Samdrena gel can also oppose the fluid-reducing symptoms of diuretic medicines. If you are concerned that any of the medicines that you are currently taking might not interact well with Sandrena, speak to your doctor or pharmacist before continuing with this medication. Your doctor will assess all the risks in using Sandrena gel for you before offering a prescription.

Where can you buy Sandrena?

Sandrena gel is available to purchase either online or offline from a registered pharmacy. However, you will need a prescription to take this medication. This is because there are different types of Sandrena available and different dosages that your doctor will need to consider.

Before you seek out a place to buy Sandrena gel, make sure that you have spoken to your doctor to find out whether Sandrena gel is the right option for you.

Can you get Sandrena without a prescription?

Like all hormone replacement therapy treatments, Sandrena gel can only be obtained with a prescription. Your doctor will need to conduct a full medical assessment to find out whether Sandrena is appropriate in your condition, and whether there is a specific dose that will be best suited to you. Do not try to purchase Sandrena gel from a pharmacy without a prescription and do not trust any company that offers you Sandrena gel without approval from your doctor.


Aspen Pharmacare Australia Pty Ltd, Australia, October 2017, Sandrena-Gel, online, [Accessed 19th of June 2019] Available on, Updated December 2019, Sandrena Side Effects, online, [Accessed 19th of June 2019] Available on

Orion Pharma (UK) Ltd, Sandrena 0.5 mg gel, online, [Accessed 19th of June 2019] Available on

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